Simultaneous increase in canonical Wnt signaling and suppression of pAKT result in increased apoptosis of CC cells. by Michael Bordonaro (340595)

“…(B) The steady-state levels of transcriptionally active beta-catenin are not decreased in HCT-116 cells by combined treatment with a HDACi and MK2206. …”

data_sheet_1_Cord Blood CD8+ T Cells Have a Natural Propensity to Express IL-4 in a Fatty Acid Metabolism and Caspase Activation-Dependent Manner.csv by Yuxia Zhang (318750)

“…Here, we show that in the absence of IL-2 or IL-12, naïve cord blood CD8⁺ T cells have a natural propensity to differentiate into IL-4-producing non-classic T_C2 cells when they are activated alone, or in the presence of TGF-β and/or inflammatory cytokines. …”

DataSheet1_Identification and Verification of Potential Hub Genes in Amphetamine-Type Stimulant (ATS) and Opioid Dependence by Bioinformatic Analysis.doc by Wei Zhang (405)

“…However, the Nr4a2 mRNA levels increased in BV2 cells and decreased in the bioinformatic analysis.…”

data_sheet_3_Cord Blood CD8+ T Cells Have a Natural Propensity to Express IL-4 in a Fatty Acid Metabolism and Caspase Activation-Dependent Manner.PDF by Yuxia Zhang (318750)

“…Here, we show that in the absence of IL-2 or IL-12, naïve cord blood CD8⁺ T cells have a natural propensity to differentiate into IL-4-producing non-classic T_C2 cells when they are activated alone, or in the presence of TGF-β and/or inflammatory cytokines. …”

Relationship between the Thermally Induced Reorientations of Aromatic Solvate Molecules in Cu(hfac)₂–Nitroxide Breathing Crystals and the Character of the Magnetic Anoma... by Galina V. Romanenko (1584775)

“…When Cu(hfac)₂L·0.5C₆H₆ and Cu(hfac)₂L·0.5CH₃–C₆H₅ were cooled to 50 K, μ_eff decreased to ∼2.1–2.2 β. …”

The study area and the sampling plots. by Caiyun Guo (10303640)

“…The average annual ANPP required to support the ecosystem service of natural regeneration (ANPP_NR) in Inner Mongolia from 1987 to 2015 was 101.27 gCm^-2year^-1, revealing a similar spatial distribution with ANPP. (2) The total ecological carrying capacity of Inner Mongolian grassland was 78.52 million sheep unit hm^-2. …”

Hypoxia Promotes Uveal Melanoma Invasion through Enhanced Notch and MAPK Activation by Laura Asnaghi (622644)

“…Pharmacologic blockade of HIF-1α protein expression using digoxin dramatically suppressed cellular invasion both in normoxia and in hypoxia. We found that Notch pathway components, including Jag1-2 ligands, Hes1-Hey1 targets and the intracellular domain of Notch1, were increased in hypoxia, as well as the phosphorylation levels of Erk1-2 and Akt. …”

DataSheet_1_Serum uric acid is related to liver and kidney disease and 12-year mortality risk after myocardial infarction.docx by Luc Heerkens (16954658)

“…Multivariable prevalence ratios (PRs) were obtained for the association of NAFLD [fatty liver index (FLI), ≥77 (women) and ≥79 (men)] with CKD [estimated glomerular filtration rate (eGFR), <60 mL/min per 1.73 m²]. We calculated sensitivity and specificity of SUA to detect the (combined) presence and absence of NAFLD and CKD. …”

S1 File - by Caiyun Guo (10303640)

“…The average annual ANPP required to support the ecosystem service of natural regeneration (ANPP_NR) in Inner Mongolia from 1987 to 2015 was 101.27 gCm^-2year^-1, revealing a similar spatial distribution with ANPP. (2) The total ecological carrying capacity of Inner Mongolian grassland was 78.52 million sheep unit hm^-2. …”

Transcriptional Dysregulation of Upstream Signaling of IFN Pathway in Chronic HCV Type 4 Induced Liver Fibrosis by Marwa K. Ibrahim (446138)

“…The expression of TLR7 was decreased by 4 folds and MyD88 was increased by 3 folds in PBMCs of F2-F4 patients when compared to the healthy volunteers (p = 0.03 and 0.002, respectively). …”

Gene Transcription Changes in Asthmatic Chronic Rhinosinusitis with Nasal Polyps and Comparison to Those in Atopic Dermatitis by Douglas A. Plager (246260)

“…Additional transcription changes likely associated with Th2-like eosinophilic inflammation were prominent and included increased IL1RL1 (IL33 receptor) and EMR1&3 and decreased CRISP2&3. …”

Image_3_Nlrx1-Regulated Defense and Metabolic Responses to Aspergillus fumigatus Are Morphotype and Cell Type Specific.jpeg by Bridget Kastelberg (9033644)

“…Here, we present our subsequent efforts showcasing loss of Nlrx1 resulting in a decreased ability of host cells to process A. fumigatus conidia in a cell-type-specific manner by BEAS-2B airway epithelial cells, alveolar macrophages, bone marrow-derived macrophages, but not bone marrow-derived neutrophils. …”

Image_1_Nlrx1-Regulated Defense and Metabolic Responses to Aspergillus fumigatus Are Morphotype and Cell Type Specific.jpeg by Bridget Kastelberg (9033644)

“…Here, we present our subsequent efforts showcasing loss of Nlrx1 resulting in a decreased ability of host cells to process A. fumigatus conidia in a cell-type-specific manner by BEAS-2B airway epithelial cells, alveolar macrophages, bone marrow-derived macrophages, but not bone marrow-derived neutrophils. …”

InsulinR/IGF1-R signalling is dysregulated in the synaptosomal fraction of P7 <i>Bbs4</i>^{<i>−/−</i>} mice. by Naila Haq (7340180)

“…<p>(A) Phospho-RTK array reveals significant decrease in phosphorylation of insulin and IGF1 receptors in <i>Bbs4</i>^−/− (<i>N</i> = 2, mean ± SD). …”

Transcriptome and physiology analysis reveal key players of the shade-tolerant species <i>Panax notoginseng</i> in photosynthetic performance under both high and low light regimes by Jin-Yan Zhang (9037088)

“…</p> <p><b>Abbreviations:</b><i>A</i>_net, net assimilation rate; LCP, light compensation point; PQ, plastoquinone pool; LSP, light saturation point; PPFD, photosynthetic photon flux density; <i>C</i>_i, internal leaf CO₂ concentration; <i>A</i>_max, maximum net photosynthesis rate; CE, carboxylation efficiency; <i>J</i>_max, maximum electron transfer rate; <i>V</i>_cmax, maximum carboxylation efficiency; <i>R</i>_d, dark respiration rate; <i>F</i>_v/<i>F</i>_m, maximum quantum yield of photosystem II; Φ_PSII, PSII photochemical quantum yield; qP, photochemical quenching; <i>F</i>_v′/<i>F</i>_m′, photochemical efficiency of PSII in the light; NPQ, non-photochemical quenching; <i>Φ</i>_f.d, fluorescence quenching dissipation; <i>Φ</i>_NPQ, non-photochemical quenching dissipation; (V + A+Z), the xanthophyll cycle pigment pool; L, lutein; N, neoxanthin; β-Car, β-Carotene; SOD, superoxide dismutase; CAT, catalase; POD, peroxidase; APX, ascorbate peroxidase; MDHAR, monodehydroascorbate reductase; DHAR, dehydroascorbate reductase</p>…”

Longer crop cycle lengths could offset the negative effects of climate change on Brazilian maize by Tamires Teles de Souza (8141430)

“…The DSSAT/CERES-Maize model was calibrated with field data and then used to simulate current and six future climate scenarios, according to the AgMIP protocols. We selected three regional climate circulation models (GCMs) and two representative concentration pathways (RCPs) for the period of 2040-2069. …”

Interleukin-33 Increases Antibacterial Defense by Activation of Inducible Nitric Oxide Synthase in Skin by Changwei Li (525465)

“…The expression of IL-33 by macrophages was induced by staphylococcal peptidoglycan (PGN) and lipoteichoic acid (LTA) via activation of toll-like receptor 2(TLR2) –mitogen-activated protein kinase (MAPK)-AKT-signal transducer and activator of transcription 3(STAT3) signaling pathway as PGN and LTA failed to induce IL-33 in <i>Tlr2</i>-deficient peritoneal macrophages, and MAPK,AKT, STAT3 inhibitors significantly decreased PGN- or LTA-induced IL-33. …”

Image_1_Association Between Skeletal Muscle Mass and Severity of Steatosis and Fibrosis in Non-alcoholic Fatty Liver Disease.JPEG by Wen Guo (112664)

“…</p>Results<p>Of 3,602 finally enrolled individuals, 1,830 had NAFLD and 1,772 did not have NAFLD. SMI gradually decreased as the severity of hepatic steatosis increased (40.47 ± 3.94% vs. 39.89 ± 3.57% vs. 39.22 ± 3.46% vs. 37.81 ± 2.84%, P < 0.001). …”

Supplementary Material for: Cilostazol for Aneurysmal Subarachnoid Hemorrhage: An Updated Systematic Review and Meta-Analysis by Liu J. (3215370)

“…In 3 OSs which reported different doses of cilostazol (300 mg/day vs. 100–200 mg/day) for aSAH, the 300-mg/day cilostazol groups showed decreased delayed cerebral infarction (RR 0.27, 95% CI 0.09–0.81, <i>p</i> = 0.02) but no significant difference in shunt-dependent hydrocephalus (RR 0.92, 95% CI 0.33–2.60, <i>p</i> = 0.88) or functional outcomes (RR 1.14, 95% CI 0.74–1.75, <i>p</i> = 0.56) compared with the 100–200 mg/day cilostazol groups. …”

Generation and expression analysis of <i>SHOX</i>-transgenic mice. by Katja U. Beiser (571289)

“…The presence of only one signal per lane indicates a single integration site of the transgene. (D): Relative quantitative expression of <i>Col2a1</i> and <i>SHOXa</i> transcripts in limbs of wildtype and transgenic littermates (N = 5–8 per litter) at E12.5, E13.5 and E14.5. …”