Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design by Gergő Dargó (3138048)

“…The knowledge on human serum albumin (HSA) binding is of utmost importance as it affects pharmacokinetic behavior and bioavailability of drugs. In this article, we report a novel method to screen for ionizable molecules with high HSA binding affinity based on p<i>K</i>_a shifts using UV-pH titration. …”

Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design by Gergő Dargó (3138048)

“…The knowledge on human serum albumin (HSA) binding is of utmost importance as it affects pharmacokinetic behavior and bioavailability of drugs. In this article, we report a novel method to screen for ionizable molecules with high HSA binding affinity based on p<i>K</i>_a shifts using UV-pH titration. …”

Image_5_The Dis1/Stu2/XMAP215 Family Gene FgStu2 Is Involved in Vegetative Growth, Morphology, Sexual and Asexual Reproduction, Pathogenicity and DON Production of Fusarium gramine... by Yuanye Zhu (2621176)

Data_Sheet_1_Cannabinoid Receptor 1 Blockade Attenuates Obesity and Adipose Tissue Type 1 Inflammation Through miR-30e-5p Regulation of Delta-Like-4 in Macrophages and Consequently... by Kathryn Miranda (6688094)

“…Consistent with a decrease in DLL4-Notch signaling, fat storage and pro-inflammatory cytokine/chemokine expression was reduced following AM251 treatment. …”

Table_1_The Extent of Human Apolipoprotein A-I Lipidation Strongly Affects the β-Amyloid Efflux Across the Blood-Brain Barrier in vitro.docx by Roberta Dal Magro (5474120)

“…The results showed that discoidal HDL displayed a superior capability to promote Aβ efflux in vitro (9 × 10^-5 cm/min), when compared to apoA-I in other lipidation states. …”

Data_Sheet_1_Short Practical Regimen of Acupuncture for Melasma: A Prospective Cohort Study in a Tertiary Hospital in Thailand.PDF by Thanan Supasiri (11644450)

“…At 1 week after five sessions of acupuncture in Group A, the mean MI decreased by 28.7 (95% CI −38.5 to −18.8, p < 0.001), whereas the median MASI decreased by 3.4 (95% CI −6.9 to −1.2, p < 0.001) points. …”

A Porphodimethene Chemical Inhibitor of Uroporphyrinogen Decarboxylase by Kenneth W. Yip (257594)

“…Because there is no known chemical UROD inhibitor suitable for use in translational studies, we aimed to design, synthesize, and characterize such a compound. …”

Declining seroprevalence of hepatitis A in Vojvodina, Serbia by Snežana Medić (4911829)

“…<div><p>To assess the current hepatitis A virus (HAV) endemicity in the Autonomous Province of Vojvodina, Serbia, we examined the seroprevalence and susceptibility profiles of the general population. …”

Flowchart for the categorization of prospective change in self-reported measures. by Marc Dupuis (5832347)

Ozonation as a pre-treatment of landfill leachate by Leticia Tamara Hoffmann (10423900)

Short matches define the limits of a deletion by Amos Tanay (46980)

Performing different kinds of physical exercise differentially attenuates the genetic effects on obesity measures: Evidence from 18,424 Taiwan Biobank participants by Wan-Yu Lin (91498)

“…The significance level throughout this work was set at 0.05/550 = 9.1x10^-5 because a total of 550 tests were performed. …”

Demographic and ocular features. by Mingxi Shao (10066570)

“…The XGBoost or KNN model using TAS alone achieved the highest AUC (0.74) in five-fold cross-validation.</p><p>Conclusion</p><p>The decrease in TAS levels and the increase in H₂O₂ and MDA levels are found to be correlated with PCG, and the results indicate that oxidative stress plays a part in congenital glaucoma onset.…”

Machine learning model to diagnose PCG. by Mingxi Shao (10066570)

“…The XGBoost or KNN model using TAS alone achieved the highest AUC (0.74) in five-fold cross-validation.</p><p>Conclusion</p><p>The decrease in TAS levels and the increase in H₂O₂ and MDA levels are found to be correlated with PCG, and the results indicate that oxidative stress plays a part in congenital glaucoma onset.…”

ROC curves of TAS + SOD + MDA to diagnose PCG. by Mingxi Shao (10066570)

“…The XGBoost or KNN model using TAS alone achieved the highest AUC (0.74) in five-fold cross-validation.</p><p>Conclusion</p><p>The decrease in TAS levels and the increase in H₂O₂ and MDA levels are found to be correlated with PCG, and the results indicate that oxidative stress plays a part in congenital glaucoma onset.…”

Photomanipulation of the CeA social and food cells. by Karolina Rojek-Sito (13197192)

“…The control group had the social interaction after a brief, 10-minute separation (Ctrl) <b>(B)</b> Representative image of c-Fos expression in the CeA in the SI group (lower magnification of the image shown in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002343#pbio.3002343.g001" target="_blank">Fig 1C</a>). …”

S1 Data - by Xiaochun Zhao (448387)

Overall survival of metastatic prostate cancer patients starting docetaxel treatment. by Weixin Wu (714474)

Representative case showing topographic change after epiretinal membrane (ERM) removal. by Seung Min Lee (1644409)

Reproducibility of the CO rebreathing technique with a lower CO dose and a shorter rebreathing duration at sea level and at 2320 m of altitude by Laura Oberholzer (9401512)

“…Its clinical application is often hindered due to the consequent rise in carboxyhemoglobin (%HbCO) and the concern of CO toxicity. We tested the reproducibility of the CO rebreathing with a CO dose of 0.5 mL/kg body mass (CO_0.5) compared to 1.5 mL/kg (CO_1.5) and when shortening the CO rebreathing protocol. …”