Schematic representation of the <i>in vitro</i> PRR assay. by Laura M. Sanz (181325)

“…<p><b>A</b>. Intraerythrocytic <i>P. falciparum</i> cultured at 0.5% parasitemia and 2% hematocrit is treated with drugs. …”

Bcr-Abl activity detection using Abl substrate peptide in the human CML cell line K562. by Tzu-Yi Yang (379403)

“…Phosphorylated endogenous proteins Abl, STAT5 and CrkL, as well as β-tubulin as a loading control, were detected as described in the Materials and Methods. …”

Hsp90 is required for the stability of stress granule and P-body proteins. by Teresa R. O’Meara (720286)

“…AP-MS was performed on <i>HSP90</i>^<i>E36A</i><i>-GFP/HSP90</i> cells grown at 30°C in the presence or absence of 8 μg/mL fluconazole (Flu) or 100 nM caspofungin (Casp). …”

Cell growth/proliferation-suppression by TPIP-C2 cDNA in HeLa cells. by Rasmi Rekha Mishra (193860)

“…<p>(A) HeLa cells were transfected with pCDNA-TPIP-C2 plasmid DNA (2.5, 5.0 and 10 µg DNA in a total of 10 µg of DNA per 6-well plate or with pCDNA-TPIP-C2 plasmid (1, 2, 3 and 5 µg DNA) in a total of 5 µg DNA per well in 6-well plate in duplicates, stable G418-resistant colonies were selected by 0.6 mg/ml G418 for three weeks, and their number was counted. …”

EVA model yields realistic first percept durations. by Quynh-Anh Nguyen (847240)

“…<p>A: Mean percept durations (top) and fitted <i>α</i> value (bottom) from gamma distribution of first <i>I</i> (blue) and first <i>S</i> (red) percepts from behavioral experiment for <i>DF</i> = 3,5,7. …”

<i>In vivo</i> inhibition of ADAM15 activity reduces tumor growth. by Guadalupe Lorenzatti Hiles (2547727)

“…Bars represent mean tumor weight (mg) ± SD (<i>5A</i>,<i>B</i>).</p>…”

GBE treatment improved mitochondrial capacity. by Virginie Rhein (243241)

“…Post-hoc analysis for single experimental respiratory conditions: GBE treatment effect, paired student's t-test, number of pairs n = 5: #, p<0.05, ##, p<0.01; ###, p<0.001 GBE treated versus corresponding untreated cells; and effect of Aβ, unpaired student's t-test, n = 5, **, p<0.01; ***, p<0.001 APP versus control cells). …”

Supplementary Material for: Central Adrenal Insufficiency Could Not Be Confirmed by Measurement of Basal Serum DHEAS Levels in Pubertal Children by Vaiani E. (3419732)

“…<b><i>Background:</i></b> Central adrenal insufficiency (CAI) is due to a decrease of CRH and/or ACTH secretion. ACTH-dependent dehydroepiandrosterone sulphate (DHEAS) has been postulated as a possible marker of adrenal function in adult patients. …”

INFS as a transducer of NGF signals to ssTF. by Yu-Wei Lee (432337)

“…NGF stimulates the MAP/ERK pathway resulting in increased RSK1 activity <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0068931#pone.0068931-Xing1" target="_blank">[11]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0068931#pone.0068931-Silverman1" target="_blank">[13]</a>, which is known to promote the release of newly synthesized FGFR1 from pre-Golgi membranes into the cytosol and accumulation in the cell nucleus <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0068931#pone.0068931-DunhamEms2" target="_blank">[33]</a>. RSK1 binding to FGFR1 in the nucleus decreases FGFR1 mobility promoting the FGFR1 nuclear retention accumulation <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0068931#pone.0068931-DunhamEms1" target="_blank">[32]</a>. …”

Ca²⁺ responses after light stimulation of <i>cTMT-L</i>-expressing cells. by Mutsuko Kato (3353849)

“…Relative bioluminescence signals (Lt/L0) of cTMT-L-expressing cells decreased following blue light pulses (470–490 nm; 10 s at 0.2 μW/mm²; blue arrows), but not with green light pulses (535–555 nm; 10 s at 0.2 μW/mm²; green arrows). …”

Transplanted MDSPCs assist in functional recovery of critically-sized sciatic nerve defects. by Mitra Lavasani (343357)

“…(<b>B-D</b>) Quantification of paw print analyses, indicating that MDSPC transplantation increases the ability of the mice to walk normally, displayed a (<b>B</b>) decrease in toe spread factor, (<b>C</b>) decrease in print length factor, and (<b>D</b>) an increase in SFI (sciatic functional index) compared to PBS-treated mice. …”

DataSheet1_The pharmacokinetic study of tacrolimus and Wuzhi capsule in Chinese liver transplant patients.docx by Jinlong Qu (6893951)

“…We found that 1) WZC could influence the metabolism of tacrolimus, which shortened the Tmax of tacrolimus and decreased V/F and CL/F. 2) Moreover, our results showed that, in donors, the CL/F of tacrolimus were significantly lower in CYP3A5 (CYP3A5*1) expressers (decreased from 24.421 to 12.864) and non-expressers (decreased from 23.532 to 11.822) when co-administration with WZC. …”

DataSheet2_The pharmacokinetic study of tacrolimus and Wuzhi capsule in Chinese liver transplant patients.docx by Jinlong Qu (6893951)

“…We found that 1) WZC could influence the metabolism of tacrolimus, which shortened the Tmax of tacrolimus and decreased V/F and CL/F. 2) Moreover, our results showed that, in donors, the CL/F of tacrolimus were significantly lower in CYP3A5 (CYP3A5*1) expressers (decreased from 24.421 to 12.864) and non-expressers (decreased from 23.532 to 11.822) when co-administration with WZC. …”

Fbxw8 is essential for morphogenesis of the Golgi apparatus in neurons. by Nadia Litterman (221903)

“…<p>(A) Granule neurons transfected at DIV2 with the U6/fbxw8-1, U6/fbxw8-2, or control U6 RNAi plasmid together with the GFP expression plasmid were fixed at DIV5 and were subjected to immunocytochemistry with the GFP and GM130 antibodies. …”

Gradual increase in the extent of γ-secretase saturation with its substrate leads to gradual changes from the biphasic to the standard dose-response curves. by Željko M. Svedružić (105215)

“…Further increase in the substrate (i.e. cDNAwtC99 >250 ng/mL) leads to decrease in Aβ 1–40 secretion (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050759#pone-0050759-t002" target="_blank">Table 2B</a>), which indicates that the substrate can also bind to the inhibition site (i.e. antagonism between complex <b><u>5</u></b> and complex <b><u>6</u></b>).…”

Effect of PEG-8000 on EGFR, cyclin D1 and p21 expression in SCC-25 cells-For these studies, western blot analysis was performed on lysates obtained from SCC-25 cell treated for 24... by Ramesh K. Wali (305603)

“…<p>As shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0038047#pone-0038047-g005" target="_blank">Figure 5A</a>, consonant with the <i>in vivo</i> experiments PEG caused a significant decrease EGFR (∼45% compared to vehicle control; p<002) and cyclin D1 (∼57% compared to control vehicle; p<0.005) expression. …”

Transducer mechanisms activated by D1-like receptors. by Catalina Valdés-Baizabal (701863)

“…The use of H89 in the intracellular solution decreased the inhibitory effect of A-68930 from 29 ± 4% to 16 ± 5% at −10 mV (<i>P</i> = 0.08). …”

Evolutionary Consequences of Altered Atmospheric Oxygen in <em>Drosophila melanogaster</em> by Marc Charette (198776)

“…<div><p>Twelve replicate populations of <em>Drosophila melanogaster</em>, all derived from a common ancestor, were independently evolved for 34+ generations in one of three treatment environments of varying PO₂: hypoxia (5.0–10.1 kPa), normoxia (21.3 kPa), and hyperoxia (40.5 kPa). …”

Treatment of landfill leachate using Fenton Processes and Photo-Fenton Solar by Fábio Moraes da Costa (5376350)

“…These conditions led to a decrease in the toxicity of leachates' coefficient values to a degree equal to 50 % - for Aliivibrio fischeri greater than 50% - indicating a more suitable leachate for further biological treatment.…”

<i>Def6</i> RNA rescues the <i>def6</i> MO-induced phenotype. by Katerina Goudevenou (199855)

“…ANOVA single factor and two-tailed Student's <i>t</i>-tests showed a significant (p<0.001; three asterisks) increase in the angle after injection of 2.5 ng <i>def6</i> MO and a significant (p<0.001; three asterisks) decrease in the angle after addition of <i>def6</i> RNA. …”