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    Data_Sheet_1_A Tool for Computation of Changes in Na+, K+, Cl− Channels and Transporters Due to Apoptosis by Data on Cell Ion and Water Content Alteration.ZIP by Valentina E. Yurinskaya (2735836)

    Published 2019
    “…New experimental data for staurosporine-induced apoptosis of human lymphoma cells U937 have been obtained: the time course of changes in cellular K<sup>+</sup>, Na<sup>+</sup>, Cl<sup>−</sup>, and water content, as well as Rb<sup>+</sup> fluxes as a marker of the Na/K pump activity. Using a newly developed computational tool, we found that alteration of ion and water balance was associated with a 55% decrease in the Na<sup>+</sup>/K<sup>+</sup>-ATPase rate coefficient over a 4-h period, with a time-dependent increase in potassium channel permeability, and a decrease in sodium channel permeability. …”
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