Neuroprotective effects of dexmedetomidine against hyperoxia-induced injury in the developing rat brain by Stefanie Endesfelder (121559)

“…Furthermore, regulators of neuronal plasticity (Nrp1, Nrg1, Syp, and Sema3a/f) were also drastically decreased. A single administration of dexmedetomidine prior to oxygen exposure resulted in a significant up-regulation of expression-profiles compared to hyperoxia. …”

Streptavidin-Response Curves for Biotinylated Magnetic Nanoparticles Suspended in 1x Phosphate Buffered Saline, 1 Micro Molar Bovine Serum Albumin, and 1 Micro Molar Monomeric Stre... by Gabrielle Moss (19742920)

“…<p dir="ltr">The streptavidin-biotin bond has a k_off of ~10^-6 1/s, while the SavPhire monomeric streptavidin-biotin bond has a k_off of ~10^-5 1/s. …”

Data from: Too Materialistic to get Married and have Children? by P. LI Norman (8657433)

“…Path analyses indicated that materialistic values led to more negative attitudes toward marriage, which led to more negative attitudes toward children, which in turn led to a decreased number of children desired. Results across two studies highlight, at the individual level, the tradeoff between materialistic values and attitudes toward marriage and procreation and suggest that a consideration of psychological variables such as materialistic values may allow for a better understanding of larger-scale socioeconomic issues including low fertility rates among developed countries. …”

Nutrient concentrations in the cherry tomato under application management of the nutrient solution with brackish water by Alexandre Nascimento dos Santos (10479021)

“…The experimental design was of completely randomised blocks in a 6 x 2 x 2 factorial scheme, with six levels of salinity for the nutrient solution (3.01, 4.51, 5.94, 7.34, 8.71 and 10.40 dS m-1), two periods of plant exposure to salinity (51 and 6 days), and two irrigation frequencies (one irrigation per day and one irrigation every two days). …”

Computational modeling of the bimodal distribution of RPs and altered parameters of the resting ion channels on the distribution of RPs. by Yuqin Yang (579353)

“…We computed the instantaneous conductances of Kir and K_D by Boltzmann equations, and the membrane potentials by the Hodgkin-Horowitz equation: <math><mrow><msub><mi>G</mi><mrow><mi>K</mi><mi>i</mi><mi>r</mi></mrow></msub><mo>=</mo><msub><mi>G</mi><mrow>max<mo>,</mo><mi>K</mi><mi>i</mi><mi>r</mi></mrow></msub><mo>/</mo><mrow><mo>(</mo><mrow><mn>1</mn><mo>+</mo>exp<mrow><mo>(</mo><mrow><mrow><mo>(</mo><mrow><msub><mi>V</mi><mi>m</mi></msub><mo>−</mo><msub><mi>V</mi><mrow><mn>0.5</mn></mrow></msub></mrow><mo>)</mo></mrow><mo>/</mo><mi>k</mi></mrow><mo>)</mo></mrow></mrow><mo>)</mo></mrow></mrow></math>; <math><mrow><msub><mi>G</mi><mrow><mi>K</mi><mi>D</mi></mrow></msub><mo>=</mo><msub><mi>G</mi><mrow>max<mo>,</mo><mi>K</mi><mi>D</mi></mrow></msub><mo>−</mo><msub><mi>G</mi><mrow>max<mo>,</mo><mi>K</mi><mi>D</mi></mrow></msub><mo>/</mo><mrow><mo>(</mo><mrow><mn>1</mn><mo>+</mo>exp<mrow><mo>(</mo><mrow><mrow><mo>(</mo><mrow><msub><mi>V</mi><mi>m</mi></msub><mo>−</mo><msub><mi>V</mi><mrow><mn>0.5</mn></mrow></msub></mrow><mo>)</mo></mrow><mo>/</mo><mi>k</mi></mrow><mo>)</mo></mrow></mrow><mo>)</mo></mrow></mrow></math>; <math><mrow><msub><mi>V</mi>m</msub><mo>=</mo><mrow><mo>(</mo><mrow><msub><mi>E</mi><mi>K</mi></msub><mo>*</mo><mrow><mo>(</mo><mrow><msub><mi>G</mi><mrow><mi>K</mi><mi>i</mi><mi>r</mi></mrow></msub><mo>+</mo><msub><mi>G</mi><mrow><mi>K</mi><mi>N</mi><mi>V</mi></mrow></msub><mo>+</mo><msub><mi>G</mi><mrow><mi>K</mi><mi>D</mi></mrow></msub></mrow><mo>)</mo></mrow><mo>+</mo><msub><mi>E</mi><mi>L</mi></msub><mo>*</mo><msub><mi>G</mi><mi>L</mi></msub></mrow><mo>)</mo></mrow><mo>/</mo><mrow><mo>(</mo><mrow><msub><mi>G</mi><mrow><mi>K</mi><mi>i</mi><mi>r</mi></mrow></msub><mo>+</mo><msub><mi>G</mi><mrow><mi>K</mi><mi>N</mi><mi>V</mi></mrow></msub><mo>+</mo><msub><mi>G</mi><mrow><mi>K</mi><mi>D</mi></mrow></msub><mo>+</mo><msub><mi>G</mi><mi>L</mi></msub></mrow><mo>)</mo></mrow></mrow></math>; Stable RPs were determined by programmed computation with MatLab software using up to 200 iterations after the initial parameters input (See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0125266#pone.0125266.s001" target="_blank">S1 Dataset</a> for <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0125266#pone.0125266.g008" target="_blank">Fig 8<b><i>A—</i></b> 8<b><i>I</i></b></a>). …”

Crosstalk between JNKs and Smad2/3 signaling pathway in response to BMP9-induced osteogenic differentiation of hPDLSCs. by Pei Wang (102036)

“…<p>(<b>A</b>) Western blotting results showed that treatment with the JNK inhibitor SP600125 at different concentrations (5, 10, or 15 mM) has a negative effect on BMP9-induced phosphorylation of Samd2/3, in a dose-dependent manner. …”

Electronic configuration of the polypeptide backbone versus complexity of tertiary structure and order of oligomerization in soluble and integral membrane proteins. by Andrzej Stanisław Cieplak (2717653)

“…Δ<i>FP</i>_{<i>i-1→i+1</i>} plots, cf. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0180905#pone.0180905.g005" target="_blank">Fig 5</a>, may characterize the relationship between distribution of backbone density and organization of globular structure. …”

Expression of RIO kinases is associated with EGFR and Akt activity in GBM cells. by Renee D. Read (268044)

“…(F) Extracts from <i>PTEN^−/−; Ink4a/arf^−/−</i> astrocytes transduced with empty vector (left) or ΔEGFR (right), or grown with .5% serum and treated with gefitinib for 24 hrs (far right). …”

Evaluation of Bite Force and Masticatory Performance: Complete Denture vs Mandibular Overdenture Users by Anna Paula da Rosa Possebon (10439900)

“…IMO users presented significantly higher BF (p=0.01) without presenting a dominant side (p=0.38), and also performed significantly better for the following MP parameters: MPX50 values decreased by 27.25% in IMO users (p=0.01), MPB decreased by 48.38% (p=0.01), and ME 5.6 decreased by 53.25% (p=0.02), while ME2.8 increased by 151.57% (p=0.01). …”

Altering let-7b regulated ET-1 and TGFBR1 expression in PAECs. by Lijuan Guo (404771)

“…(<b>A</b>) Endogenous let-7b was decreased to a level about 55% by antagonist lentivirus and was increased to about 2 fold by mimics. …”

DataSheet_1_PRKCI Mediates Radiosensitivity via the Hedgehog/GLI1 Pathway in Cervical Cancer.docx by Zhuna Wu (12879656)

“…We aimed to elucidate the molecular mechanisms underlying radiosensitivity to identify methods to improve the overall 5-year survival rate. The atypical protein kinase C iota (aPKCι) gene PRKCI exhibits tumor-specific copy number amplification (CNA) in CC. …”

Table_3_PRKCI Mediates Radiosensitivity via the Hedgehog/GLI1 Pathway in Cervical Cancer.doc by Zhuna Wu (12879656)

“…We aimed to elucidate the molecular mechanisms underlying radiosensitivity to identify methods to improve the overall 5-year survival rate. The atypical protein kinase C iota (aPKCι) gene PRKCI exhibits tumor-specific copy number amplification (CNA) in CC. …”

Table_4_PRKCI Mediates Radiosensitivity via the Hedgehog/GLI1 Pathway in Cervical Cancer.doc by Zhuna Wu (12879656)

“…We aimed to elucidate the molecular mechanisms underlying radiosensitivity to identify methods to improve the overall 5-year survival rate. The atypical protein kinase C iota (aPKCι) gene PRKCI exhibits tumor-specific copy number amplification (CNA) in CC. …”

Table_1_PRKCI Mediates Radiosensitivity via the Hedgehog/GLI1 Pathway in Cervical Cancer.doc by Zhuna Wu (12879656)

“…We aimed to elucidate the molecular mechanisms underlying radiosensitivity to identify methods to improve the overall 5-year survival rate. The atypical protein kinase C iota (aPKCι) gene PRKCI exhibits tumor-specific copy number amplification (CNA) in CC. …”

Proteomics investigation of the changes in serum proteins after high- and low-flux hemodialysis by Shuai Han (545347)

“…Among the increased and decreased proteins, the isoelectric point (pI) values mainly ranged from 5 to 7, and the molecular weights (Mws) were mostly smaller than 30 kDa. …”

Image_3_PRKCI Mediates Radiosensitivity via the Hedgehog/GLI1 Pathway in Cervical Cancer.tif by Zhuna Wu (12879656)

“…We aimed to elucidate the molecular mechanisms underlying radiosensitivity to identify methods to improve the overall 5-year survival rate. The atypical protein kinase C iota (aPKCι) gene PRKCI exhibits tumor-specific copy number amplification (CNA) in CC. …”

Table_2_PRKCI Mediates Radiosensitivity via the Hedgehog/GLI1 Pathway in Cervical Cancer.doc by Zhuna Wu (12879656)

“…We aimed to elucidate the molecular mechanisms underlying radiosensitivity to identify methods to improve the overall 5-year survival rate. The atypical protein kinase C iota (aPKCι) gene PRKCI exhibits tumor-specific copy number amplification (CNA) in CC. …”

The CPP impaired YB-1s transcriptional activity against HER-2 and EGFR. by Jennifer H. Law (242119)

“…The transcription factor responsible for binding was YB-1 because introducing 1 µg of YB-1 antibody (lanes 4) caused a super-shift in the binding product. YB-1 bound with high affinity in the presence of acetic acid control (lane 5) and 25 µM scrambled peptide (lane 6), whereas incubation with 25 µM of the CPP blocked binding and cause a super-shift (lane 7).…”

Image_7_PRKCI Mediates Radiosensitivity via the Hedgehog/GLI1 Pathway in Cervical Cancer.tif by Zhuna Wu (12879656)

“…We aimed to elucidate the molecular mechanisms underlying radiosensitivity to identify methods to improve the overall 5-year survival rate. The atypical protein kinase C iota (aPKCι) gene PRKCI exhibits tumor-specific copy number amplification (CNA) in CC. …”

Image_6_PRKCI Mediates Radiosensitivity via the Hedgehog/GLI1 Pathway in Cervical Cancer.tif by Zhuna Wu (12879656)

“…We aimed to elucidate the molecular mechanisms underlying radiosensitivity to identify methods to improve the overall 5-year survival rate. The atypical protein kinase C iota (aPKCι) gene PRKCI exhibits tumor-specific copy number amplification (CNA) in CC. …”