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5-FU induces a decrease in the total cell number in cultures of smooth muscle cells.
Published 2013“…We found an initial reduction of 20% at 0.01 mM up to a reduction of 70% in 10 mM of 5-FU. …”
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In the absence of chloride, two-fold decrease in [Na<sup>+</sup>]<sub>e</sub> shifted GLT-1a E<sub>rev</sub> by −28 mV at both low and high glutamate concentrations.
Published 2015“…<b>(C)</b> I-V curves of DHK sensitive currents obtained form <b>(B)</b> as a result of subtractions of averages of 2 I-V curves in presence of DHK from averages of 4 I-V curves in the absence of DHK at corresponding [Glu<sup>-</sup>]<sub>e</sub> and [Na<sup>+</sup>]<sub>e</sub>. …”
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Image_2_IL-1β enhances cell viability and decreases 5-FU sensitivity in novel colon cancer cell lines derived from African American patients.tif
Published 2022“…When compared to Caucasian American (CA) patients, AAs also have reduced response to the first line standard of care chemotherapeutic agent 5-Fluorouracil (5-FU). Previously, we observed differential gene expression between the two populations, suggesting that colon tumors from AA patients display a decreased antitumor immune response and an increased expression of genes encoding proteins involved in inflammatory processes, such as Interleukin-1β (IL-1β). …”
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GSK343 decreased neuroblastoma viability, proliferation, and motility.
Published 2021“…<p>(A) SK-N-AS, SK-N-BE(2), SH-EP and WAC(2) cells (1.5 × 10<sup>3</sup> cells) were treated with increasing concentrations of GSK343 (0, 5, 15, 25 μM) for 24 hours and viability was measured using alamarBlue<sup>®</sup> assay. …”
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A PPARα Promoter Variant Impairs ERR-Dependent Transactivation and Decreases Mortality after Acute Coronary Ischemia in Patients with Diabetes
Published 2010“…Electrophoretic mobility shift assays showed that the domain bound two known <em>PPARA</em> transcriptional activators, estrogen-related receptor (ERR)-α and -γ and that <em>PPARA</em> G bound with greater affinity than <em>PPARA</em> A (>2-fold; P<0.05). …”
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