Structure–Activity Relationship of 3‑Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors by Mirko Scortichini (4007366)

“…We now expand the structure–activity relationship of pyrimidine nucleotides as human CD73 inhibitors. 4-Chloro (MRS4598 <b>16</b>; <i>K</i>_i = 0.673 nM) and 4-iodo (MRS4620 <b>18</b>; <i>K</i>_i = 0.436 nM) substitution of the <i>N</i>⁴-benzyloxy group decreased <i>K</i>_i by ∼20-fold. …”

Structure–Activity Relationship of 3‑Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors by Mirko Scortichini (4007366)

“…We now expand the structure–activity relationship of pyrimidine nucleotides as human CD73 inhibitors. 4-Chloro (MRS4598 <b>16</b>; <i>K</i>_i = 0.673 nM) and 4-iodo (MRS4620 <b>18</b>; <i>K</i>_i = 0.436 nM) substitution of the <i>N</i>⁴-benzyloxy group decreased <i>K</i>_i by ∼20-fold. …”

Ecto-5’-NT expression in D283 decreases the growth of tumor cells. by Angélica R. Cappellari (817261)

5-fluorouracil decreases rates of persistent and reappearing actinic keratoses: The VAKCC Trial by Moniyka Sachar (9399032)

Thermodynamic parameters of CR adsorbed onto magnetic Co_0.5Mn_0.5Fe₂O₄ nanoparticles. by Xiajun Zhang (3161865)

Subjects:

Reproductive transition paralleled a significant decrease in LDH5 and LDH1 expressions in nonTg hippocampus. by Fan Ding (302565)

“…<p>A. NonTg hippocampus demonstrated a an age-related decrease in LDH5 expression from 6 to 15 months of age, which was significant between 6 and 9, 9 and 12 months of age. …”

Pretreatment of Huh-7.5.1 cells with PF-429242 results in a dose-dependent decrease in intracellular DENV-2 NS1 protein abundance and a 3-log decrease in extracellular viral titer. by Anastasia Hyrina (3860455)

Inhibition of NLRP3 inflammasomes decreased 5-FU-induced cell death. by Kaya Yoshida (658943)

An ATR-specific inhibitor decreases HBoV1 infection of HAE-ALI. by Xuefeng Deng (138723)

An ATM-specific inhibitor decreases HBoV1 infection of HAE-ALI. by Xuefeng Deng (138723)

SDG decreases iron-induced caspase 3/7 activity in H9c2 cells. by Stephanie Puukila (568109)

Exercise decreased the increased expression of cofilin in the cortex during aging. by Yan Li (23143)

Reversion to susceptibility was consistent with decreasing relative <i>vanA</i> copy number. by Samuel E. Blechman (19506884)

Trabectedin induced apoptosis in a dose-dependent manner as measured by the Muse™ Annexin V and Dead Cell assay. by Eda Acikgoz (816259)

“…Cells were treated with 0.1, 1, 10 and 100 nM trabectedin for 48 h. After incubation time cells were collected and the phosphatydilserine externalization was evaluated using Annexin V protocol as describe. …”

Molecular Simulations Probing the Adsorption and Diffusion of Ammonia, Nitrogen, Hydrogen, and Their Mixtures in Bulk MFI Zeolite and MFI Nanosheets at High Temperature and Pressur... by Roshan Patel (10727011)

Subjects:

NM proteins binding the XmnI sequence in PCa cell lines. by Paola Barboro (316507)

“…The decrease in 22Rv1 and PC3 with respect LNCaP cells was significant (*P = 0.004, **P<10⁻⁵). …”

Decrease in GABA in APP mice. by Ksenia V. Kastanenka (3692380)

The suppressive effect of an A2AR agonist on the proliferation of CFSE-labeled αβ T cells is decreased in the presence of A2AR⁺ γδ T cells. by Dongchun Liang (636452)

TMZ-Se triggers a greater autophagic response than TMZ, and inhibition of autophagy decreases the efficacy of TMZ-Se against glioma cells. by Yan Cheng (149222)

Zero-loss and low-loss EELS spectra of water vapor at various pressures (300kV, room temperature). by Cathal Cassidy (1758703)

“…Zero-loss peak intensity decreases, and energy loss intensity increases, as a function of water vapor pressure, as expected. …”