Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System by Yung-Yu Chang (1724704)

“…Conformational flexibility in dipyridylethene <b>9</b> is clearly shown by its complexation with BH₃ to form helical atropisomers (<i>P,P</i>/<i>M,M</i>)-<b>10</b>. The p<i>K</i>_a values of the conjugate acids of <b>1A</b> and <b>9</b> in acetonitrile were determined to be 4.65 and 5.07, respectively, which are much smaller compared to that of pyridine <b>14a</b> (p<i>K</i>_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of <b>1A</b> and <b>9</b> are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyheterocycles.…”

Predictors of Visceral Leishmaniasis Relapse in HIV-Infected Patients: A Systematic Review by Gláucia F. Cota (218288)

“…Two studies found that baseline CD4+ T cell count above 100 cells/mL was associated with a decreased relapse rate. The observation of an increase in CD4+ T cells at patient follow-up was associated with protection from relapse in 5 of 7 studies. …”

Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System by Yung-Yu Chang (1724704)

“…Conformational flexibility in dipyridylethene <b>9</b> is clearly shown by its complexation with BH₃ to form helical atropisomers (<i>P,P</i>/<i>M,M</i>)-<b>10</b>. The p<i>K</i>_a values of the conjugate acids of <b>1A</b> and <b>9</b> in acetonitrile were determined to be 4.65 and 5.07, respectively, which are much smaller compared to that of pyridine <b>14a</b> (p<i>K</i>_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of <b>1A</b> and <b>9</b> are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyheterocycles.…”

Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System by Yung-Yu Chang (1724704)

“…Conformational flexibility in dipyridylethene <b>9</b> is clearly shown by its complexation with BH₃ to form helical atropisomers (<i>P,P</i>/<i>M,M</i>)-<b>10</b>. The p<i>K</i>_a values of the conjugate acids of <b>1A</b> and <b>9</b> in acetonitrile were determined to be 4.65 and 5.07, respectively, which are much smaller compared to that of pyridine <b>14a</b> (p<i>K</i>_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of <b>1A</b> and <b>9</b> are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyheterocycles.…”

Protein-protein docking for Parkin and a charged E2∼Ub complex. by Thomas R. Caulfield (655752)

“…The docking in the same position is shown and rotated 180° to reveal the other side. Residues of the Ubch5a-Ub complex are indicated by color (dark green and brown, respectively). …”

Cerebral Venous Sinus Thrombosis - Diagnostic Strategies and Prognostic Models: A Review by Penka A. Atanassova (7944506)

“…Patients with CVST commonly present with headache, although some develop a focal neurological deficit, decreased level of consciousness, seizures, or intracranial hypertension without focal neurological signs. …”

Factors associated with changing indications for adenotonsillectomy: A population-based longitudinal study by Jeng-Wen Chen (5310389)

“…Longitudinal data demonstrated an increasing trend in the pediatric AT rates from 1997 (4.3/100,000) to 2010 (5.7/100,000) (<i>p</i> = 0.029). In the adult subgroup, a decreasing prevalence of infectious indications (<i>p</i> = 0.014) coincided with an increasing neoplastic indications (<i>p</i> = 0.001). …”

Deformative Transition of the Menschutkin Reaction and Helical Atropisomers in a Congested Polyheterocyclic System by Yung-Yu Chang (1724704)

“…Conformational flexibility in dipyridylethene <b>9</b> is clearly shown by its complexation with BH₃ to form helical atropisomers (<i>P,P</i>/<i>M,M</i>)-<b>10</b>. The p<i>K</i>_a values of the conjugate acids of <b>1A</b> and <b>9</b> in acetonitrile were determined to be 4.65 and 5.07, respectively, which are much smaller compared to that of pyridine <b>14a</b> (p<i>K</i>_a = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of <b>1A</b> and <b>9</b> are markedly decreased by the severe steric hindrance of the flanking phenyl rings in the polyheterocycles.…”

The association between previous and future severe exacerbations of chronic obstructive pulmonary disease: Updating the literature using robust statistical methodology by Mohsen Sadatsafavi (63962)

“…<div><p>Background</p><p>There is minimal evidence on the extent to which the occurrence of a severe acute exacerbation of COPD that results in hospitalization affects the subsequent disease course. …”

Influence of natural gas composition on adsorption in calcite Nanopores: A DFT study by Elbashier E.

“…The nanopores absorbed up to 28 and 24 molecules of CH4 and CO2, respectively, and the adsorption energy decreased to −0.0062 and −0.0075 eV/Å2 for each. Although the nanopore was filled spatially by the molecules, its surface still has an affinity to absorb more gas molecules energetically. …”
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Pyrvinium inhibits WNT signaling in a CK1α dependent manner. by Bin Li (39349)

“…<p><b>A</b>. The expression of the WNT target gene: <i>AXIN2</i> was determined from NIH 3T3 cells expressing control or <i>CK1α</i>-specific shRNAs. …”

Volatility persistence and inventory effect in grain futures markets: evidence from a recursive model by Rodrigo Lanna Franco da Silveira (4648684)

Genetic variance of a trait under stabilizing selection with multi-population demography. by Aaron P Ragsdale (20968248)

“…In Deme 2, <i>V_G</i> decreases due to their population size reduction. …”

Association between breastfeeding and eczema during childhood and adolescence: A cohort study by Jingying Wang (4458820)

Expression pattern of a <i>puc</i> reporter line in the central brain. by David Kapfhamer (295513)

“…<p><b><i>A</i></b>, Rescue of decreased <i>puc¹/+</i> ethanol-induced locomotor stimulation in the <i>NP1311</i> expression pattern. …”

Supplementary Material for: Trends in Literature on Cerebral Bypass Surgery: A Systematic Review by Grüter B.E. (11166240)

“…<b><i>Methods:</i></b> A systematic literature research was conducted using PubMed, Web of Science, EMBASE, and SCOPUS databases. …”

Epidemiology of harmful use of alcohol in Nigeria: a systematic review and meta-analysis by Davies Adeloye (589375)

“…However, actual age-adjusted prevalence of harmful use of alcohol in Nigeria decreased from 38.5% to 32.6% over the twenty-year period.…”

Down-regulation in antimicrobial and absorption expression programs. by Noam Cohen (319186)

“…Black dashed lines represent mean values; white dots represent median values of 5 repeats of at least 3 individual FAE from 2 mice. …”

Ligand-dependent stability of a 240 kDa protein can be probed by FASTpp. by David P. Minde (304427)

“…A gradual decrease in the band intensity at higher temperatures indicates unfolding. …”

Effect of using Cement Kiln Dust as a nano-material on the strength of cement mortars by Alnahhal, Wael

“…The CKD was milled up to 4 hours in a planetary ball mill. In addition to the control cement mortar mixture with 0% CKD, a total of 28 concrete mortar mixtures were prepared with four different replacement percentages of nano-CKD (5, 10, 15, and 20 %), and seven different milling times (1, 1.5, 2, 2.5, 3, 3.5, and 4 hours). …”
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