Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Pretreatment with SDG prevents iron induced decrease in H9c2 cell size. by Stephanie Puukila (568109)

S1 Dataset - by Nelmo Jordão Manjate (16324619)

“…We conducted a retrospective cost analysis from the provider’s perspective using a bottom-up, micro-costing approach, and compared the direct costs of two nasopharyngeal Ag-RDTs (Panbio and Standard Q) against the costs of three nasal Ag-RDTs (Panbio, COVIOS and LumiraDx), and RT-PCR. …”

VEGFR2/VEGF-A ligand binding decreased ranibizumab and aflibercept mediated CCL2, CCL5, and CX3CL1 mRNA and protein levels in HCAECs. by Clare Arnott (2557705)

HEWL interacts with dissipated oleic acid micelles, and decreases oleic acid cytotoxicity - Fig 1 by Qin Huang (49441)

Subjects:

Relative mRNA levels of DNA methyltransferases (<i>Dnmt1</i>, <i>Dnmt3a</i>, and <i>Dnmt3b</i>; a) and microRNAs (<i>mir-29b</i>, <i>mir-148a</i>, and <i>mir-152</i>; b) in porcine... by Shuang Liang (211832)

Subjects:

Cardamonin decreased the protein expression of lipogenic proteins. by Peiguang Niu (17044532)

Chemokines, with the exception of CXCL1 and MCP-1, decrease acutely following 5 Gy IR. by Jordan A. Gunning (18143970)

Aggrecan knockdown ATDC5 chondroprogenitor cells have decreased Alcian blue staining and absorbance levels compared to control cells after ITS stimulation. by Juanita K. Hodax (6848540)

E2-induced PKCδ activation is responsible for the ASL height decrease in CuFi-1 cells. by Vinciane Saint-Criq (479729)

Pendrin gene ablation increases force/cross-sectional area and decreases thickness of the aorta. by Roy L. Sutliff (485240)

Ethanol withdrawal (EW) decreases GluN2A subunit levels. by Marina Rubio (345805)

“…<p>NMDA subunit protein levels measured by Western blot analysis: GluN2A levels (B) decrease during ethanol withdrawal, whereas the levels of GluN1 (A) and GluN2B (C) remain unaltered. …”

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

Subjects:

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

Subjects:

Retinoic acid decreases intracellular K⁺ in pectoral fin buds via transcriptional activation of the calcineurin inhibitor <i>rcan2</i>. by Xiaowen Jiang (8291814)

HPV16 PsV infection decreases following SLPI treatment or anti-annexin A2 antibody inhibition of A2t. by Andrew W. Woodham (140650)

Acid wash decrease, but do not attenuate sCT mediated prolonged cAMP and β-arrestin signaling. by Kim Vietz Andreassen (317792)

Infection decreases short chain phospholipids in the intestines of <i>V</i>. <i>cholerae</i>-infected flies. by Audrey S. Vanhove (4090594)

Damsin (D) and ambrosin (A) treatment decreases the CSC population. by Wendy Soria Sotillo (4408105)

Mutation of four arginine residues in P34 leads to a decrease in binding between P34 and L5. by Anyango D. Kamina (4034165)