Data_Sheet_1_GPR171 Agonist Reduces Chronic Neuropathic and Inflammatory Pain in Male, But Not Female Mice.docx by Akila Ram (6842501)

“…GPR171 is a promising therapeutic target that is widely expressed through the brain, including within the descending pain modulatory regions. Here, we explore the therapeutic potential of the GPR171 agonist, MS15203, in its ability to alleviate chronic pain in male and female mice using a once-daily systemic dose (10 mg/kg, i.p.) of MS15203 over the course of 5 days. …”

Data_Sheet_1_Adherence to COVID-19 preventive measures in Sub-Saharan Africa during the 1st year of the pandemic: Pooled analysis of the International Citizen Project on COVID-19 (... by Leonard Ngarka (6036032)

“…</p>Results<p>Responses from 26,678 respondents were analyzed (mean age: 31.0 ± 11.1 years; 54.1% males). Mean individual adherence score decreased from 3.80 ± 1.37 during Period 1, to 3.57 ± 1.43 during Period 2; p < 0.001. …”

Structure-Based Analysis of A19D, a Variant of Transthyretin Involved in Familial Amyloid Cardiomyopathy by Priscila Ferreira (498747)

“…As far as we know, this is the first description of a non-V30M mutation in Brazil. …”

CSF N-Glycan Profiles to Investigate Biomarkers in Brain Developmental Disorders: Application to Leukodystrophies Related to eIF2B Mutations by Anne Fogli (138515)

“…We found in control CSF that tri-antennary/bisecting and high mannose structures were highly represented in samples obtained between 1 to 5 years of age, whereas fucosylated, sialylated structures were predominant at later age. …”

Impact of modifications to periplasmic volume around optimal solution of ABC cell at nutrient concentration of 1 nM. by Noele Norris (10826554)

“…<p>To understand why the periplasm inflates as the nutrient concentration decreases to 1 nM, we plot the proportion of bound transport units (A) and effective half-saturation constant, K_M, (B) as we modify the periplasmic volume of the optimal solution for a nutrient concentration of 1 nM. …”

P2X6 subunit interacts with SF3A1 and Spectrin α2 in nuclear extracts from hippocampus of 8 month-old mice and alters splicing efficiency <i>in vitro</i>. by Juan Ignacio Díaz-Hernández (721171)

“…As expected TPI I firefly luciferase-dependent luminescence decreases and TPI II firefly luciferase-dependent luminescence increases when splicing is impaired (mean±s.e.m., n = 5 independent experiments, * P<0.05 unpaired Student’s t-test). …”

The extreme N-terminus of TDP-43 is required to repress <i>UNC13A</i> cryptic exon splicing. by Yuka Koike (2249959)

“…Blot provided in Supporting information (<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002028#pbio.3002028.s013" target="_blank">S1 Raw images</a>). qRT-PCR (right) analysis shows significantly decreased TDP-43 binding to <i>UNC13A</i> RNA only in the cells expressing GFP-TDP-43_5FL compared with the cells expressing GFP-TDP-43_WT. …”

Separate effects of NASH and WD on the microbiome. by James K. Carter (9937022)

“…Fecal samples were sequenced from 3–10 mice per condition (mean = 5), except NASH week 12 where n = 2. P values are encoded as * = p < 0.05, ** = p < 0.01, and *** = p < 0.001.…”

Dose-response study of DEX on IP to FD4 and GR expression in the small intestine and the colon. by Nabila Moussaoui (525508)

“…Data are expressed as the mean±SEM (n = 3–10 pups per group).</p>…”

Effect of Alpinia zerumbet essential oil on the shelf life of tambaqui fillets during short-term refrigerator storage by Ana Karolinne Anastacio de SOUSA (6673673)

“…The treatments were A. zerumbet essential oil at 0.75% v v-1 (AEO 0.75%), A. zerumbet essential oil at 1.5% v v-1 (AEO 1.5%) and a control (no essential oil). …”

Dynamic cerebral autoregulation is impaired in Veterans with Gulf War Illness: A case-control study by Michael J. Falvo (4437265)

“…Dynamic autoregulation was significantly lower in GWI+ than GWI- both for autoregulatory index (2.99±1.5 vs 4.50±1.5, <i>p</i> = 0.017). In addition, we observed greater decreases in CBF velocity both at the nadir after standing (-18.5±6.0 vs -9.8±4.9%, <i>p</i> = 0.001) and during steady state standing (-5.7±7.1 vs -1.8±3.2%, <i>p</i> = 0.042). …”

DNA epitope vaccine improves acquisition and retention of spatial memory in immune mice. by Nina Movsesyan (86328)

“…<p>A) The escape latency to reach the platform was significantly decreased in the groups of non-transgenic (n = 6) and 3xTg-AD immune mice (n = 9) versus age-matched groups of MDC-irrelevant control (n = 5) and non-vaccinated control 3xTg-AD mice (n = 5). …”

Targeting Anticancer Drug Delivery to Pancreatic Cancer Cells Using a Fucose-Bound Nanoparticle Approach by Makoto Yoshida (151742)

“…Excess L-fucose decreased the efficiency of Cy5.5 introduction by L-fucose-bound liposomes, suggesting L-fucose-receptor-mediated delivery. …”

Can handling a weapon make soldiers more unstable? by L. Eduardo Cofré Lizama (14095293)

“…This study determined the effects of weapon handling and speed on gait stability in seventeen soldiers walking on a treadmill with and without a replica weapon at self-selected (SS), 3.5 km·h⁻¹, 5.5 km·h⁻¹, and 6.5 km·h⁻¹ while carrying a 23-kg load. …”

Investigating sperm selection in Y-shredding strains. by Matteo Vitale (13130647)

“…We found no significant differences in the ratio of Y-bearing and nSC sperm between the testes and spermathecae in this strain. n Te = 5, n Sp = 5. …”

COWPEA LEAF AREA, BIOMASS PRODUCTION AND PRODUCTIVITY UNDER DIFFERENT WATER REGIMES IN CASTANHAL, PARÁ, BRAZIL by PAULO JORGE DE OLIVEIRA PONTE DE SOUZA (6140720)

“…Growth and productivity data were submitted to analysis of variance with two variation factors (water regime and experimental year) at 5% probability. Student's t -test at 5% probability was used in the means of the stomatal conductance data, since this was monitored only in 2012. …”

Differential gene expression in bovine endometrial epithelial cells treated with IFNT2 or IFNTc1. by Kazuya Kusama (768185)

“…<p>(A) Venn diagram shows the number of gene with 1.5-fold changes among Control (Ctrl), IFNT2, and IFNTc1 treatment groups, and right table lists increased or decreased genes in IFNT2 vs. …”

Paclitaxel inhibits proliferation, induces EMT, and up-regulates miR-375 expression simultaneously in cervical cancer cells. by Yuanming Shen (645855)

“…The representative cells with morphological changes were labeled (<b>b</b>) Immunoblotting measured the expression of Ecadherin and other EMT related proteins (vimentin, Ncadherin, and fibronectin) in cervical cancer cells (SiHa and CaSki) under different amounts (0, 5, 10, 20 nM) of paclitaxel treatment. The expression of Ecadherin protein was decreased and the expressions of vimentin, Ncadherin, and fibronectin protein were increased in cells treated with paclitaxel for 72 hours in a dose-responsive manner. …”

Local treatment of toxoplasmic retinochoroiditis with intravitreal clindamycin and dexamethasone by Yuslay Fernández Zamora (5763242)

“…Fourteen eyes (87.5%) improved ≥ 2 ETDRS lines of BCVA, of two or more Early Treatment Diabetic Retinopathy Study lines, BCVA remained stable in two eyes (12.5%), and no patient had decreased BCVA at the end of the follow-up period. …”

RIPK3 overexpression inhibits tumor growth. by Yang Xu (178421)

“…The data represent the mean percentage ± SD of viable cells compared to parental cells. …”