Showing 21 - 40 results of 99,883 for search '(( 5 ((((nn decrease) OR (we decrease))) OR (a decrease)) ) OR ( 5 ht decrease ))', query time: 1.38s Refine Results
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    Pharmacological Mechanism of the Non-hallucinogenic 5‑HT<sub>2A</sub> Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

    Published 2022
    “…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G<sub>q</sub>, G<sub>11</sub>, and β-arrestin2) coupled to 5-HT<sub>2A</sub> receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”
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    Pharmacological Mechanism of the Non-hallucinogenic 5‑HT<sub>2A</sub> Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

    Published 2022
    “…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G<sub>q</sub>, G<sub>11</sub>, and β-arrestin2) coupled to 5-HT<sub>2A</sub> receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”
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    NaSal increased the excitability of 5-HTergic neurons, but decreased that of GABAergic neurons in the DRN of the ChR2 transgenic mouse. by Yan Jin (143500)

    Published 2015
    “…(D) Sample traces (left panel) and group data (right panel, paired Student’s <i>t</i>-test) showing that NaSal suppressed the firing of GABAergic neurons evoked by laser light (1 s, 5.5 mW, 473 nm). (E) Sample recordings from a GABAergic neuron showing that NaSal decreased voltage responses to a series of hyperpolarizing currents (-10 to -60 pA, -10 pA/step, duration: 500 ms). …”
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