The interaction between RE1-silencing transcription factor (REST) and heat shock protein 90 as new therapeutic target against Huntington’s disease by Raúl Orozco-Díaz (7067624)

“…In Huntington´s Disease an inherited degenerative disease, caused by a CAG expansion in the 5´coding region of the gene, the mutant huntingtin protein (mHtt), causes that REST enters pathologically into the nucleus of cells, resulting in the repression of neuronal genes including BDNF, resulting in the progressive neuronal death. …”

DataSheet_1_Assessment of fishery management parameters for major prey fish species in the lower reaches of the Songhua River.docx by Wanqiao Lu (16381344)

“…In addition, the growth length coefficients of the five prey fish species were all greater than 0.2, indicating that the prey fish were growing at a faster rate, and the range of the growth performance indicators were 3.49 ~ 4.37. …”

Data_Sheet_1_Randomized, Placebo-Controlled, Double-Blind and Open-Label Studies in the Treatment and Prevention of Acute Diarrhea With Enterococcus faecium SF68.PDF by Thomas Greuter (6527111)

“…The primary endpoint of the treatment study was met with a decreased time to resolution of diarrhea in SF68-treated patients compared to controls (median 3 vs. 4 days, p < 0.001). …”

Image_1_Xanthine Oxidoreductase Is Involved in Chondrocyte Mineralization and Expressed in Osteoarthritic Damaged Cartilage.jpg by Sonia Nasi (383541)

“…We showed both in murine primary chondrocyte and chondrogenic ATDC5 cells, that mineralization was inhibited by two different XOR inhibitors, febuxostat and allopurinol. …”

Enhancing both oral bioavailability and brain penetration of puerarin using borneol in combination with preparation technologies by Tao Yi (504558)

“…The <i>in vitro</i> BBB model study showed the permeability of puerarin was increased significantly (<i>p </i>< 0.05) and the value of transepithelial electrical resistance at 2 h was decreased significantly (<i>p </i>< 0.01) when the concentration of borneol was over 12.5 μg/mL compared with the control group. …”

Table_1_Pseudomonas stutzeri and Kushneria marisflavi Alleviate Salinity Stress-Associated Damages in Barley, Lettuce, and Sunflower.docx by Sonia Szymańska (3823558)

“…The aim of this study was to determine the effect of selected halotolerant plant growth-promoting endophytes (PGPEs, Pseudomonas stutzeri ISE12 and Kushneria marisflavi CSE9) on the growth parameters of barley (Hordeum vulgare), lettuce (Lactuca sativa), and sunflower (Helianthus annuus) cultivated under salt stress conditions. A negative effect of two higher tested salinities (150 and 300 mM NaCl) was observed on the growth parameters of all investigated plants, including germination percentage and index (decreasing compared to the non-saline control variant in the ranges 5.3–91.7 and 13.6–90.9%, respectively), number of leaves (2.2–39.2%), fresh weight (24.2–81.6%); however, differences in salt stress tolerance among the investigated crops were observed (H. annuus > H. vulgare > L. sativa). …”

Image_2_Xanthine Oxidoreductase Is Involved in Chondrocyte Mineralization and Expressed in Osteoarthritic Damaged Cartilage.JPEG by Sonia Nasi (383541)

“…We showed both in murine primary chondrocyte and chondrogenic ATDC5 cells, that mineralization was inhibited by two different XOR inhibitors, febuxostat and allopurinol. …”

Image_1_Gypenosides Prevent and Dissolve Cholesterol Gallstones by Modulating the Homeostasis of Cholesterol and Bile Acids.tif by Qian Zhuang (621842)

“…GPs increased the hepatic expression of genes encoding the cytochrome P450 (Cyp) enzymes Cyp7a1, Cyp7b1, and Cyp8b1, while decreasing the hepatic expression of genes encoding the adenosine triphosphate-binding cassette (Abc) transporters Abcg5 and Abcg8. …”

Data_Sheet_1_Distinct patterns of fasting plasma glucose and lipid profile levels over time in adults tested positive for HIV on HAART in Shanghai, China, revealed using growth mix... by Jingjing Lang (14434158)

“…Three FPG trajectory subgroups were identified as FPG low-stable (62.3%), medium-stable (30.5%), and high-increasing (7.2%). Furthermore, three subgroups of TG and TC dual-trajectories were identified as TG and TC high-slight increasing (13.7%), low-rapid increasing (27.6%), and a subgroup of medium-stable TC and slight-decreasing TG (58.7%). …”

Rapid Recovery of Visual Function Associated with Blue Cone Ablation in Zebrafish by Gordon F. Hagerman (3366290)

“…This visually mediated behaviour decreased to about 5% or 20% of control levels following ablation of UV or blue cones, respectively (P<0.05). …”

Data_Sheet_1_Optimization of tomato (Solanum lycopersicum L.) juice fermentation process and analysis of its metabolites during fermentation.zip by Lei Zhao (144153)

“…Carbohydrates were fully retained at the end of fermentation.The content of galactitol increased from the initial 5.389 to 6.607 while the content of cytarabine decreased by 29% and uridine by 44%. …”

Table_1_Coix Seed Oil Exerts an Anti–Triple-Negative Breast Cancer Effect by Disrupting miR-205/S1PR1 Axis.docx by Ting Fang (155126)

“…<p>Coix Seed Oil (CSO) possesses a wide range of pharmacological activities. Kanglaite Injection, a commercial product of CSO, has been used clinically as an anticancer drug in China for decades. …”

DataSheet_1_Coix Seed Oil Exerts an Anti–Triple-Negative Breasty Cancer Effect by Disrupting miR-205/S1PR1 Axis.zip by Ting Fang (155126)

“…<p>Coix Seed Oil (CSO) possesses a wide range of pharmacological activities. Kanglaite Injection, a commercial product of CSO, has been used clinically as an anticancer drug in China for decades. …”

Distribution of differences of DNA methylation between normal mammary glands and mammary carcinomas. by Masaru Takabatake (3202710)

“…The curve shows a simulated normal distribution (mean = 0, standard deviation = 2.5) with the same spread as the data, but centered on zero to indicate the null hypothesis of no global trend. …”

Data Sheet 2_Red mite (Panonychus citri) attack amplifies citrus rootstock-driven responses in physiological and biochemical traits, VOC emission, and expression of defence-related... by Tommy Rioja (22179742)

“…Photosynthetic pigments declined across all combinations after infestation, while soluble sugars and flavonoids decreased in susceptible rootstocks. VOC profiles shifted both qualitatively and quantitatively in a rootstock-dependent manner. …”

Three-year safety and two-year effectiveness of etanercept in patients with rheumatoid arthritis in Japan: Results of long-term postmarketing surveillance by Hisashi Yamanaka (137140)

“…Mean baseline DAS28-4/ESR for the 581 patients included in effectiveness analysis was 5.42, which decreased to 3.32 at 2 years. Eighty-two percent of patients achieved a moderate/good response at 2 years.…”

DataSheet1_Vegetation Dynamics and its Response to Climate Change in the Yellow River Basin, China.docx by Cun Zhan (12454887)

“…Results indicated that the annual NDVI in the YRB decreased spatially from southeast to northwest, and peaked in August. …”

Polarity-Induced Reactive Wetting: Spreading and Retracting Sessile Water Drops by William S. Y. Wong (2795890)

“…Drops contacting the transition spread before retracting, occurring over the time scale of a few seconds. This phenomenon contradicts current understanding, exhibiting a uniquely (1) decreasing advancing contact angle and (2) increasing receding contact angle. …”

image1_Allergic Asthma-Induced Cognitive Impairment is Alleviated by Dexamethasone.pdf by Mengli Ren (6707078)

“…<p>Allergic asthma is a typical chronic inflammatory disease of respiratory tract. …”

Table_2_Omics-Based Mechanistic Insight Into the Role of Bioengineered Nanoparticles for Biotic Stress Amelioration by Modulating Plant Metabolic Pathways.DOCX by Madhuree Kumari (3699274)

“…The particles reduced disease severity by 70–80% at 5 μg/ml without showing phytotoxicity. It elicited plant immunity by a significant reduction in reactive oxygen species (ROS), decreases in stress enzymes by 0.6–19.8-fold, and emergence of autophagy. …”