LRRTM3 Interacts with APP and BACE1 and Has Variants Associating with Late-Onset Alzheimer’s Disease (LOAD) by Sarah Lincoln (160061)

“…Brain mRNA levels of <i>LRRTM3</i> showed significant correlations with <i>BACE1</i>, <i>CTNNA3</i> and <i>APP</i> in ∼400 humans, but not in <i>LRRTM3</i> knock-out mice. Finally, we assessed 69 single nucleotide polymorphisms (SNPs) within and flanking <i>LRRTM3</i> in 1,567 LOADs and 2,082 controls and identified 8 SNPs within a linkage disequilibrium block encompassing 5′UTR-Intron 1 of <i>LRRTM3</i> that formed multilocus genotypes (MLG) with suggestive global association with LOAD risk (p = 0.06), and significant individual MLGs. …”

HYS-32-Induced Microtubule Catastrophes in Rat Astrocytes Involves the PI3K-GSK3beta Signaling Pathway by Chi-Ting Chiu (734340)

“…In this study, we further investigated the signaling mechanism and EB1, a microtubule-associated end binding protein, involved in HYS-32-induced microtubule catastrophes. …”

Image_1_EPC infusion ameliorates acute graft-versus-host disease-related endothelial injury after allogeneic bone marrow transplantation.jpg by Weiwei Wang (105069)

“…Interestingly, infusion of EPC reduced the clinical and pathological score of aGVHD, decreased infiltration of mononuclear cells, improved survival as well as upregulated VE-cadherin and downregulated MHC-II molecule.…”

Data_Sheet_1_Double-Sine-Wave Quadri-Pulse Theta Burst Stimulation of Precentral Motor Hand Representation Induces Bidirectional Changes in Corticomotor Excitability.docx by Nikolai H. Jung (3560903)

“…DSW PA-qTBS at 666 Hz caused a stable increase in PA-MEP, whereas AP-qTBS at 666 Hz induced a transient decrease in AP-MEP. …”

Image_2_EPC infusion ameliorates acute graft-versus-host disease-related endothelial injury after allogeneic bone marrow transplantation.jpg by Weiwei Wang (105069)

“…Interestingly, infusion of EPC reduced the clinical and pathological score of aGVHD, decreased infiltration of mononuclear cells, improved survival as well as upregulated VE-cadherin and downregulated MHC-II molecule.…”

Mitochondrial OXPHOS activity of ATZ-treated rat skeletal muscle mitochondria. by Soo Lim (172772)

“…<p>Rats on a regular diet were treated with or without ATZ for 5 months. …”

Diagrammatic illustrations to show the hypothetical effects of compensatory changes in skull dimensions and brain shape when there is craniosynostosis or shortening of certain skul... by Susan P. Knowler (522309)

“…<p>These figures were created using Adobe Photoshop (<a href="http://www.adobe.com/products/photoshopfamily.html" target="_blank">http://www.adobe.com/products/photoshopfamily.html</a>) which enables manipulation of shapes with fixed points facilitating a simple representation of the distortion. a) Normal; the skull is represented by a black box and brain by a grey circle with reference points w, x, y and z. …”

Extinction on biophysical fitness landscape. by C. Scott Wylie (145239)

“…Curves for <i>U<2.5</i> or so have an inflection point, signaling a qualitative transition from extinction to survival as <i>N</i> increases. …”

Visualizing the positive feedback triggered by Cdc42-GTP. by Iker Lamas (580641)

“…(Bottom) Time lapse as in top row, but normalized by subtraction of initial time-point signal and pseudocolored. Note side signal in Opto^Q61L cells (arrowheads), which represents gain of fluorescence intensity in respect to the initial time point (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000600#sec016" target="_blank">Methods</a>). …”

Climate & biomass & phenology & FG composition.csv by Hao Wang (8333367)

“…From 1980 to 2014, annual biomass production of the plant community was monitored using a harvesting method. For our study, we defined annual biomass production as the maximum aboveground biomass observed in August or September (Liu et al. 2018a). …”

Behavior and electrophysiological effects on striatum-nigra circuit after high frequency stimulation. Relevance to Parkinson and epilepsy by Igor Tchaikovsky (10922179)

Use of the Pareto set to define the patterns of primary/promiscuous activity modulation. by Hector Garcia-Seisdedos (158269)

“…(B), (C) and (D) are illustrative examples of the relation between the Pareto set (green data points) and the primary/promiscuous trade-offs. In (B) and (C) the starting variant (marked with a red circle) belongs to the Pareto set and, therefore, increasing the promiscuous activity necessarily implies a decrease of the primary activity. …”

Table 1_Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma.docx by Bin Liao (714989)

“…In addition, we demonstrated that HIF1α and HIF2α promoted IGF1R expression by binding to a specific hypoxia response element (HRE) sequence (5′-GAACGTGCCT-3′) within the IGF1R promoter using dual-luciferase reporter system.…”

Table 2_Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma.docx by Bin Liao (714989)

“…In addition, we demonstrated that HIF1α and HIF2α promoted IGF1R expression by binding to a specific hypoxia response element (HRE) sequence (5′-GAACGTGCCT-3′) within the IGF1R promoter using dual-luciferase reporter system.…”

Table 4_Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma.docx by Bin Liao (714989)

“…In addition, we demonstrated that HIF1α and HIF2α promoted IGF1R expression by binding to a specific hypoxia response element (HRE) sequence (5′-GAACGTGCCT-3′) within the IGF1R promoter using dual-luciferase reporter system.…”

Table_1_Modeling the effects of vaccination, nucleic acid testing, and face mask wearing interventions against COVID-19 in large sports events.DOCX by Zeting Liu (14080026)

“…The generalized SEIR modeling showed that if the general population were vaccinated by inactive vaccines at an efficiency of 0.78, the total number of infectious people during this time period would decrease from 43,455 to 6,417. We assumed that the general population had the same odds ratio of entering the sports stadiums and becoming the audience. …”

Table 3_Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma.docx by Bin Liao (714989)

“…In addition, we demonstrated that HIF1α and HIF2α promoted IGF1R expression by binding to a specific hypoxia response element (HRE) sequence (5′-GAACGTGCCT-3′) within the IGF1R promoter using dual-luciferase reporter system.…”

Table 6_Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma.docx by Bin Liao (714989)

“…In addition, we demonstrated that HIF1α and HIF2α promoted IGF1R expression by binding to a specific hypoxia response element (HRE) sequence (5′-GAACGTGCCT-3′) within the IGF1R promoter using dual-luciferase reporter system.…”

Table_1_Systemic immunological profile of children with B-cell acute lymphoblastic leukemia: performance of cell populations and soluble mediators as serum biomarkers.docx by Maria Perpétuo Socorro Sampaio Carvalho (7300568)

“…On D8 and D15, the patients presented a transition in the immunological profile. While, on D35, they already presented an opposite profile to D0, with an increase in NKT, CD3⁺ T, CD4⁺ T and Treg cells, along with CCL5, and a decrease in the levels of CXCL9, CXCL10 and IL-10, thus demonstrating that B-ALL patients present a complex and dynamic immune network during induction therapy. …”

Table_3_Systemic immunological profile of children with B-cell acute lymphoblastic leukemia: performance of cell populations and soluble mediators as serum biomarkers.docx by Maria Perpétuo Socorro Sampaio Carvalho (7300568)

“…On D8 and D15, the patients presented a transition in the immunological profile. While, on D35, they already presented an opposite profile to D0, with an increase in NKT, CD3⁺ T, CD4⁺ T and Treg cells, along with CCL5, and a decrease in the levels of CXCL9, CXCL10 and IL-10, thus demonstrating that B-ALL patients present a complex and dynamic immune network during induction therapy. …”