Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Digital Microfluidic Platform Based on Printed Circuit Board for Affinity Evaluation of Mertansine Aptamers by Dongliu Xiang (10688647)

“…The dissociation constants (<i>K</i>_d) of the two aptamers are 70.9 ± 8.5 nM and 43.6 ± 21.6 nM, respectively. Compared with manual methods, the digital microfluidic platform not only reduced the time for a single determination from 105 to 45 min but also significantly decreased the reagent consumption from 1280 to 30.72 μL. …”

Image_5_Where Are We on the Animal Welfare Map? Using GIS to Assess Stakeholder Diversity and Inclusion.TIFF by Kevin C. Roberts (11828714)

Total, free, and bound thrombin of 10,000 simulations of blood clotting over collagen/ TF under venous flow rate. by Jason Chen (15937)

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Plasma protein levels and thrombin binding sites distribution of the subsets of top and bottom 2% of fibrin concentration of 10,000 simulations. by Jason Chen (15937)

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Fig 5 - by Andrea R. Thurman (5286005)

Image_5_Decreased Evoked Slow-Activity After tDCS in Disorders of Consciousness.PNG by Armand Mensen (516668)

Image_5_Loss of CDYL Results in Suppression of CTNNB1 and Decreased Endometrial Receptivity.TIF by Xiaowei Zhou (1332225)

Image_5_Loss of CDYL Results in Suppression of CTNNB1 and Decreased Endometrial Receptivity.TIF by Xiaowei Zhou (1332225)

Rcan2-mediated decrease in intracellular K⁺ involves Kcnk5b. by Xiaowen Jiang (8291814)

Community weighted mean (CWM) of the three traits that we included in the measure of functional diversity for wood decomposing beetles captured around young (green) and veteran (br... by Ross Wetherbee (10326282)

Fibrin concentration of 10,000 simulations compared to experimental data of blood clotting over collagen/ TF under venous flow rate. by Jason Chen (15937)

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Appearance and RF values of samples under UV 365 nm in various fractions. by Asif Khan (1740271)

Porosity Tuning in Soft-templated Mesoporous Silica: The Influence of Block Copolymer Composition and Concentration by Lysander Q. Wagner (17419267)

“…The block length of the hydrophobic PHA block in the micelle core showed to enable a pore size tuning between 10 and 80 nm according to electron microscopy, physisorption, and small-angle X-ray scattering. …”

MiR-132-3p was downregulated in TGF-<i>β</i>1 stimulated Met-5A cells and miR-132-3p mimics and miR-132-3p inhibitor transfected Met-5A cells. by Yangyang Yin (14323701)

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Dependence of absorbance at 510 nm associated with free available chloride on sulfuric acid concentration in sodium chlorite solution. by Ayuta Kishimoto (16814662)

UPLC-DAD profile (270 nm) of phytocannabinoids in the extracts separated in C18 column. by Bruno Musetti (9527085)

Overexpressions of the AB domain of RPA70 and the β-barrel domain of Ku70 significantly decrease HBoV1 replication in HAE-ALI. by Kang Ning (59789)

Molecular Simulations Probing the Adsorption and Diffusion of Ammonia, Nitrogen, Hydrogen, and Their Mixtures in Bulk MFI Zeolite and MFI Nanosheets at High Temperature and Pressur... by Roshan Patel (10727011)

“…Using force-field-based molecular simulations, we evaluate the performance of bulk all-silica MFI zeolite and a 3 nm thick all-silica MFI nanosheet for ammonia/nitrogen/hydrogen separations at moderate temperature and pressure conditions (<i>T</i> = 373 K, <i>p</i> = 5 bar) as well as conditions relevant for a membrane-based reactor–separator process (<i>T</i> = 523 or 623 K, <i>p</i> = 80 bar). …”

Comparison of ∑PCDD/F, PCDD/F TEQ, ∑PCB, PCB TEQ and ∑TEQ concentrations in eggs analyzed in this study and other relevant studies (pg/g ww except for ∑PCB ng/g ww, geometric mean... by Matti Viluksela (321291)