Carbonic Anhydrase Generates CO₂ and H⁺ That Drive Spider Silk Formation Via Opposite Effects on the Terminal Domains by Marlene Andersson (610369)

“…Surprisingly, the terminal domains respond in opposite ways when pH is decreased from 7 to 5: Urea denaturation and temperature stability assays show that NT dimers get significantly stabilized and then lock the spidroins into multimers, whereas CT on the other hand is destabilized and unfolds into ThT-positive β-sheet amyloid fibrils, which can trigger fiber formation. …”

Ameliorative impact of Juniperus Macrocarpa extract on methotrexate-induced hepatic damage in rats by Shahad Hassan Hadi (20141025)

“…Rats in groups 3 and 4 were given daily dosages of 100 mg and 200 mg of Juniperus macrocarpa aqueous extract, respectively, for two weeks before receiving a single intraperitoneal MTX injection. Juniperus macrocarpa extracts at both low and high doses substantially alleviated the MTX-provoked biochemical alterations, as evidenced by decreased levels of inflammatory parameters including TNF-α and IL-6 and hepatic enzymes including ALT, AST, and ALP. …”

Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson's Disease by Kyota Fujita (258978)

“…The concentration-dependency of H₂ showed that H₂ as low as 0.08 ppm had almost the same effect as saturated H₂ water (1.5 ppm). MPTP-induced accumulation of cellular 8-oxoguanine (8-oxoG), a marker of DNA damage, and 4-hydroxynonenal (4-HNE), a marker of lipid peroxidation were significantly decreased in the nigro-striatal dopaminergic pathway in mice drinking H₂-containing water, whereas production of superoxide (O₂•⁻) detected by intravascular injection of dihydroethidium (DHE) was not reduced significantly. …”

Table_1_Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.XLSX by Hantao Wang (760364)

“…Finally, miRNAs targeting BTF3 were predicted and validated. Decreased miR-497-5p expression is responsible for higher levels of BTF3 post-transcriptionally. …”

Feeding effects of cottonseed and its co-products on the meat proteome from ram lambs by Tiago do Prado Paim (5671568)

“…The effect of gossypol (a compound present in cotton co-products) in ruminant metabolism and meat quality is not yet clear. …”

Effect of <i>Trypanosoma cruzi</i> AP-1 γ subunit (TcAP1-γ) gene knockout on cruzipain expression and localization. by Claudia Maria do Nascimento Moreira (4287679)

“…In γKO epimastigotes, the levels of the zymogen form (57 kDa) of TcCZP were increased, while the levels of the mature enzyme (51 kDa) were decreased (to a faint band) compared with the WT. Labeling for the <i>T</i>. …”

Different expressions of immune components in ascites of early- and advanced-stage ovarian cancer patients. by Yu-Li Chen (126600)

“…C1, IL-4; C2, TNF-α; C3, TGF-β; C4, IL-6; C5, IL-10; C6, IFN-γ. <i>Note</i>: The IL-4 and TNF-α concentrations decreased while the TGF-β, IL-6, IL-10, and IFN-γ concentrations increased from early to advanced stage.…”

Table_3_Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.XLSX by Hantao Wang (760364)

“…Finally, miRNAs targeting BTF3 were predicted and validated. Decreased miR-497-5p expression is responsible for higher levels of BTF3 post-transcriptionally. …”

Computer simulations confirm involvement of <i>I_m</i> and <i>I_h</i> in resonance and allow the dissection of their respective contributions at different volta... by Jorge Vera (432199)

“…<i>C, D</i>, Same as in A, B, but at −65 mV; <i>I_m</i> removal clearly reduced resonance (Q = 1.12, compared to 1.35 for control; <i>f_res</i> decreased from 3.7 to 2.0 Hz). …”

Image_1.pdf by Sipla Aggarwal (4912828)

“…Four non-segregating RNAi lines of wheat were selected for detailed study (S3-D-6-1; S6-K-3-3; S6-K-6-10 and S16-D-9-5). Homozygous transgenic RNAi lines at T₄ seeds with a decreased transcript of TaIPK1 showed 28–56% reduction of the PA. …”

Supplementary Material for: Trends in incidence of intracerebral hemorrhage and its bleeding sites from 1985 to 2017 in Japanese rural communities by figshare admin karger (2628495)

“…The proportions of bleeding sites were 37%, 29%, and 31% for putamen in 1985-1995, 1996-2006, and 2007-2017, respectively; the corresponding proportions were 24%, 35%, and 18% for thalamus; 10%, 10%, and 21% for lobes; 2%, 8%, and 12% for cerebellum; and 8%, 6%, and 5% for brain stem. Conclusion: The age-adjusted incidence declined by 33% from the 1990s with a large reduction in the early 1990s in Japanese rural communities. …”

High-saturated fatty meals with orange juice intake have subjective appetite sensations suppressed: Acute, postprandial study by ALESSANDRA DA SILVA (10363904)

“…Methods: This acute, postprandial study included 39 healthy women (aged 20 to 40 years): 22 participants received a high-monounsaturated fat meal (MUFA) (≈1000 kcal, 56.3% Energy from MUFA) and 17 participants received a high-saturated fat meal (SFA) (≈1000 kcal, 37.6% Energy from SFA). …”

Effects of SR on nNOS and GFAP-IR in the CPu. by M. Paola Castelli (566641)

“…<p>A. Rats received injections of 1/kg Δ9-THC or VEH at 0.5, 12, 24, 36 and 48 h after the last METH administration (Post-treatment, POST) and were sacrificed 3 days after the last METH injection. …”

SDF-1α treatment induces reorganization of GM1- and flotillin-microdomains but does not affect DRM localization of flotillins in T cells. by Lawrence Rajendran (185591)

“…Increased ERK phosphorylation accompanied chemokine treatment at 5 min and decreases with time. <i>Lower panel</i>: Blotting with anti-ERK antibody shows the total ERK content.…”

CXCR4 regulates tumor progenitor cell adhesion. by Anna Dubrovska (105746)

“…The cells were counted in three wells per condition using a phase-contrast microscope.*-p value<0.05. (B) The expression level of α2, α5, and β3 integrins subunits is strongly upregulated in CD133⁺/CD44⁺ DU45 compared to CD133⁻/CD44⁻ DU45 cells. …”

Data_Sheet_1_Reproductive-dependent effects of B vitamin deficiency on lifespan and physiology.PDF by Guixiang Yu (17273653)

“…Notably, the dietary absence of VB₁, VB₃, VB₅, VB₆, or VB₇ significantly decreased the lifespan of wild-type females, yet demonstrated relatively little effect on ovo^D1 infertile mutant females’ lifespan. …”

Image_1_Mortality Rate of Lymphoma in China, 2013–2020.tif by Weiping Liu (47182)

“…<p>Lymphoma is a malignant disease that threatens human health and imposes a significant burden on the society burden; however, there are limited accurate mortality data on lymphoma in China. …”

Table_2_Inactivation of Prefrontal Cortex Delays Emergence From Sevoflurane Anesthesia.docx by Emma R. Huels (10321976)

“…Ninety minutes after injection, rats were anesthetized with 2.5% sevoflurane and the time to loss of righting reflex, a surrogate for loss of consciousness, was measured. …”

Data_Sheet_2_An Environmental Flow Framework for Riverine Macroinvertebrates During Dry and Wet Seasons Through Non-linear Ecological Modeling.XLSX by Qingyi Luo (9501648)

“…<p>A suitable environmental flow is critical for the functional maintenance of riverine ecosystems. …”

Novel Glycan Biomarkers for the Detection of Lung Cancer by James N. Arnold (2217103)

“…Lung cancer has a poor prognosis and a 5-year survival rate of 15%. …”