Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2‑Aminoquinoline Inhibitors by Maris A. Cinelli (1309419)

“…We previously developed a class of membrane-permeable 2-aminoquinoline inhibitors and later rearranged the scaffold to decrease off-target binding. …”

AEA decreases mPGES-1 mRNA and protein levels. by Claudia A. Vercelli (284964)

MVEC microvessel formation is restricted in hydrogels exhibiting increased stiffness or decreased concentration of adhesive peptides. by Rebecca A. Scott (488956)

“…(<b>E</b>) Total tubule length (mm/mm²) and (<b>F</b>) tubule diameter decreased significantly as hydrogel wt% increased. …”

The interaction between E1A and PKA subunits is required for full expression of HAdV-5 E3 and E4 transcripts. by Cason R. King (2633092)

“…Results for the HAdV-5 E1A (A), E1B (B), E2 (C), E3 (D) and E4 (E) transcription units are shown. …”

Postnatal decrease in PV+ cortical interneurons in Fgfr1 mutant mice. by Karen Müller Smith (613941)

“…Immunostaining for GFAP, Neun, Ng2, Olig2 and GFP in cortex of adult TgFgfr1-GFP mice (<b>D, E, F</b>). …”

The functional half-life of WNV decreases in the presence of virus-specific antibody. by Kimberly A. Dowd (129927)

Excel spreadsheet containing, in separate sheets, the numerical data for figure panels Figs 1B, 1C, 1E, 1F, 1G, 1I, 1K, 1M, 1N, 1O, 2B, 2C, 2E, 2F, 2G, 2I, 2K, 2M, 2N, 3A, 3B, 3C,... by Le Liang (2144725)

SH-SY5Y cells are responsive to acute insulin stimulation and altered insulin signaling impacts choline uptake by CHT. by Katherine J. Fishwick (768451)

Subjects:

The VPS C846G mutation decreases the stability of VPS11 protein. by Jinglan Zhang (401545)

A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization-2 by Chandrashekhar D Kamat (60176)

“…Acute hypoxia (2.5%0; 4 hours) ("AH") was used as a positive control for the induction of proteins. …”

TH588 effectively decreases cellular survival in heterogeneous neuroendocrine tumor cells. by Elke Tatjana Aristizabal Prada (833927)

Increased AHP Amplitude and decreased AP firing in the presence of kainic acid is dependent on the GluR5 subunit. by Barbara Gisabella (330774)

“…<b>C</b>, <b>D</b>, UBP296 application is associated with an increase of AHP and decrease of AP firing rate in SO of CA2/3 fast-spiking interneurons from PICRO-treated rats. …”

Changes in cyanobacteria fluorescence with 75 μg/mL H₂O₂ for 5, 8, 17 and 24 days. by Emma T. Brentjens (17295999)

Subjects:

Amino acids 605 and 606 of the PB2 ‘627’ domain are involved in interaction with NP. by Ho-Pan Hsia (4768638)

Astrocytes express a ligand for NKp44 and increasing concentrations of HIV 3S peptide decreases its expression. by Kelly E. Bowen (4857370)

Supplementary Material for: Anti-<b><i>Ascaris</i></b> IgE as a Risk Factor for Asthma Symptoms among 5-Year-Old Children in Rural Bangladesh with Even Decreased <b><i>Ascaris</i></b> Infection Prevalence by Takeuchi H. (12022622)

“…The association of anti-<i>Ascaris</i> IgE with increased asthma symptoms among children from a general population with a mild to moderate <i>Ascaris</i> infection prevalence was investigated. …”

Decreased biomechanical stability of bones from <i>Col1a1-Krm2</i> transgenic mice. by Jochen Schulze (365258)

“…(D) Cortical thickness (C.Th.) and bone mineral density (vBMD) are decreased in <i>Col1a1-Krm2</i> transgenic mice compared to wildtype littermates. …”

Aquaporin 2 Mutations in <i>Trypanosoma brucei gambiense</i> Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol by Fabrice E. Graf (469055)

“…Here we describe two different kinds of <i>TbAQP2</i> mutations found in <i>T. b. gambiense</i> field isolates: simple loss of <i>TbAQP2</i>, or loss of wild-type <i>TbAQP2</i> allele combined with the formation of a novel type of <i>TbAQP2/3</i> chimera. The identified mutant <i>T. b. gambiense</i> are 40- to 50-fold less sensitive to pentamidine and 3- to 5-times less sensitive to melarsoprol than the reference isolates. …”

FGF10 dose dependency of the cellular response in E13.5 (black) and E14.5 (blue) epithelium. by Hisako Takigawa-Imamura (3175320)

Decreased eIF2B GEF activity in eIF2B-mutated patients' lymphoblasts (LLB). by Laetitia Horzinski (156394)