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VRK1 overexpression is seen in human breast cancer and is associated with decreased relapse-free survival.
Published 2018“…Data for cancer subtypes are shown in boxes numbered 1–11: 1: benign breast neoplasm (rank 6459, 1.4 fold-change, NS), 2: breast carcinoma (rank 833, 1.5 fold-change, p = 3.83x10<sup>-5</sup>), 3: breast phyllodes tumor (rank 512, 1.2 fold-change, p = 0.002), 4: ductal breast carcinoma in situ (rank 1969, 1.5 fold-change, p = 0.002), 5: invasive breast carcinoma (rank 1060, 1.6 fold-change, p = 1.28x10<sup>-5</sup>), 6: invasive ductal and invasive lobular breast carcinoma (rank 941, 1.5 fold-change, p = 6.76x10<sup>-22</sup>), 7: invasive ductal breast carcinoma (rank 613, 1.5-fold change, p = 2.71x10<sup>-71</sup>), 8: invasive lobular breast carcinoma (rank 947, 1.3 fold-change, p = 3.64x10<sup>-28</sup>), 9: medullary breast carcinoma (rank 400, 1.8 fold-change, p = 3.25x10<sup>-12</sup>), 10: mucinous breast carcinoma (rank 1932, 1.4 fold-change, p = 7.41x10<sup>-10</sup>) and 11: tubular breast carcinoma (rank 1253, 1.4 fold-change, p = 1.24x10<sup>-17</sup>). …”
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At E9.5 Actb<sup>−/−</sup> neural crest cells show a significant decrease of cadherin-11 expression.
Published 2014“…<p>(A) Quantification of N-cadherin intensities in Actb<sup>+/+</sup> and Actb<sup>−/−</sup> migratory cells adjacent to the neural tube at E8.5 and E9.5 (left graph, Y-axis: relative intensities) and colocalization of N-cadherin with p75 in migratory cells at E8.5 and E9.5 (right graph, Y-axis: colocalization index on a scale from 0 to 1). …”
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rVλ6Wil fibrils cause a decrease in cardiomyocytes MTT reduction without inducing cell death.
Published 2015“…(C) Cell number, quantified using crystal violet (black) did not decrease over 72 h of incubation with 1 μM rVλ6Wil fibrils despite a decrease in MMT reduction (grey; n = 3 samples per time point). …”
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<i>Cdkl5</i> -/Y mice show an increased freezing time and a decreased distance traveled during the pretone period in the altered context.
Published 2018“…<i>Cdkl5</i> -/Y mice show a significantly decreased distance traveled in response to the first footshock (p = 0.0158) compared with control mice. …”
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