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Drugs which cluster on the 'anxiolytic' group decrease 5-HT turnover in the brain.
Published 2014“…Points represent means and error bars represent standard errors. A negative correlation is found between the decrease in serotonin turnover and the increase in time on white produced by a drug (r<sup>2</sup> = 0.5688, p = 0.0073).…”
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442
Intravitreal ALF-186 decreased the IRI-induced capsase-3 and NF-κB mRNA expression and affected the heat-shock response differently.
Published 2017“…<p><b>(A)</b> Fold induction of caspase-3 mRNA expression after PBS, ALF-186, or iALF injection after IRI compared to GAPDH in relation to the corresponding non-ischemic contralateral retina analyzed by RT-PCR (n = 6; mean±SD; *** = p<0.001; *** = p<0.001). …”
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Reproductive transition paralleled a significant decrease in LDH5 and LDH1 expressions in nonTg hippocampus.
Published 2013“…<p>A. NonTg hippocampus demonstrated a an age-related decrease in LDH5 expression from 6 to 15 months of age, which was significant between 6 and 9, 9 and 12 months of age. …”
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Validation of a New Scoring Scale for Behavioral Assessment of L‑Dopa-Induced Dyskinesia in the Rat: A New Tool for Early Decision-Making in Drug Development
Published 2017“…The rating scale was sensitive enough to highlight a dose-dependent amantadine-mediated decrease (about 2.2-fold) in LID score. …”