Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary... by Martina Korfei (2202892)

“…In agreement, both drugs decreased protein level of phosphorylated (p)-STAT3, a transcription factor mediating profibrotic responses, in treated IPF-fibroblasts. …”

Table1_Pan-cancer analysis identifies proteasome 26S subunit, ATPase (PSMC) family genes, and related signatures associated with prognosis, immune profile, and therapeutic response... by Hui Jia (638620)

“…Notably, they all shared a positive association with increased TMB, TIDE score, expression of immune checkpoints (CD276 and PVR), and more M1 macrophages but decreased B-cell abundance. …”

Evaluation of PCR amplification bias and PCR amplification efficiency. by Trang Thi Quynh Tran (20485595)

“…Standard curves obtained by plotting the CT values against the methylation level for the MSP primer set (rDNA Me) were linear, and that for the MIP primer set (Ref) remained constant throughout. (<b>B</b>) A serial dilution of human methylated DNA ranging from 5 pg to 1000 pg was bisulfite-treated and used as the template for qPCR. …”

Data Sheet 1_Global burden and trend of stroke attributable to metabolic risks among young adults (20–39 years old) from 1990 to 2021.docx by Qingguo Liu (9620123)

“…Objectives<p>Stroke is increasingly affecting young adults, with metabolic-risk factors playing a critical role in this trend. This study aims to assess the global burden and trends of stroke and its subtypes attributable to metabolic-risks in young adults from 1990 to 2021.…”

Image_1_Cell Adhesion Molecule Close Homolog of L1 (CHL1) Guides the Regrowth of Regenerating Motor Axons and Regulates Synaptic Coverage of Motor Neurons.TIF by Daria Guseva (191402)

“…Regarding the femoral nerve after injury, CHL1-deficient mice demonstrated preferential motor axon regrowth into the saphenous vs. quadriceps branch after nerve transection upstream of the nerve bifurcation by 8 weeks after transection, indicating decreased preferential motor re-innervation. Furthermore, in injured wild-type mice, enhanced CHL1 expression was observed in regenerating axons in the proximal nerve stump upstream of the bifurcation at days 1, 3, 5, 7 and 14, and in the distal stump at days 7 and 14 after injury, when compared to non-injured mice. …”

Image_1_Global burden and trends of pelvic organ prolapse associated with aging women: An observational trend study from 1990 to 2019.TIF by Bo Wang (86769)

“…</p>Conclusion<p>Over the past three decades, the incidence and DALY of POP have been decreasing from 1990 to 2019. However, POP remains a major health problem, especially among females in less developed countries. …”

Image_2_Both AMP-activated and cAMP-dependent protein kinase regulate the expression of heat shock protein 70-2 gene in Neopyropia yezoensis.tif by Zhenjie Sun (9723659)

“…Here, a full-length sequence of the hsp70-2 gene was cloned and its’ expression regulation was analyzed. …”

Crosstalk between the Ras/ERK pathway and DENV-induced AMPs. by Wen-Quan Liu (9323021)

“…C6/36 cells were transfected with pIB-Ras for 48h, the pIB-V5 vector was taken as the control. The total RNAs were extracted and the <i>AMPs</i> transcription was analyzed by qPCR. …”

Influenza Transmission in the Mother-Infant Dyad Leads to Severe Disease, Mammary Gland Infection, and Pathogenesis by Regulating Host Responses by Stéphane G. Paquette (5649400)

“…To understand the molecular mechanisms of mammary gland infection, we performed global transcript analysis which showed downregulation of milk production genes such as Prolactin and increased breast involution pathways indicated by a STAT5 to STAT3 signaling shift. Genes associated with cancer development were also significantly increased including JUN, FOS and M2 macrophage markers. …”

Image_1_Proper development of long-lived memory CD4 T cells requires HLA-DO function.tiff by Nianbin Song (8463012)

“…We explored the effects of DO on development of memory CD4 T cells and B cells utilizing two model antigens, H5N1-Flu Ag bearing DM-resistant, and OVA protein, which has a DM-sensitive immunodominant epitope and four mouse strains including two DO-deficient Tg mice. …”

Data_Sheet_1_Chemical and Structural Changes in Corn Stover After Ensiling: Influence on Bioconversion.csv by Nick J. Nagle (9241097)

“…We observed statistically significant decreases (p < 0.05) in the content of two major structural carbohydrates (glucan and xylan) of 5 and 8%, respectively, between the ensiled and non-ensiled materials. …”

Adolescents' Neural Processing of Risky Decisions: Effects of Sex and Behavioral Disinhibition by Thomas J. Crowley (167950)

“…</p><p>Methodology/Principal Findings</p><p>81 adolescents (Patients with substance and conduct problems, and comparison youths (Comparisons)), assessed in a 2 x 2 design (Patients:Comparisons x Male:Female) repeatedly decided between doing a cautious behavior that earned 1 cent, or a risky one that either won 5 or lost 10 cents. …”

Data_Sheet_1_FOXP3+ Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children.pdf by Tyyne Viisanen (6248525)

“…Moreover, the ratio of CCR6-CXCR3+ and CCR6+CXCR3- memory Tregs was altered and the frequency of proliferating Ki67-positive and IFN-γ producing memory Tregs was decreased in children with T1D. The frequency of CXCR5+FOXP3+ circulating follicular T regulatory cells was not altered in children with T1D. …”

Image_2_Proper development of long-lived memory CD4 T cells requires HLA-DO function.tiff by Nianbin Song (8463012)

“…We explored the effects of DO on development of memory CD4 T cells and B cells utilizing two model antigens, H5N1-Flu Ag bearing DM-resistant, and OVA protein, which has a DM-sensitive immunodominant epitope and four mouse strains including two DO-deficient Tg mice. …”

Image_3_The Microbiota Dynamics of Alfalfa Silage During Ensiling and After Air Exposure, and the Metabolomics After Air Exposure Are Affected by Lactobacillus casei and Cellulase... by Zongfu Hu (9692066)

“…Air exposure was associated with decreased lactic acid concentrations and increased yeast and mold counts in all silages. …”

DataSheet3_Gallic Acid Alleviates Neuropathic Pain Behaviors in Rats by Inhibiting P2X7 Receptor-Mediated NF-κB/STAT3 Signaling Pathway.docx by Runan Yang (6579239)

“…Gallic acid (3,4,5-trihydroxybenzoic acid) is a traditional Chinese medicine obtained from natural plants that exhibit anti-inflammatory, analgesic, and antitumor effects. …”

Cited4 is related to cardiogenic induction and maintenance of proliferation capacity of embryonic stem cell-derived cardiomyocytes during <i>in vitro</i> cardiogenesis by Junichiro Miake (4373017)

“…A cell proliferation assay, with 5-ethynyl-2′-deoxyuridine incorporation and Ki67 expression during the late phase of cardiogenesis, indicated that the number of troponin T-positive embryonic stem cell-direived cardiomyocytes with proliferative capacity was significantly greater in the overexpression group than in the control and knockdown groups. …”

Image_1_Effects of supplementation with lysophospholipids on performance, nutrient digestibility, and bacterial communities of beef cattle.pdf by Meimei Zhang (757618)

“…The Angus cattle were fed a total mixed ration that consisted of 25% roughage and 75% concentrate (dry matter [DM] basis). …”

Data_Sheet_1_Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke.docx by Cheng Luo (48047)

“…In permanent middle cerebral artery occlusion (pMCAo) model of rats, it suggested that SSS extraction in dose-dependent manner improved neurological function, cerebral blood flow (CBF), ¹⁸F-2-deoxy-glucose uptake and the density and diameter of alpha smooth muscle actin (α-SMA) positive vasculature in ipsilateral area, as well as decreased infarcted volume. Meanwhile, the metabolomics study in cerebrospinal fluid (CSF) was performed by using 5-(diisopropylamino)amylamine (DIAAA) derivatization-UHPLC-Q-TOF/MS approach. …”

Electrostatic versus Hydrogen Bonding Control of Selectivity in CO₂ Reduction by Iron Porphyrins by Soumili Ghosh (18445189)