Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2‑Aminoquinoline Inhibitors by Maris A. Cinelli (1309419)

“…We previously developed a class of membrane-permeable 2-aminoquinoline inhibitors and later rearranged the scaffold to decrease off-target binding. …”

Antibody response elicited by SARS-CoV-2 vaccines. by Chris Davis (647632)

Prolonged transforming growth factor (TGF)-βtreatment induced a decrease in total Smad2 and/or Smad3 in many cell strains by Kimberly A Brown (26546)

Relative expression (fold-change) of immune genes in mitogen-stimulated splenic lymphocytes. by Chaiwat Monmai (6377270)

Heparin (GAG-hed) inhibits LCR activity of Human Papillomavirus type 18 by decreasing AP1 binding-5 by Rita Villanueva (65963)

“…Nuclear extracts obtained from HeLa cells were exposed to GAG-hed at indicated concentrations for 10 min before labelled probe addition (Panels B and D). On panel A and C, complex specificity is denoted by competition assays with a 100 fold excess of indicated oligonucleotide competitor. …”

Met decreases MYH1/2 and p21 expression and increases Myf5 and MyoD levels in myotubes. by Eleonora Maniscalco (14599854)

LOH unlinks 189R/R from a stop codon with masking effects on phenotype. by Pétra Vande Zande (17628246)

CXCL8 (2, 20, and 200 pg/ml) and CCL20 (5, 50, and 500 pg/ml) enhanced Ki-67 gene expression, but only 200 pg/ml of CXCL8 and 500 pg/ml of CCL20 enhanced early osteogenic marker ge... by Janak L. Pathak (759122)

HSP90 inhibition by RGRN-305 and 17-AAG decreased proinflammatory protein secretion. by Hakim Ben Abdallah (14578241)

ADGF-A expression during infection. by Adam Bajgar (730380)

TEM4 depletion decreases TEM4 mRNA and protein levels but no effect on spindle staining by the TEM4 antibody. by Diogjena Katerina Prifti (12988141)

Fold change of TIL subsets in paired TNBCs (N = 12 pts including 10 prim-met, and 2 met-met specimens) using log2 ratio of metastatic versus primary TNBC (n = 10, ●) or second recu... by Ting-Fang He (5210948)

Raw data used to generate the graphs shown in Figs 1B, 1E, 2B, 3B, 4B and 5A–5C of representative experiments from three independent biological repeats. by Timilehin Faboro (20175963)

Decrease of mitochondrial protein levels in human OPMD muscle biopsies. by Aymeric Chartier (713911)

Decrease in arginine and increase in citrulline after NEI-01 administration. by Jeremy P. H. Chow (8788208)

Telmisartan decreased NO production in LPS-stimulated BV2 and primary neonatal rat glial cells. by Nofar Torika (3169497)

Table_1_A glossy mutant in onion (Allium cepa L.) shows decreased expression of wax biosynthesis genes.xlsx by Tushar Kashinath Manape (16871172)

CK2α decreases CLK transcription factor activity. by Áron Szabó (450885)

Exogenous FGF4 decreases osteogenic differentiation of mESCs. by Sung-Ho Kook (445098)

SLAP depletion decreases ubiquitination and degradation of Flt3 receptor. by Julhash U. Kazi (291273)