Huntingtons Disease Mice Infected with <i>Toxoplasma gondii</i> Demonstrate Early Kynurenine Pathway Activation, Altered CD8+ T-Cell Responses, and Premature Mortality by David W. Donley (3111198)

“…Activation of the kynurenine pathway of tryptophan degradation is implicated in the pathogenesis of HD. Indoleamine-2,3-dioxygenase (IDO) catalyzes the oxidation of tryptophan to kynurenine, the first step in this pathway. …”

p21 is regulated by AR and required for cellular senescence. by Yelena Mirochnik (179447)

“…Tubulin was used as a loading control (A). Note the decrease in Rb phosphorylation and p21 increase in DHT-treated cells at every time point. …”

Early blockade of CB1 and/or CB2 receptors reduces the density of serotonergic fibres below the lesion site. by Angel Arevalo-Martin (298990)

“…(E) Quantification of the area occupied by serotonin shows a significant decrease in AM630- and AM281/AM630-treated rats and a strong trend to decrease in AM281-treated rats, that is close to statistical significance (p = 0.06). …”

Data_Sheet_1_Fire Responses to the 2010 and 2015/2016 Amazonian Droughts.pdf by Celso H. L. Silva Junior (6702308)

Data_Sheet_1_Fire Responses to the 2010 and 2015/2016 Amazonian Droughts.pdf by Celso H. L. Silva Junior (6702308)

Neuropathy-related mutations alter the membrane binding properties of the human myelin protein P0 cytoplasmic tail by Arne Raasakka (180418)

Evolutionary Conservation and Diversification of Puf RNA Binding Proteins and Their mRNA Targets by Gregory J. Hogan (160970)

“…Focusing on Puf proteins and their targets across 80 fungi, we constructed a parsimonious model for their evolutionary history. …”

Keratinocyte differentiation factor 1 enhances cervical cancer cell viability and migration by activating the PI3K/AKT pathway by Chao Chen (195669)

DataSheet1_Characteristics of adverse reactions of three anti-glioma drugs in WHO-VigiAccess.ZIP by Huadong Ke (19937268)

“…The analysis revealed that the ten most frequently reported AEs included bone marrow suppression, myalgia, leukopenia, thrombocytopenia, nausea, vomiting, death, rhabdomyolysis, disease progression, and a decrease in neutrophil count. The five most common categories of AEs related to anti-glioma drugs were blood and lymphatic system diseases (20,233 cases, 15.2%), general disorders and administration site conditions (26,973 cases, 20.3%), gastrointestinal dysfunction (22,061 cases, 16.7%), necessitating further investigations (18,285 cases, 13.8%), and musculoskeletal and connective tissue diseases (30,695 cases, 23.1%). …”

Long Covid Risk by Ahmed Shaheen (18344985)

Uniformity and comparability: an analysis of the relevance for the Brazilian capital market by Emanuelle Frasson Guimarães (12830659)

Neurotransmitter content. by Charmaine Y. Pietersen (37545)

DataSheet_1_Two new coastal time-series of seawater carbonate system variables in the NW Mediterranean Sea: rates and mechanisms controlling pH changes.docx by Maribel I. García-Ibáñez (17938661)

“…Once accounted for the neutralizing effect of TA increase, the rapid sea surface warming plays a larger role in the observed pH decreases (43% at EOS and 62% at BBMO) than the DIC increase (36% at EOS and 33% at BBMO).…”

SNEV forms homo-oligomeres that are dependent on the amino acids 56–92 of SNEV by Johannes Grillari (13055)

“…This amount is comparable to the one without addition of peptides (GST–SNEV) as well as to the amount of GST–SNEV added to the beads (Input). () Increasing amounts of the Prp19-1 peptide (0, 5 and 10 nM) decrease the amount of precipitated GST–SNEV () Additional confirmation of SNEV self interaction derives from FRET analysis. …”

Image_2_Clostridium butyricum Supplement Can Ameliorate the Intestinal Barrier Roles in Broiler Chickens Experimentally Infected With Clostridium perfringens.TIF by Xiao Xu (112147)

“…Among normal flora in the broiler intestinal region, Clostridium butyricum has been identified as a probiotic agent that reduces the susceptibility of broilers to C. perfringens. …”

Image_1_Clostridium butyricum Supplement Can Ameliorate the Intestinal Barrier Roles in Broiler Chickens Experimentally Infected With Clostridium perfringens.TIF by Xiao Xu (112147)

“…Among normal flora in the broiler intestinal region, Clostridium butyricum has been identified as a probiotic agent that reduces the susceptibility of broilers to C. perfringens. …”

Table1_Lifetime evaluation of left ventricular structure and function in male ApoE null mice after gamma and space-type radiation exposure.DOCX by Agnieszka Brojakowska (11084123)

“…This was also observed later in 100 cGy γ-IR mice at 28 days. At later stages, a significant decrease in LV systolic function was observed in the 400 cGy γ-IR mice. …”

Image_3_Clostridium butyricum Supplement Can Ameliorate the Intestinal Barrier Roles in Broiler Chickens Experimentally Infected With Clostridium perfringens.TIF by Xiao Xu (112147)

“…Among normal flora in the broiler intestinal region, Clostridium butyricum has been identified as a probiotic agent that reduces the susceptibility of broilers to C. perfringens. …”

C1 shows similar results on macrophages as for microglia and does not interfere with cell activity, proliferation, and cell death are not affected in non-stimulated conditions. by Philipp Jordan (9364068)

“…The LPS induced release of IL1β and IL6 was not changed in the presence of C1 or DMSO. DMSO showed a significant effect on the release of TNFα in the concentrations 1.25x10^-5 v/v (p < 0.0001) and 12.5x10^-5 v/v (p = 0.005). 2.5 μM C1 decreased the release of TNFα significantly to 91% compared to the positive control (p = 0.0313). *** p<0.001 ** p<0.01 * p<0.05 comparing to stimulated control, ### p<0.001 ## p<0.01 ## p<0.05 comparing to DMSO (1way ANOVA followed by Bonferroni’s post-hoc test).…”

Epigenome-wide association studies of occupational exposure to benzene and formaldehyde by Rachael V. Phillips (6880574)

“…In the benzene EWAS, we found genome-wide significant alterations, i.e., FWER-controlled <i>P</i>-values <0.05, in the mean and variance of methylation at 22 and 318 CpG sites, respectively, and in mean methylation of a large genomic region. …”