Discovery of Novel [1,2,4]Triazolo[1,5‑<i>a</i>]pyrimidine Derivatives as Novel Potent S‑Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer by Kaizhao Hu (15670612)

“…Pharmacological inhibition of Skp2 has exhibited promising antitumor activity. Herein, we present the design and optimization of a series of [1,2,4]triazolo[1,5-<i>a</i>]pyrimidine-based small molecules targeting Skp2. …”

Contact angle between solid and liquid. by Xinhui Luo (11880086)

“…We prepared the blends of these five surfactants, each with a mass fraction of 0.5 wt%, in a 1:1 ratio, resulting in 10 blended solutions. …”

Diagram of the experimental equipment. by Xinhui Luo (11880086)

“…We prepared the blends of these five surfactants, each with a mass fraction of 0.5 wt%, in a 1:1 ratio, resulting in 10 blended solutions. …”

Sedimentation experimental device. by Xinhui Luo (11880086)

“…We prepared the blends of these five surfactants, each with a mass fraction of 0.5 wt%, in a 1:1 ratio, resulting in 10 blended solutions. …”

The wetting feature of compound solutions. by Xinhui Luo (11880086)

“…We prepared the blends of these five surfactants, each with a mass fraction of 0.5 wt%, in a 1:1 ratio, resulting in 10 blended solutions. …”

Absorption peaks of groups. by Xinhui Luo (11880086)

“…We prepared the blends of these five surfactants, each with a mass fraction of 0.5 wt%, in a 1:1 ratio, resulting in 10 blended solutions. …”

Infrared spectrogram of lignite. by Xinhui Luo (11880086)

“…We prepared the blends of these five surfactants, each with a mass fraction of 0.5 wt%, in a 1:1 ratio, resulting in 10 blended solutions. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Claudin V is decreased following infection with Mtb. by Amanda S. Latham (12093638)

“…<p>Immunofluorescent staining of guinea pig brain tissue for DAPI (blue) and claudin V (cyan) in vessels was performed. Representative images of the frontal cortex (A–D), cerebral nuclei (F–I), brain stem (K–N), thalamus (P–S), and hippocampus (U–X) 15 days post-infection are shown. …”

C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion by Yunwei Shi (10116568)

“…Here, we determined whether C5aR1 signaling was essential to the post-ischemic inflammation and brain injury and whether it is a valid target for therapeutic blockade by using soluble receptor antagonist PMX53 in the early stage after I/R injury. …”

C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion by Yunwei Shi (10116568)

“…Here, we determined whether C5aR1 signaling was essential to the post-ischemic inflammation and brain injury and whether it is a valid target for therapeutic blockade by using soluble receptor antagonist PMX53 in the early stage after I/R injury. …”

C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion by Yunwei Shi (10116568)

“…Here, we determined whether C5aR1 signaling was essential to the post-ischemic inflammation and brain injury and whether it is a valid target for therapeutic blockade by using soluble receptor antagonist PMX53 in the early stage after I/R injury. …”

C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion by Yunwei Shi (10116568)

“…Here, we determined whether C5aR1 signaling was essential to the post-ischemic inflammation and brain injury and whether it is a valid target for therapeutic blockade by using soluble receptor antagonist PMX53 in the early stage after I/R injury. …”

C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion by Yunwei Shi (10116568)

“…Here, we determined whether C5aR1 signaling was essential to the post-ischemic inflammation and brain injury and whether it is a valid target for therapeutic blockade by using soluble receptor antagonist PMX53 in the early stage after I/R injury. …”

Detection of cytosine methylation by enzymatic digestion and Southern blot and confirmation of bisulfite sequencing results by PCR and Sanger sequencing. by Mareike Möller (5548745)

datasheet1_Allopregnanolone Decreases Evoked Dopamine Release Differently in Rats by Sex and Estrous Stage.docx by Ana Paula S. Dornellas (9983996)

“…As allopregnanolone is a potent positive allosteric modulator of GABA_A receptors, and GABA_A receptors can regulate dopamine release, we hypothesized that allopregnanolone would reduce phasic fluctuations in mesolimbic dopamine release that are important in learning and reward processing. …”

Related to Fig 5A. by Rani Moran (3315630)

“…<p>The findings for vegetables were similar to the findings for animal reported in the main text: we found a positive effect for the high-vegetable reward (b = 0.24, t(1736) = 4.33, p = 2e-5) and non-significant effects for the low (b = -0.11, t(1736) = -1.42, p = .156) and unrelated (b = 0.08, t(1736) = 1.88, p = .06) vegetable-reward. …”

SARS-CoV-2 genome sequencing metrics. by Ludy R. Carmola (20978107)

“…We investigated viral and host factors, including vaccination status, that were associated with SARS-CoV-2 disease severity in a setting with low vaccination rates. …”

SARS-CoV-2 variants by vaccination status. by Ludy R. Carmola (20978107)

“…We investigated viral and host factors, including vaccination status, that were associated with SARS-CoV-2 disease severity in a setting with low vaccination rates. …”