Deciphering Nonbioavailable Substructures Improves the Bioavailability of Antidepressants by Serotonin Transporter by Zhi-Zheng Wang (6056033)

“…A machine learning model was developed to identify nonbioavailable substructures based on their molecular properties and shows the accuracy of 83.5%. …”

Deciphering Nonbioavailable Substructures Improves the Bioavailability of Antidepressants by Serotonin Transporter by Zhi-Zheng Wang (6056033)

“…A machine learning model was developed to identify nonbioavailable substructures based on their molecular properties and shows the accuracy of 83.5%. …”

Deciphering Nonbioavailable Substructures Improves the Bioavailability of Antidepressants by Serotonin Transporter by Zhi-Zheng Wang (6056033)

“…A machine learning model was developed to identify nonbioavailable substructures based on their molecular properties and shows the accuracy of 83.5%. …”

Deciphering Nonbioavailable Substructures Improves the Bioavailability of Antidepressants by Serotonin Transporter by Zhi-Zheng Wang (6056033)

“…A machine learning model was developed to identify nonbioavailable substructures based on their molecular properties and shows the accuracy of 83.5%. …”

A nonsense mutation in <i>anmK</i> contributes to decreased growth of AC811 in Arabidopsis leaves. by Megan R. O’Malley (7485323)

Expression of <i>uvrC</i> is decreased in AC811 but not in Δ<i>gacA</i>-1. by Megan R. O’Malley (7485323)

Mean scores and 95% CIs according to SARS-CoV-2 infection status and work-related determinants. by A. H. Ayesha Lavell (16734002)

Data_Sheet_1_Pulmonary inflammation decreases with ultra-protective ventilation in experimental ARDS under VV-ECMO: a positron emission tomography study.docx by Guillaume Deniel (17990323)

“…However, whether these strategies reduce lung inflammation more effectively than protective ventilation (PV) remains unclear. We aimed to demonstrate that a UPV strategy decreases acute lung inflammation in comparison with PV in an experimental swine model of ARDS.…”

Table_1_Domesticating Vigna stipulacea: Chromosome-Level genome assembly reveals VsPSAT1 as a candidate gene decreasing hard-seededness.xlsx by Yu Takahashi (381135)

“…While doing so, we produced a V. stipulacea whole-genome assembly of 441 Mbp in 11 chromosomes and 30,963 annotated protein-coding sequences. …”

Expanding Three-Coordinate Gold(I) Anticancer Agent Chemical Space by Charles E. Greif (21728091)

“…We report the synthesis and characterization of 14 complexes of the type (Au(R)[N̂N])⁺, where R = tunable biaryldialkyl phosphine ligands and [N̂N] = bidentate phenanthroline derivatives as anticancer agents. …”

Table_2_A novel anxiety-associated SNP identified in LYNX2 (LYPD1) is associated with decreased protein binding to nicotinic acetylcholine receptors.xlsx by Kristin R. Anderson (5478734)

Image_1_A novel anxiety-associated SNP identified in LYNX2 (LYPD1) is associated with decreased protein binding to nicotinic acetylcholine receptors.jpg by Kristin R. Anderson (5478734)

Table_1_A novel anxiety-associated SNP identified in LYNX2 (LYPD1) is associated with decreased protein binding to nicotinic acetylcholine receptors.pdf by Kristin R. Anderson (5478734)

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor by Anat Levit Kaplan (12126567)

“…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …”

DataSheet_1_Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A.pdf by Hai-xin Huang (15774248)

“…SADS-CoV nsp5 targets and cleaves mRNA-decapping enzyme 1a (DCP1A) via its protease activity to inhibit the IRF3 and NF-κB signaling pathways in order to decrease IFN-β and inflammatory cytokine production. …”

CD5-2 decreases established CCM lesions in the hindbrain of <i>Ccm2</i>^<i>ECKO</i> mice and lesions in the retina of <i>Ccm2</i>^<i>ECKO</i> mice. by Jia Li (160557)

mGluR5 receptor decreased glycinergic currents. by Zi-Yang Zhang (4988555)

“…<p>(<b>A–B</b>) Bath perfusion of DHPG for 3 min reduced GlyR-IPSCs (<b>A</b>; 70.2 ± 4.2% of baseline at 15–20 min post-DHPG, <i>t</i>[16] = 6.707, <i>p</i> < 0.001, paired Student <i>t</i> test), but not GABA_A-receptor–mediated IPSCs (<b>B</b>; 102.9 ± 3.3% of baseline at 15–20 min post-DHPG, <i>t</i>[5] = 0.347, <i>p</i> = 0.743) in spinal slices of mice. …”

Decreased expression of V-ATPase upon the siRNA transfection. by Manisha Naskar (2613763)

Decreased expression of ATG5 upon the siRNA transfection. by Manisha Naskar (2613763)