Pharmacological Mechanism of the Non-hallucinogenic 5‑HT_2A Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

“…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G_q, G₁₁, and β-arrestin2) coupled to 5-HT_2A receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”

Inhibition of VEGF-A gene synthesis decreased ranibizumab and aflibercept mediated CCL2 CCL5, and CX3CL1 mRNA and protein levels in HCAECs. by Clare Arnott (2557705)

<i>jun-1</i> mutants are highly susceptible to both Bt strains, while <i>elt-2</i> silencing decreased survival on Bt679 but increased survival on Bt247. by Alejandra Zárate-Potes (9415842)

(A) CaMKII inhibition by KN-93 or AIP, or calmodulin inhibition by W-7 decreases O₂ consumption in SANC suspension (n = 5 for each drug), (B) AIP decreases mitochondrial flavoprotein fluorescence in single SANC (representative example), indicating a net reduction of flavoprotein pool. by Yael Yaniv (162548)

The VPS C846G mutation decreases the stability of VPS11 protein. by Jinglan Zhang (401545)

Decreased levels of vitamin D3 and supplementation with 1,25-dihydroxyvitamin D3-glycoside on performance, carcass yield and bone quality in broilers by Osvanira dos Santos Alves (5555027)

“…Seven-d-old male chickens Cobb500® were distributed in a randomized design with six treatments: a control diet with inclusion of vitamin D3 in the premix, without supplementation of 1,25(OH)2D3-glycoside, and five diets with decreased levels of vitamin D3 (100%, 75%, 50%, 25% and 0% about the control) plus the addition of 1,25(OH)2D3-glycoside, 50g ton-1 of diet. …”

Dynamics of nocodazole washout upon Mad2 overexpression. by Alma Beatrix Stier (20903134)

Aspirin-Triggered Resolvin D1 Attenuated IL-1β-induced Cytokine/Chemokine Secretion. by Ruan Cox Jr. (789575)

Optogenetic Recruitment of Dorsal Raphe Serotonergic Neurons Acutely Decreases Mechanosensory Responsivity in Behaving Mice by Guillaume P. Dugué (620333)

“…<i>In vivo</i>, the photoactivation of dorsal raphe serotonergic neurons gave rise to a prominent light-evoked field response that displayed some sensitivity to a 5-HT1A agonist, consistent with autoreceptor inhibition of raphe neurons. …”

Increased AHP Amplitude and decreased AP firing in the presence of kainic acid is dependent on the GluR5 subunit. by Barbara Gisabella (330774)

“…<p><b>A</b>, Bath application of UBP296 does not change AP duration and RMP (<b>B</b>) of fast-spiking interneurons from PICRO-treated rats compared to experimental conditions with no drug. <b>C</b>, <b>D</b>, UBP296 application is associated with an increase of AHP and decrease of AP firing rate in SO of CA2/3 fast-spiking interneurons from PICRO-treated rats. …”

Schematic of the D2 model (standard non-competitive model). by Hidetoshi Urakubo (578508)

Subjects:

Decreased biomechanical stability of bones from <i>Col1a1-Krm2</i> transgenic mice. by Jochen Schulze (365258)

“…(C) µCT scanning of the femora showing reduced cortical thickness and impaired mineralization (scale bars, 500 µm). (D) Cortical thickness (C.Th.) and bone mineral density (vBMD) are decreased in <i>Col1a1-Krm2</i> transgenic mice compared to wildtype littermates. …”

GF mice have decreased levels of innate and adaptive immune effectors at the ocular surface. by Abirami Kugadas (3131940)

“…<p>A. Significantly decreased levels of complement proteins at the ocular surface in GF mice compared to SPF mice. …”

Decreased hair cell number of PLL neuromast in <i>PrP2</i>-MO. by Sylvaine Huc-Brandt (667335)

DA-dip detectable region appears between two increasing boundaries in the space of D2R and RGS. by Hidetoshi Urakubo (578508)

Subjects:

Functional consequences of absence of glycosylation in class II strains. by Joseph Gault (427444)

Excel spreadsheet containing, in separate sheets, the underlying numerical data and statistical analysis graph for Figs 1A and 1B, 2C and 2D, 3B, 3C and 3F, 4C, 5B and 5C, 6D, 7C,... by Xiongnan Chen (13307178)

Ang II decreases brain hemorrhages, delays experimental cerebral malaria and increases survival of mice. by Julio Gallego-Delgado (796586)

Transient neonatal olfactory deprivation causes a persistent decrease in the addition of CR+ PGCs. A by Yasuko Kato (122938)

“…*<i>P</i><0.05. <b>D</b>: Experimental procedure. Mice undergoing 2-week hemilateral naris occlusion from P5 were injected with BrdU just before naris reopening by nasal-plug removal at P19. …”

Pseudocolor plots of the local membrane potential illustrating spiral-wave dynamics in a mural slice of our 2D simulation domain with a random distribution of myocytes and fibrobla... by Rupamanjari Majumder (128411)