The novel <i>carboxylesterase 1</i> variant c.662A>G may decrease the bioactivation of oseltamivir in humans by Jaeseong Oh (3947381)

“…A novel <i>CES1</i> c.662A>G single nucleotide polymorphism (SNP) was predicted to decrease CES1 enzymatic activity in an <i>in silico</i> analysis. …”

Brain and liver GCase activity are significantly decreased in heterozygous <i>GBA1</i> D409V KI mice, with varying differences in glucosphingolipid lipids in brain and liver. by Nicole K. Polinski (10947787)

“…(A-B) GCase levels as assessed by the CBE/4-MU method are significantly decreased in the het <i>GBA1</i> D409V KI mice at 5 months of age in both brain (A) and liver (B). …”

Microinjection of morphine in rat rostromedial tegmental nucleus (RMTg) decreased non-rapid eye movement (NREM) sleep in a dose-dependent manner. by Su-Rong Yang (467756)

Cell surface CHT levels are unchanged by altered PI3-Kinase signaling in non-depolarized cells. by Katherine J. Fishwick (768451)

Time course of central retinal thickness (CRT) in recurrence and non-recurrence groups. by Yasuyuki Sotani (20114144)

“…These values significantly decreased in the first postoperative year to 2.3 ± 2.6, 0.1 ± 0.3, 0.8 ± 1.6, 0, and 3.1 ± 2.8; in the second year to 2.1 ± 2.8, 0.4 ± 1.0, 0.0, 0.1 ± 0.3, and 2.6 ± 2.8; and in the third year to 2.0 ± 2.2, 0, 0.6 ± 1.7, 0.1 ± 0.3, and 2.8 ± 3.5 (Kruskal–Wallis test, p < 0.001; <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0332941#pone.0332941.g007" target="_blank">Fig 7</a>). …”

ND-75^KD flies have reduced mobility, seizures and decreased lifespan. by Lucy Granat (5570813)

GSPs decrease cell viability and induce cell death of HNSCC cells. by Ram Prasad (305524)

Inhibition of VEGF-A gene synthesis decreased ranibizumab and aflibercept mediated CCL2 CCL5, and CX3CL1 mRNA and protein levels in HCAECs. by Clare Arnott (2557705)

Glucagon receptor (GcgR) antagonism decrease α-cell proliferation. by Zhuo Liu (357070)

SF pretreatment inhibited the I/R induced decrease in the IRL thickness. by Hong Pan (8686)

Genetic information on 5 subjects carrying <i>NR5A1</i> mutations. by Jana Malikova (615672)

Subjects:

Silencing AXL in human colon cancer cells does not decrease proliferation. by Diana J. Uribe (2201695)

Delta Kmax¹ with non-accelerated and accelerated CXL² protocols. by Denise Wajnsztajn (3366902)

Subjects:

Decreased Rab10 localization in raft fractions following methamphetamine treatment. by Scott M. Vanderwerf (785324)

Inhibition of inflammatory signalling pathways decreases HSV-2 viral shedding. by Victor H. Ferreira (719813)

Inhibition of NEAT1 decreased the miR-204-5p expression and increased Six1 expression. by Lei Li (29537)

“…<p>(A) NEAT1 expression following siRNA transfection in BEAS-2B cells; (B-D) The expression of NEAT1, miR-204-5p, and Six1 after decreasing NEAT1 expression. * p <0.05, *** p < 0.001, and **** p <0.0001.…”

MET knockdown decreases EGFR activation and does not influence EGFR expression. by Karolin Ebert (7434713)

Time course of best-corrected visual acuity (BCVA) in recurrence and non-recurrence groups. by Yasuyuki Sotani (20114144)

“…In the non-recurrence group, CRT improved from 482.5 ± 112.8 to 294.7 ± 65.3, 302.0 ± 68.0, 284.7 ± 55.4, 285.3 ± 70.2, 265.2 ± 65.0, and 266.1 ± 78.2 μm at 1, 3, 6, 12, 24, and 36 months, respectively (Kruskal-Wallis test, p < 0.001; <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0332941#pone.0332941.g006" target="_blank">Fig 6</a>).…”

Pregnancy is associated with decreased polyubiquitinated protein levels, but not de-ubiqutination levels. by Andrea Iorga (298552)

TREM1 inhibition decreases HIV mediated inflammatory cytokine production. by Jinhee Hyun (6900683)