NRF2 Activation Restores Disease Related Metabolic Deficiencies in Olfactory Neurosphere-Derived Cells from Patients with Sporadic Parkinson's Disease by Anthony L. Cook (215339)

“…</p> <h3>Results</h3><p>We tested the robustness of our initial findings by including additional cell lines and confirmed that hONS cells from Patients had 20% reductions in reduced glutathione levels and MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt] metabolism compared to cultures from healthy Control donors. …”

DataSheet_1_Identification of drought-responsive phenolic compounds and their biosynthetic regulation under drought stress in Ligularia fischeri.docx by Yun Ji Park (1510729)

“…In contrast, all types of caffeoylquinic acids (CQAs) and flavonol contents were decreased under drought stress. Further, we performed RNA sequencing to examine the molecular changes in these phenolic compounds at the transcriptome level. …”

Table_1_Tropospheric Ozone Alters the Chemical Signal Emitted by an Emblematic Plant of the Mediterranean Region: The True Lavender (Lavandula angustifolia Mill.).xlsx by Candice Dubuisson (12245750)

“…To do so, in controlled conditions, we exposed (i) the entire plant to high but realistic [O₃] (200 ppb for 5 h) and (ii) only the VOCs emitted by lavender to increasing [O₃] (0, 40, 80, 120, and 200 ppb). …”

CCDC66 localizes to the axoneme and regulates primary cilium stability but not cilia formation in IMCD3 cells. by Jovana Deretic (13113617)

“…<i>n</i> > 600 cells for control and >400 cells for CCDC66 depletion. The mean cilia length in CCDC66-depleted cells decreased to 0.67-fold compared to the mean control length. …”

Halogenated Symmetrical Tetraazapentacenes: Synthesis, Structures, and Properties by Jens U. Engelhart (1393285)

“…The targets were obtained by thermal condensation of 2,5-dihydroxyquinone with 4,5-dichloro-, 2,6-dichloro-, and 4,5-dibromo-1,2-phenylenediamine, followed by oxidation with hot acidic dichromate. …”

Association between HDACs and pro-inflammatory cytokine gene expressions in obesity by Mehrnoosh Shanaki (3391955)

“…Our findings showed decreased HDAC5 expression in SAT and elevated HDAC4 expression in VAT from the obese group compared with the non-obese group. …”

Table_1_Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndr... by Zhixiao Xu (3469277)

“…The OBS (where a higher OBS signified an increased prevalence of anti- or pro-oxidant exposures) weighed the 20 factors, while the MetS severity score weighed the five factors.</p>Results<p>After multivariable adjustment, individuals with elevated OBS were found to exhibit a decreased susceptibility to MetS [odds ratio (OR) 0.95; 95% CI 0.94-0.96]. …”

<b>Differences in White Matter Microstructure in Children With Type 1 Diabetes Persist During Longitudinal Follow up: Relation to Dysglycemia</b> by Nelly Mauras (8103110)

Table_1_Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndr... by Zhixiao Xu (3469277)

“…The OBS (where a higher OBS signified an increased prevalence of anti- or pro-oxidant exposures) weighed the 20 factors, while the MetS severity score weighed the five factors.</p>Results<p>After multivariable adjustment, individuals with elevated OBS were found to exhibit a decreased susceptibility to MetS [odds ratio (OR) 0.95; 95% CI 0.94-0.96]. …”

There was a weak effect of temperature treatment on pre-exposure coral samples for the 16s rRNA coral samples, but this was lost after disease inoculation. by Benjamin D. Young (9553231)

“…Points are the Shannon-Weiner alpha metric mean estimates with bars showing calculated confidence intervals. …”

DataSheet_1_Impact of intrafraction motion in pancreatic cancer treatments with MR-guided adaptive radiation therapy.docx by Doris N. Rusu (17624388)

“…Compared to the scheduled plan, the post-treatment plans showed a decrease in the V33Gy, demonstrating the benefit of plan adaptation for 66% of the fractions for the duodenum, 95% for the stomach, 100% for the colon, and 79% for the small bowel.…”

Table_2_Cladribine treatment specifically affects peripheral blood memory B cell clones and clonal expansion in multiple sclerosis patients.xlsx by Christoph Ruschil (9870365)

“…</p>Results<p>The analysis of peripheral blood B cell percentages pointed towards a significant decrease of memory B cells and an increase of naive B cells following cladribine therapy. …”

DataSheet_1_Cladribine treatment specifically affects peripheral blood memory B cell clones and clonal expansion in multiple sclerosis patients.pdf by Christoph Ruschil (9870365)

“…</p>Results<p>The analysis of peripheral blood B cell percentages pointed towards a significant decrease of memory B cells and an increase of naive B cells following cladribine therapy. …”

Table_1_Cladribine treatment specifically affects peripheral blood memory B cell clones and clonal expansion in multiple sclerosis patients.xlsx by Christoph Ruschil (9870365)

“…</p>Results<p>The analysis of peripheral blood B cell percentages pointed towards a significant decrease of memory B cells and an increase of naive B cells following cladribine therapy. …”

2-DG sustained mitochondrial bioenergetic function, reduced mitochondrial Aβ load, and suppressed oxidative stress. by Jia Yao (323339)

“…A, 2-DG significantly increased protein expression of enzymes involved in ketone utilization, including SCOT, ACAT1 and OGDH; In contrast, PDH was not changed by 2-DG (*, P<0.05 compared to Ctrl, bars represent mean value ± SEM); B, 2-DG significantly decreased mitochondrial APP and 16 kD Aβ oligomer level (*, P<0.05 compared to Ctrl, bars represent mean value ± SEM); C, 2-DG significantly decreased protein expression of oxidative stress response markers, including MnSOD, Prdx V, and Hsp60 (*, P<0.05 compared to Ctrl, bars represent mean value ± SEM); D, 2-DG significantly decreased both SOD and MnSOD activity while the total anti-oxidant capacity was slightly increased (*, P<0.05 compared to Ctrl, bars represent mean value ± SEM); E, 2-DG significantly decreased lipid peroxidation (*, P<0.05 compared to Ctrl, bars represent mean value ± SEM).…”

GSH levels was increased in LM treated ARPE-19 cells, and enhanced oxygen consumption was related to <i>de novo</i> GSH synthesis. by Lin Zhao (92451)

“…Values are means ± SEM from three independent experiments. <b>(E)</b> LM increases GSH levels by GCL activation. …”

Top-Down Lipidomics Reveals Ether Lipid Deficiency in Blood Plasma of Hypertensive Patients by Juergen Graessler (261978)

“…Importantly, we observed that in blood plasma of hypertensive individuals the overall content of ether lipids decreased. …”

Hyperosmotic stress in <i>Chlamydomonas</i> induces metabolomic changes in biosynthesis of complex lipids by Zipora Tietel (1943224)

“…<p>To study the early stress response of the green microalga <i>Chlamydomonas reinhardtii</i> CC-503, we exposed cells to hyperosmotic conditions for a period of 5 hours, sampling at eight time points. …”

Simulation of the ring attractor network with flashing input during the wake phase with slow plasticity time constants (details in Methods(4.9)). by Andres Flores-Valle (11114221)

“…A: Full simulation with three wake phases and three sleep phases. We used the same input rotation as in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1009088#pcbi.1009088.g005" target="_blank">Fig 5</a> (rotating input at 0.5<i>Hz</i>). …”

A3F translocations on ssDNA are distinct from A3G, but not due to intersegmental transfer. by Anjuman Ara (540372)

“…This was distinct from A3G that was processive when cytosines were closely spaced (5- to 14- nt apart), reached a maximum processivity when cytosines were 30- to 63- nt apart and then decreased in processivity (filled squares). …”