Image_1_Liver-Specific Knockdown of Class IIa HDACs Has Limited Efficacy on Glucose Metabolism but Entails Severe Organ Side Effects in Mice.TIF by Nicole Ziegler (6893297)

“…For that, siRNAs selectively targeting HDAC4, 5 and 7 were selected and used to achieve a combinatorial knockdown of these three class IIa HDAC isoforms. …”

Macro-regions of Brazil. by Arnauld Kaufman (12731976)

“…Our results demonstrated a significant increase in the AAPC in Brazil’s less than 1-year-old age group and a decrease in children from 5 to 19 years old. …”

Table_1_Liver-Specific Knockdown of Class IIa HDACs Has Limited Efficacy on Glucose Metabolism but Entails Severe Organ Side Effects in Mice.docx by Nicole Ziegler (6893297)

“…For that, siRNAs selectively targeting HDAC4, 5 and 7 were selected and used to achieve a combinatorial knockdown of these three class IIa HDAC isoforms. …”

Dissecting the Epstein–Barr virus entry pathway into astrocytes: unfolding the involvement of endosomal trafficking by Annu Rani (11223925)

“…</p> <p>EBV internalization decreased upon depletion of the lipid rafts.</p> <p>The dynamin protein plays a crucial role in EBV entry into astrocytes, and its depletion indicates a decrease in EBV entry.…”

Image_2_Liver-Specific Knockdown of Class IIa HDACs Has Limited Efficacy on Glucose Metabolism but Entails Severe Organ Side Effects in Mice.TIF by Nicole Ziegler (6893297)

“…For that, siRNAs selectively targeting HDAC4, 5 and 7 were selected and used to achieve a combinatorial knockdown of these three class IIa HDAC isoforms. …”

ICD-10 version 2015. by Arnauld Kaufman (12731976)

“…Our results demonstrated a significant increase in the AAPC in Brazil’s less than 1-year-old age group and a decrease in children from 5 to 19 years old. …”

CKDMR in Brazil. by Arnauld Kaufman (12731976)

“…Our results demonstrated a significant increase in the AAPC in Brazil’s less than 1-year-old age group and a decrease in children from 5 to 19 years old. …”

Image_1_Pharmacological Preconditioning Using Diazoxide Regulates Store-Operated Ca2 + Channels in Adult Rat Cardiomyocytes.JPEG by Raúl Sampieri (8297634)

“…Previously, we reported that pharmacological preconditioning (PPC) leads to a decrease in the amplitude of L-type calcium channel current in the heart. …”

Data_Sheet_1_Impact of Alcohol Outlet Density on Reported Cases of Child Maltreatment in Japan: Fixed Effects Analysis.docx by Yuna Koyama (7462883)

“…Also, a negative association was observed between a change in the incidence of total child maltreatment by father and a change in alcohol outlet density (coefficient = −3.03, 95% confidence interval: −5.78, −0.28).…”

Sequence motifs function “out of context”. by Ido Yofe (589603)

“…C) Reporter YFP expression is decreased upon exchange of an enhancer to a silencer motif in two independent intron strains. …”

The transient K⁺ currents displayed sensitivity towards holding potentials, and the magnitude changes during development. by Snezana Levic (336804)

“…(<b>C</b>) Mean difference current density at +0 mV at apical and basal regions of the basilar papilla (pA/pF) at E8, E10, E12, E16, and P2. …”

DataSheet_1_Regulation of SPDEF expression by DNA methylation in advanced prostate cancer.pdf by Mousa Vatanmakanian (15171089)

“…</p>Results<p>In this report, we observed that: a) there is a gradual decrease in SPDEF expression with a concomitant increase in methylated CpG sites within the SPDEF gene during prostate cancer progression from lower to higher Gleason grade; b) Expression of DNMT’s (DNMT1, 3a and 3b) is increased during prostate cancer progression, and there is an inverse correlation between SPDEF and DNMT expression; c) SPDEF levels are decreased in RC77/T, a line of PCa cells from African American origin similar to PC3 and DU145 cells (CRPC cells), as compared to LNCaP cells , a line of androgen dependent cells,; d) the 5′ CpG island of SPDEF gene are hypermethylated in SPDEF-negative CRPC ( PC3, DU145 and RC77/T) cell lines but the same regions are hypomethylated in SPDEF-positive castrate sensitive (LNCaP) cell line ; (e) expression of SPDEF in PCa cells lacking SPDEF decreases cell migration and invasion, but has no significant effect on cell proliferation, and; (f) treatment with the demethylating agent, 5-aza-2′-deoxycytidine, or silencing of the DNMT’s by siRNA, partially restores SPDEF expression in SPDEF-negative PCa cell lines, and decreases cell migration and invasion.…”

DataSheet_1_Optimizing linear energy transfer distribution in intensity-modulated proton therapy using the alternating direction method of multipliers.pdf by Qingkun Fan (17379391)

“…</p>Results<p>The results demonstrate the superiority of ADMM-LET over ICR-LET in terms of LET distribution while achieving a comparable dose distribution. More specifically, for the brain case, the maximum LET (unit: keV/µm) at the optic nerve decreased from 5.45 (ICR-LET) to 1.97 (ADMM-LET). …”

BPLF1 promotes the accumulation of SUMOylated TOP2ccs and cell viability following Etoposide treatment. by Jinlin Li (2267896)

“…<p><b>(A)</b> HEK-rtTA-BPLF1 cells were cultured for 24 h in the presence or absence of 1.5 μg/ml Dox and then treated with 80 μM Etoposide for 30 min followed by detection of DNA trapped TOP2 by RADAR assay. …”

Table 1_Comparative effectiveness and safety of GATT with or without ABiC in patients with open-angle glaucoma.docx by Weijia Zhang (79845)

“…The number of medications was 0.6 ± 1.0 in Group 1 and 0.9 ± 1.3 in Group 2 (p = 0.334). At 24 months, the mean IOP was 15.3 ± 2.0 mmHg in Group 1 and 15.5 ± 2.4 mmHg in Group 2 (p = 0.676). …”

DataSheet1_Bayesian denoising algorithm dealing with colored, non-stationary noise in continuous glucose monitoring timeseries.docx by Nunzio Camerlingo (9394596)

“…</p><p>Results: On D_S1, BD allows reducing the root-mean-square-error (RMSE) from 8.10 [6.79–9.24] mg/dL to 6.28 [5.47–7.27] mg/dL (median [IQR]); on D_S2, RMSE decreases from 6.85 [5.50–8.72] mg/dL to 5.35 [4.48–6.49] mg/dL. …”

From melanoma and nevus to volatile signatures. by Tatjana Abaffy (35871)

“…A peak of 2,5 dimethyl benzenamine is shown eluting at 17.8 min. …”

<i>tph(RNAi)</i> animals lacking eye pigment are slower to orient to light. by Bramwell G. Lambrus (240053)

“…Triangles indicate the orientation of the light gradient, with the light source on the right. All points are color-coded for time, as shown by color bar legends. …”

Growth states before drug exposure affect survival. by Akihisa Seita (10063260)

“…In these experiments, MMC exposure started at 96 h (vertical broken line). Blue points represent the result of exposure to 50 nM MMC and green points represent the result of exposure to 200 nM MMC. …”

Differential Regulation of Extracellular Matrix and Soluble Fibulin-1 Levels by TGF-β₁ in Airway Smooth Muscle Cells by Ling Chen (25698)

“…Human ASM cells were seeded at a density of 1×10⁴ cells/cm², and stimulated with or without TGF-β₁ (10 ng/ml) for 72 hours before FBLN-1 deposition and soluble FBLN-1 were measured. …”