Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility by Ricardo Martinez (5665279)

“…Using an isogenic cellular model system, PF-7006 is shown to be selectively cytotoxic to Rb1-deficient cells relative to Rb1-competent cells (also a measure of kinase selectivity). Human bone marrow cells pretreated with palbociclib have decreased PF-7006-dependent apoptosis relative to cells without palbociclib pretreatment. …”

Table_1_Clinical Character of CASPR2 Autoimmune Encephalitis: A Multiple Center Retrospective Study.docx by Xiaoxiao Qin (9247765)

“…The concentration of proteins in CSF increased in 10 patients (ranging from 480 to 1,337.6 mg/dl), decreased in seven patients (ranging from 23.2 to 130.5 mg/dl) and remained at a normal range in the other eight patients (ranging from 150 to 450 mg/dl). …”

Supplementary Material for: Intranasal Administration of Extracellular Vesicles Mitigates Apoptosis in a Mouse Model of Neonatal Hypoxic-Ischemic Brain Injury by Lawson A. (12293438)

Supplementary Material for: Changes in Plasma Amyloid and Tau in a Longitudinal Study of Normal Aging, Mild Cognitive Impairment, and Alzheimer’s Disease by Chen T.-B. (4273591)

Supplementary Figure 1, Supplementary Figure 2, Supplementary Figure 3 from Intratumoral Injection of <i>Clostridium novyi</i>-NT Spores in Patients with Treatment-refractory Advan... by Filip Janku (15019245)

“…Supplementary Figure 2. Tumor antigen specific T-cell responses after C. novyi injection. …”

<i>Drosophila</i> peroxisomal gene networks. by Michael F. Wangler (544124)

“…(B) Co-regulated genes within the top 1000 genes in each cluster include multiple pathways in carbohydrate metabolism including glycogen metaboliwsm and glycolysis The metabolomics results from <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006825#pgen.1006825.g006" target="_blank">Fig 6</a> with green indicating a consistent decrease in metabolite levels in the <i>pex</i> mutants, are overlaid with the genes responsible for the relevant steps in metabolism and their representation within the gene cluster (C1 = Cluster 1, C2 = Cluster 2 etc.).…”

Pre-existing CD4+ T cell immunity to non-cognate core epitopes drives the rapid production of isotype-switched, higher avidity antibodies against target antigens. by Thomas Hills (351639)

“…If Welch’s correction is used for unequal variances, the significance of difference between the anti-OVA_323-339 IgG1 and IgG2c responses reduces to * (p < 0.05). (f) The concentration of the chaotropic agent sodium thiocyanate required to decrease the anti-CSP ELISA signal by 50% was determined in serum from mice (n = 4) pre-vaccinated with either PBS or OVA_323-339 in TMG four weeks after vaccination with CSP(OVA_323-339) liposomes and compared with unpaired, two-tailed t tests.…”

OCA inhibits the colony formation capacity of iCCA cells. by S. Di Matteo (6260417)

“…The number of colonies decreases in the presence of 0.5 μM OCA. Photographs (magnification 4x) show representative colonies formed by mixed and mucinous iCCA cells, with evident decreased dimension induced by 0.5 μM OCA. b) The number of colonies was normalised to control (0 μM OCA) considered equal to 100. …”

Datasheet1_Cardiotoxicity of CPX-351 in children and adolescents with relapsed AML: a Children's Oncology Group report.docx by Kasey J. Leger (18827263)

“…Cancer therapy related cardiac dysfunction (CTRCD) was defined as a decline in LVEF of ≥10%–<50%.</p>Results<p>Twenty-five of 38 heavily anthracycline pre-treated (median 348 mg/m² daunorubicin equivalents) subjects enrolled on AAML1421 were included in the cardiac analyses. …”

The effect of adjuvant oral application of honey in the management of postoperative pain after tonsillectomy in adults: A pilot study by Katharina Geißler (2634643)

“…</p><p>Results</p><p>Average pain in activity in the control group was greater than 4 (NRS 4.4 ± 2.4) during the first five postoperative days, with a renewed increase in pain intensity on the fifth day (4.3 ± 2.5). …”

Table 1_Efficacy and safety of dietary polyphenol supplements for COPD: a systematic review and meta-analysis.docx by Dongsheng Wu (2469307)

“…Meta-analysis was performed using RevMan 5.3 software.</p>Results<p>The randomized controlled trials (RCTs) included in this review examined dietary supplementation with eight polyphenols—curcumin, resveratrol, anthocyanins, quercetin, salidroside, dietary beetroot juice, pomegranate juice, and adjunctive oral AKL1 treatment—across a total of 894 participants. …”

The effect of 3-month finasteride challenge on biomarkers for predicting cancer outcome on biopsy: Results of a randomized trial by Javier Hernandez (242120)

“…<div><p>Background</p><p>Finasteride, a 5-alpha reductase inhibitor may have effects on biomarkers such as prostate-specific antigen (PSA) that could be leveraged to improve screening.…”

Image_1_Bacteroides fragilis Prevents Clostridium difficile Infection in a Mouse Model by Restoring Gut Barrier and Microbiome Regulation.JPEG by Huimin Deng (1844299)

“…Notably, the abundance of Bacteroides fragilis was reported to be significantly decreased in CDAD patients. This study aimed to clarify the prophylactic effects of B. fragilis strain ZY-312 in a mouse model of C. difficile infection (CDI). …”

Image_3_Bacteroides fragilis Prevents Clostridium difficile Infection in a Mouse Model by Restoring Gut Barrier and Microbiome Regulation.jpeg by Huimin Deng (1844299)

“…Notably, the abundance of Bacteroides fragilis was reported to be significantly decreased in CDAD patients. This study aimed to clarify the prophylactic effects of B. fragilis strain ZY-312 in a mouse model of C. difficile infection (CDI). …”

Image_4_Bacteroides fragilis Prevents Clostridium difficile Infection in a Mouse Model by Restoring Gut Barrier and Microbiome Regulation.JPEG by Huimin Deng (1844299)

“…Notably, the abundance of Bacteroides fragilis was reported to be significantly decreased in CDAD patients. This study aimed to clarify the prophylactic effects of B. fragilis strain ZY-312 in a mouse model of C. difficile infection (CDI). …”

Image_1_Bacteroides fragilis Prevents Clostridium difficile Infection in a Mouse Model by Restoring Gut Barrier and Microbiome Regulation.JPEG by Huimin Deng (1844299)

“…Notably, the abundance of Bacteroides fragilis was reported to be significantly decreased in CDAD patients. This study aimed to clarify the prophylactic effects of B. fragilis strain ZY-312 in a mouse model of C. difficile infection (CDI). …”

Image_4_Bacteroides fragilis Prevents Clostridium difficile Infection in a Mouse Model by Restoring Gut Barrier and Microbiome Regulation.JPEG by Huimin Deng (1844299)

“…Notably, the abundance of Bacteroides fragilis was reported to be significantly decreased in CDAD patients. This study aimed to clarify the prophylactic effects of B. fragilis strain ZY-312 in a mouse model of C. difficile infection (CDI). …”

A mouse model of wildfire smoke-induced health effects: sex differences in acute and sustained effects of inhalation exposures by Mary Buford (6983480)

“…<b><i>Methods</i>:</b> Mice were exposed to inhaled WS utilizing locally harvested wood to recapitulate community exposures. WS was generated at a rate resulting in a 5 mg/m³ PM_2.5 exposure for five days. …”

Data_Sheet_1_Peripheral blood monocytes as a therapeutic target for marrow stromal cells in stroke patients.PDF by Nikunj Satani (3605696)

“…In trans-well co-cultures of MSCs and monocytes isolated from stroke patients, we found statistically significant increased levels of IL-4 and MCP-1, and decreased levels of IL-6, IL-1β, and TNF-α. …”

DataSheet1_The Role of Lamins in the Nucleoplasmic Reticulum, a Pleiomorphic Organelle That Enhances Nucleo-Cytoplasmic Interplay.PDF by Merel Stiekema (12879917)

“…Furthermore, viruses can induce both type I and II NR. In laminopathies, the amount of A-type lamins throughout the nucleus is generally decreased or the organization of lamins or lamin-associated proteins is disturbed. …”