Importance of SERCA2a on early isolated diastolic dysfunction induced by supravalvular aortic stenosis in rats by C.F.S.M.P. Silveira (6516089)

“…A wide spectrum of studies report a decrease in SERCA2a in heart failure, but none evaluate it's the role in early isolated diastolic dysfunction in supravalvular aortic stenosis (AoS). …”

The chronic effects of muscle-resistance training in arterial pressure of hypertensive older adults: a meta-analysis by Priscila dos Santos Bunn (5376581)

“…Results: The meta-analysis of five studies considering 96 hypertensive individuals who underwent RT and 104 hypertensive control subjects showed that the regular practice of RT from 12 to 16 weeks, three times a week, with three sets from 8 to 12 repetitions at an intensity of 60% to 80% of one-repetition maximum (1-RM), significantly reduced SBP by 7.26 mmHg (95%CI = -9.16 - 5.37) and DBP by 4.84 mmHg (95%CI = -5.89 - 3.79). …”

LYZL6, an acidic, bacteriolytic, human sperm-related protein, plays a role in fertilization by Peng Huang (105814)

“…Immunoneutralization of LYZL6 significantly decreased the numbers of human spermatozoa fused with zona-free hamster eggs in a dose-dependent manner <i>in vitro</i>. …”

Reduction of rotavirus as a cause of nosocomial diarrhoea in northern Stockholm after introducing the rotavirus vaccine by Selma Olsson-Åkefeldt (11500789)

“…Of these, 401 (85%) occurred in children with chronic medical conditions. In children <5 years the rates of nosocomial rotavirus gastroenteritis, with 95% confidence intervals, significantly decreased from 0.34 (0.25—0.45) per 100 admissions prevaccination to 0.09 (0.04—0.17) postvaccination and from 0,66 (0.48—0.88) to 0.16 (0.07—0.30) cases per 1000 hospital days. …”

Color retinography as a means of screening for diabetic retinopathy in the tertiary hospital of Unified Health System by Julia Quadri Bortoli (13289187)

“…A total of 114 (15.68%) patients were considered at high risk (those with severe non-proliferative NP and/or EM, proliferative DR or poor image) and were referred for comprehensive ophthalmic evaluation. …”

miR-34a may mediate neurite outgrowth by downregulating SIRT1 expression. by Márcia M. Aranha (211052)

“…The blue line corresponds to SIRT1 modulation, while the red line corresponds to the respective control. <b>A.</b> Representative immunoblot showing decreased SIRT1 expression after transfection with SIRT1 siRNA. …”

Supplementary Material for: Ketamine’s Effects on the Glutamatergic and GABAergic Systems: A Proteomics and Metabolomics Study in Mice by Weckmann K. (5977448)

“…Ketamine, a noncompetitive, voltage-dependent N-Methyl-D-aspartate receptor (NMDAR) antagonist, has been shown to have a rapid antidepressant effect and is used for patients experiencing treatment-resistant depression. …”

Supplementary Material for: Continuous Intragastric Dextrose: A Therapeutic Option for Refractory Hypoglycemia in Congenital Hyperinsulinism by Vajravelu M.E. (5607443)

“…<b><i>Results:</i></b> We studied 32 subjects (13 female) with a median age at IGD initiation of 73 days (range 17–367); median follow-up was 11.2 months (range 5.0–14.2). …”

Data_Sheet_1_The Aha! experience is associated with a drop in the perceived difficulty of the problem.docx by Nadezhda V. Moroshkina (12904751)

“…To test our hypotheses, we developed a novel set of rebus puzzles. A total of 160 participants solved rebuses and provided initial (within 5 s of problem presentation) and retrospective difficulty ratings (following the generation or presentation of a correct solution). …”

Development of a low commercial value fish-sausage from the fish trawling “mix” category by Juliana de Lima Brandão GUIMARÃES (5313665)

“…The shrimp trawling modality produces a large volume of a “mix” category comprising low commercial value fish. …”

A Novel Pyrimidin-Like Plant Activator Stimulates Plant Disease Resistance and Promotes Growth by Tie-Jun Sun (717819)

“…<div><p>Plant activators are chemicals that induce plant defense responses to a broad spectrum of pathogens. Here, we identified a new potential plant activator, 5-(cyclopropylmethyl)-6-methyl-2-(2-pyridyl)pyrimidin-4-ol, named PPA (pyrimidin-type plant activator). …”

CpdA is involved in amino acid metabolism in <i>Shewanella oneidensis</i> MR-1 by Takuya Kasai (478765)

“…<p>Cyclic 3′,5′-adenosine monophosphate (cAMP) phosphodiesterase (CPD) is an enzyme that catalyzes the hydrolysis of cAMP, a signaling molecule affecting diverse cellular and metabolic processes in bacteria. …”

Rescue of Sox10 expression can occur in absence of a rescue of Six1 expression. by Nadège Gouignard (3216114)

“…<p>(a–f) In situ hybridization for Sox10 (a–c) and Six1 (d–f), in embryos injected with CMO (a, <i>n</i> = 29; d, <i>n</i> = 56), MMP28-MOspl (b, <i>n</i> = 40; e, <i>n</i> = 43), or co-injected with MMP28-MOspl and mRNA for MMP28wt-GFP (c, <i>n</i> = 31; f, <i>n</i> = 41). …”

Early detection of pancreatic cancer in mouse models using a novel antibody, TAB004 by Shu-ta Wu (4867354)

“…<div><p>Pancreatic ductal adenocarcinoma (PDA) is the fourth-leading cause of cancer death in the United States with a 5-year overall survival rate of 8% for all stages combined. …”

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress by Clement T. Y. Chan (235112)

“…This is illustrated with the RNA modifications Cm, m⁵C, and m²₂G, which increase following hydrogen peroxide exposure but decrease or are unaffected by exposure to methylmethane sulfonate, arsenite, and hypochlorite. …”

Table_1_The Fate of Altertoxin II During Tomato Processing Steps at a Laboratory Scale.DOCX by Hannes Puntscher (6834581)

“…To investigate potential health concerns implied for consumers, we simulated the storage and food processing steps of intact and blended tomatoes after addition of the highly genotoxic secondary metabolite altertoxin II. We observed a significant decrease in altertoxin II concentrations in samples stored at room temperature and particularly those undergoing thermal treatment by employing a validated LC-MS/MS method. …”

Supplemental Figure 10 from Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity by Dong Joon Kim (280038)

“…Vehicle, herbacetin (100 mg/kg B.W. p.o. or 2 mg/kg B.W. i.p.) or DFMO (1 g/kg B.W. p.o.) was administered by gavage or intraperitoneal injection 5 times per week for 5 weeks. (A) DFMO significantly decreased hearing (measured as prepulse inhibition or PPI) on day 35. …”

Supplementary Material for: Collecting Valid and Reliable Data: Fieldwork Monitoring Strategies in a Health Examination Survey by Kislaya I. (9766340)

“…During fieldwork monitoring through KPI, upon implementation of corrective measures, the participation rate increased 2.5-fold, and a 4.4-fold decrease in non-adherence to standardized survey procedures was observed in the average time distribution for blood pressure measurement. …”

siRNA depletion of PAX9 affects Wnt signaling in MCF10A cells. by Katherine I. Farley-Barnes (9258036)

“…<p>(A) The mRNAs with decreased expression upon PAX9 depletion are enriched for genes that influence the cell cycle and protein synthesis (left). …”

DataSheet1_Design and evaluation of a ball spline wasp-inspired needle.xlsx by Jette Bloemberg (11665612)

“…Furthermore, evaluation in 15-wt%, 10-wt%, and 5-wt% gelatin tissue phantoms showed that decreasing the gelatin concentration decreased the mean slip ratios from 0.35 to 0.19 and 0.18, respectively. …”