Stereoselective Palladium-Catalyzed Base-Free Suzuki–Miyaura Cross-Coupling of Tetrasubstituted <i>gem</i>-Difluoroalkenes: An Experimental and Computational Study by Yanhui Wang (108090)

“…Density functional theory (DFT) calculations elucidated an intriguing reaction pathway favoring a formal [4 + 1] cycloaddition of Pd(0), followed by 1,5-sigmatropic fluoride migration, assisted by the chelation of the ester-substituent group to Pd center. …”

The expression of cell cycle and apoptosis regulators in induced and tolerant iDCs at 27h. by Kata Filkor (455814)

“…<p>Based on the SAGE-Seq data, we have chosen 2 cell cycle regulators, cyclin B2 (A) and cyclin D1 (B), and three apoptosis regulators, caspase-8 (C), FADD (D) and TGF-β (E) for the validation by QRT-PCR. …”

Altered Expression of Polycomb Group Genes in Glioblastoma Multiforme by Gang Li (34549)

“…We validated the aberrant expression of CBX6, CBX7, CBX8 and EZH2 in GBM cell lines by Western blotting and qRT-PCR, and further the aberrant expression of CBX6 in GBM tissue samples by immunohistochemical staining. …”

Image1_The integrated stress response protects against ER stress but is not required for altered translation and lifespan from dietary restriction in Caenorhabditis elegans.TIF by Zhengxin Ma (6309152)

“…We found that, while GCN2 phosphorylates eIF2α when nutrients are restricted, the ability to phosphorylate eIF2α is not required for changes in translation, nonsense-mediated decay, or lifespan associated with dietary restriction (DR). …”

DataSheet1_The integrated stress response protects against ER stress but is not required for altered translation and lifespan from dietary restriction in Caenorhabditis elegans.doc... by Zhengxin Ma (6309152)

“…We found that, while GCN2 phosphorylates eIF2α when nutrients are restricted, the ability to phosphorylate eIF2α is not required for changes in translation, nonsense-mediated decay, or lifespan associated with dietary restriction (DR). …”

Image4_The integrated stress response protects against ER stress but is not required for altered translation and lifespan from dietary restriction in Caenorhabditis elegans.TIF by Zhengxin Ma (6309152)

“…We found that, while GCN2 phosphorylates eIF2α when nutrients are restricted, the ability to phosphorylate eIF2α is not required for changes in translation, nonsense-mediated decay, or lifespan associated with dietary restriction (DR). …”

Image6_The integrated stress response protects against ER stress but is not required for altered translation and lifespan from dietary restriction in Caenorhabditis elegans.TIF by Zhengxin Ma (6309152)

“…We found that, while GCN2 phosphorylates eIF2α when nutrients are restricted, the ability to phosphorylate eIF2α is not required for changes in translation, nonsense-mediated decay, or lifespan associated with dietary restriction (DR). …”

Image3_The integrated stress response protects against ER stress but is not required for altered translation and lifespan from dietary restriction in Caenorhabditis elegans.TIF by Zhengxin Ma (6309152)

“…We found that, while GCN2 phosphorylates eIF2α when nutrients are restricted, the ability to phosphorylate eIF2α is not required for changes in translation, nonsense-mediated decay, or lifespan associated with dietary restriction (DR). …”

PolyQ expansion affects p53-dependent apoptotic function in cells and in zebrafish. by Hongmei Liu (129385)

“…<p>(A) HCT116 p53^+/+ and HCT116 p53^-/- cells transiently transfected with Flag-vector or normal Flag-ATX-3 or Flag-ATX-3-80Q were treated with CPT (1 μM) for 24 h and then analyzed by flow cytometry for apoptosis using Annexin-V/PI. …”

MUS81 causes DNA double-strand breaks upon Chk1 inhibition that result in cell death. by Josep V. Forment (119177)

“…Cells were transfected as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023517#pone-0023517-g002" target="_blank">Fig. 2</a>, and left untreated (NT) or treated with 50 nM AZD7762 (AZD), 2.5 µM aphidicolin (Aph), or a combination of both drugs (A+A) for 12 h. …”

Table_1_Racialized Pandemic: The Effect of Racial Attitudes on COVID-19 Conspiracy Theory Beliefs.DOCX by Christina E. Farhart (12267698)

“…<p>As national and international health agencies rushed to respond to the global spread of a novel coronavirus (SARS-CoV-2, commonly known as COVID-19), one challenge these organizations faced was the spread of misinformation and conspiracy theories about the virus. …”

Data_Sheet_1_Racialized Pandemic: The Effect of Racial Attitudes on COVID-19 Conspiracy Theory Beliefs.ZIP by Christina E. Farhart (12267698)

“…<p>As national and international health agencies rushed to respond to the global spread of a novel coronavirus (SARS-CoV-2, commonly known as COVID-19), one challenge these organizations faced was the spread of misinformation and conspiracy theories about the virus. …”

Modeling Retinal Degeneration Using Patient-Specific Induced Pluripotent Stem Cells by Zi-Bing Jin (230558)

“…It is well known that the disease is caused by rod photoreceptor degeneration; however, it remains incurable, due to the unavailability of disease-specific human photoreceptor cells for use in mechanistic studies and drug screening. We obtained fibroblast cells from five RP patients with distinct mutations in the <em>RP1</em>, <em>RP9</em>, <em>PRPH2</em> or <em>RHO</em> gene, and generated patient-specific induced pluripotent stem (iPS) cells by ectopic expression of four key reprogramming factors. …”

Evaluation of functional changes of the retina by electroretinography (ERG). by Po-Ting Yeh (845796)

“…<p>The ERG were performed on untreated rats (Control) or STZ-induced diabetic rats treated for 8 weeks with normal saline (Diabetes), 3 mg/kg AST (AST High), 0.6 mg/kg AST (AST Low), or 0.5 mg/kg lutein (Lutein). The relative b-wave ratio was significantly decreased in the Diabetes, AST Low and Lutein groups compared with the Control group. …”

Supplementary Material for: Exploring associations between cannabis prices, stores, and usage after recreational legalization by figshare admin karger (2628495)

“…Edibles use increased and was negatively associated with prices. Mean initial age of use increased; it was negatively associated with prices and positively with stores. …”

Drying kinetics of ‘gueroba’ (Syagrus oleracea) fruit pulp by Ana P. P. Jorge (10469029)

“…The most adequate model was selected through the coefficient of determination, mean relative and estimated errors, Chi-square test, AIC and BIC. …”

Infected cells in the neighbourhood of CD8+ T cells secreting non-lytic factors. by Nafisa-Katrin Seich al Basatena (201133)

“…<p>The mean fraction of wild type-infected cells neighbouring secreting CD8+ T cells was evaluated over time. …”

Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis-3 by Anna K Coussens (85627)

“…Absolute expression values represent molecules per ng cDNA. Mean expression ± SEM is shown.…”

Increased proportion of splenic pDCs in MCMV-infected WT male mice. by Stephanie Traub (189777)

“…<p>WT and TLR9^−/− male and female mice were left uninfected or infected i.p. with 1×10⁵ PFU of MCMV and spleens were harvested 36 h later. …”

Loss of parasympathetic cholinergic neurons innervating the liver. by Jiyeon Hwang (19747297)

“…Unpaired <i>t</i> test, **<i>p</i> < 0.01. (D) Images showing a lack of vAChT-positive nerve terminals in the liver parenchyma of ChAT^{Cre + AAVrg-FLEX-dtA} mice (right panel). …”