Effects of siRNA on RET/PTC3 Junction Oncogene in Papillary Thyroid Carcinoma: From Molecular and Cellular Studies to Preclinical Investigations by Hafiz Muhammad Ali (554920)

“…Our aim is to demonstrate <i>in vitro</i> and <i>in vivo</i> molecular and cellular effects of siRNA on <i>RET/PTC3</i> knockdown for therapeutic application.First, we established a novel cell line stably expressing <i>RET/PTC3</i> junction oncogene, named RP3 which was found tumorigenic in nude mice compared to NIH/3T3 mouse fibroblasts. …”

Data_Sheet_1_Cardioprotecive Properties of Known Agents in Rat Ischemia-Reperfusion Model Under Clinically Relevant Conditions: Only the NAD Precursor Nicotinamide Riboside Reduces... by Yang Xiao (146335)

“…., opiates, benzodiazepines, P2Y₁₂ antagonist, propofol) need to be identified in preclinical models.</p><p>Methods: Here, we examined the efficacy of promising cardioprotective compounds [fingolimod (Fingo), empagliflozin (Empa), melatonin (Mela) and nicotinamide riboside (NR)] administered i.v. as bolus before start ischemia. …”

Insights into the mechanism regulating the differential expression of the P28-OMP outer membrane proteins in obligatory intracellular pathogen <i>Ehrlichia chaffeensis</i> by Nan Duan (4837896)

Presentation 1_Telehealth coaching in older adults, behavior change, and impacts of the COVID-19 pandemic: analyses from The Brain Health Champion Study.pdf by Brittany McFeeley (21104825)

“…Study 1.0 participants indicated a decrease in cognitive activities since the start of COVID-19 restrictions, whereas those in Study 2.0 reported an increase in cognitive activities.…”

Effect of the measurement of the work of breathing on the respiratory outcome of preterms by Benjamin Dudoignon (11051311)

Tie2 mRNA and protein expression in control and <i>Tie2</i> knockout mice. by Peter J. Zwiers (7510744)

Schematic of experimental paradigms. by Shiva Farashahi (5018381)

“…A central yellow bar represented the probability of reward (between 0.5 and 1.0), while the peripheral arc indicated the amount of reward. …”

Study on the properties of oil-water interface after the interaction between ionized water and naphthenic acid by Qin Guowei (22155073)

“…The results show that after the action, the interfacial tension of oil and water continues to decrease, and 1/3 ionized water (salinity diluted to 1/3 of the prepared ionized water, 1253 ppm) decreases to a maximum of 50.89%, while 1/5 ionized water (752 ppm) only decreases 14.40%; the thickness of the oil-water interface film decreases with the salinity of ionized water, but the decrease increases after 1/3 ionized water. …”

Zebrafish TMEM33 attenuates MAVS-induced cellular antiviral function. by Long-Feng Lu (6528632)

“…<p>(A and B) Overexpression of TMEM33 restores MAVS-mediated decrease of viral titer. …”

Categorising trajectories and individual item changes of the North Star Ambulatory Assessment in patients with Duchenne muscular dystrophy by Francesco Muntoni (228210)

“…Using the NorthStar Clinical Network database, 395 patients with >1 NSAA assessment were identified. We utilised latent class trajectory analysis of longitudinal NSAA scores, which produced evidence for at least four clusters of boys sharing similar trajectories versus age in decreasing order of clinical severity: 25% of the boys were in cluster 1 (NSAA falling to ≤ 5 at age ~10y), 35% were in cluster 2 (NSAA ≤ 5 ~12y), 21% in were cluster 3 (NSAA≤ 5 ~14y), and 19% in cluster 4 (NSAA > 5 up to 15y). …”

Proteomics Profiling of Cerebrum Mitochondria, Myelin Sheath and Synaptosome Revealed Mitochondrial Damage and Synaptic Impairments in Association with 3 × Tg‐AD Mice Model by Liming Shen (8533629)

Empagliflozin Reduces Liver Fat in Diabetic and Nondiabetic Subjects by Siham Abdelgani (17756772)

Repression of <i>hmsT</i> by Fur. by Fengjun Sun (113206)

“…</b> The radioactively labeled promoter-proximal DNA fragment of <i>hmsT</i> was incubated with increasing amounts of purified His-Fur protein, and then subjected to 4% (w/v) polyacrylamide gel electrophoresis; with the increasing amounts of His-Fur, the band of free target DNA disappeared, and a retarded DNA band with decreased mobility turned up, which presumably represented the protein-DNA complex. …”

The effect of mutation rate variation. by Thomas Mailund (51584)

“…<p>The figure shows the effect on parameter estimation when the mutation rate is varied along the genome alignment. We split the alignment into segments geometrically distributed with mean length 500 bp and 2 kbp, and the mutation rate is then scaled by a random value chosen uniformly in the range 0.75 to 1.25 or 0.5 to 1.5. …”

Table_1_Influence of Combined Transcranial Direct Current Stimulation and Motor Training on Corticospinal Excitability in Children With Unilateral Cerebral Palsy.DOCX by Samuel T. Nemanich (6630293)

“…Contralesional MEP amplitude decreased as hypothesized in five of five participants receiving active tDCS immediately after and 6 months after the intervention, however no statistically significant differences between intervention groups were noted for MEP amplitude [mean difference = −323.9 μV, 95% CI = (−989, 341), p = 0.34] or CSP duration [mean difference = 3.9 ms, 95% CI = (−7.7, 15.5), p = 0.51]. …”

Table_2_Influence of Combined Transcranial Direct Current Stimulation and Motor Training on Corticospinal Excitability in Children With Unilateral Cerebral Palsy.DOCX by Samuel T. Nemanich (6630293)

“…Contralesional MEP amplitude decreased as hypothesized in five of five participants receiving active tDCS immediately after and 6 months after the intervention, however no statistically significant differences between intervention groups were noted for MEP amplitude [mean difference = −323.9 μV, 95% CI = (−989, 341), p = 0.34] or CSP duration [mean difference = 3.9 ms, 95% CI = (−7.7, 15.5), p = 0.51]. …”

Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol by Peitao Wu (8811071)

MPA gap analysis results based upon alternate choices of datasets. by Casey C. O'Hara (3997529)

“…Scenario 2 updates the results using AquaMaps version 08/2015, showing very small changes despite the inclusion of an additional 5,545 species. Scenario 3, still using 2015 AquaMaps data, drops the presence threshold to zero, showing an expected decrease in gap species, but also a decrease in species with 5% or greater protected range. …”

Example simulation of the 2D Ising model. by Manfred Füllsack (4691716)

“…<p>Simulation of the 2D-Ising model with an external magnetic field H taken as critical parameter (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0259177#pone.0259177.e001" target="_blank">Eq 1</a>), on the x-axis, first increasing (H = -0.5 to 0.6, left half) and then decreasing (H = 0.6 to -0.5, right half). …”

Pace Versus Prediction: Is the Experience of the Runner Associated With Marathon Success? by Dan Gordon (2110918)

“…Significant differences observed between PT and FT for all EXP groups apart from EXP-5 (P= 0.0001). EXP-0 showed significant difference across all split times apart from 35-40 km (P=0.0001) with a decrease in normalised speed from 5km (109.0 ±7.6) –40km (89.9 ±7.4%). …”