Table_2_HIPK3 Inhibition by Exosomal hsa-miR-101-3p Is Related to Metabolic Reprogramming in Colorectal Cancer.docx by Lihuiping Tao (11939750)

“…Xenograft model further confirmed a profoundly improved potency of the synergistic treatment combining both 5-FU and 101-3p inhibitor compared to 5-FU alone.…”

Conceptual framework for analyses of spatial epigenetic structure in a clonal plant population. by Kiwako S. Araki (680112)

“…(a) From the natural population, we obtained three types of spatial information: environmental heterogeneity (vegetation cover), genet distribution (SSR), and epigenetic variation (MS-AFLP). …”

Table_1_Immune Monitoring of Patients With Primary Immune Regulation Disorders Unravels Higher Frequencies of Follicular T Cells With Different Profiles That Associate With Alterat... by María Soledad Caldirola (9575969)

“…To improve our understanding of these conditions, in this work we analyzed the T and B cell compartments of 15 PID patients with dysregulation, including 3 patients with STAT1 GOF mutation, 7 patients with CVID with dysregulation, 3 patients with mutations in CTLA4, 1 patient with CD25 mutation and 1 patient with STAT5b mutation and compared them with healthy donors and with CVID patients without dysregulation. …”

Table_1_The Effects of a Ketogenic Medium-Chain Triglyceride Diet on the Feces in Dogs With Idiopathic Epilepsy.DOCX by Rachel Pilla (380070)

“…We made comparisons between the MCT-KD, standardized placebo diet and baseline pre-trial diet phases. …”

Barium Promotes Anchorage-Independent Growth and Invasion of Human HaCaT Keratinocytes via Activation of c-SRC Kinase by Nguyen Dinh Thang (201359)

“…A SRC kinase specific inhibitor, protein phosphatase 2 (PP2), blocked barium-mediated promotion of anchorage-independent growth and invasion with decreased c-SRC kinase activity. Barium (2.5–5 µM) also promoted anchorage-independent growth and invasion of fibroblasts (NIH3T3) and immortalized nontumorigenic melanocytes (melan-a), but not transformed cutaneous squamous cell carcinoma (HSC5 and A431) and malignant melanoma (Mel-ret) cells, with activation of c-SRC kinase. …”

Data_Sheet_1_Adaptive Pathways of Microorganisms to Cope With the Shift From P- to N-Limitation in Subtropical Plantations.docx by Chaoqun Wang (217429)

“…We found that (i) enzyme activity and microbial biomass and diversity increased with planting density at age 5 but decreased at age 35; (ii) soil microorganisms were P-limited at age 5, but gradually shifted from P- to N-limitation during the development of plantations from 5 to 35 years; and (iii) significantly negative relationships between microbial biomass stoichiometry and enzymatic stoichiometry were observed. …”

Critical Decline of the Eastern Caribbean Sperm Whale Population by Shane Gero (3196446)

“…We address hypotheses that, over a ten-year period of dedicated effort (2005–2015), unit size, numbers of calves and/or calving rates have each declined. …”

Generation, purification, and penetration of rISL1 protein. by Hananeh Fonoudi (278175)

“…Lanes 3 and 4 are rISL1 proteins at 2 different concentrations (5 and 10 µg). The other lines are DNA treated by different amounts of protein. …”

DataSheet1_Pingchan Granule for Motor Symptoms and Non-Motor Symptoms of Parkinson’s Disease: A Randomized, Double-Blind, Placebo-Controlled Study.DOCX by Si-Chun Gu (12135735)

“…</p><p>Results: Generalized estimating equation analyses revealed that the PCG group had significantly better improvement in UPDRS-III score at T1, T2, and T3 [time-by-group interaction, T1: β, −0.92 (95% CI, −1.59–−0.25; p = 0.01); T2: β, −2.08 (95% CI, −2.90–−1.27; p < 0.001); T3: β, −4.54 (95% CI, −5.37–−3.71; p < 0.001))]. The PCG group showed a greater decrease (rate of disease change) in the total UPDRS score between T0 and T2 [−2.23 (95% CI, −2.72–−1.73; p < 0.001) points per week vs. −0.21 (95% CI, −0.80–0.39; p = 0.50) points per week in the placebo group, p < 0.001]. …”

A New Approach to Improving Healthcare Personnel Influenza Immunization Programs: A Randomized Controlled Trial by Larry W. Chambers (704112)

“…No significant differences were observed between the groups at the three points in time. However, there was a 7% increase in the median rates between the Baseline Year and Year Two in the Intervention group, and a 6% decrease in the Control group over the same time period, which was statistically significant (0.071 versus -0.058, p < 0.001).…”

Continual Cell Deformation Induced via Attachment to Oriented Fibers Enhances Fibroblast Cell Migration by Sisi Qin (564059)

“…In the case of en-mass cell migration out of an agarose droplet, fibroblasts on flat surfaces emerged with an enhanced velocity, v = 52μm/h, that decreases to the single cell value, v = 28μm/h within 24 hours and remained constant for at least four days. …”

From Schooling to Shoaling: Patterns of Collective Motion in Zebrafish (<em>Danio rerio</em>) by Noam Miller (120315)

“…Examining zebrafish groups of different sizes from 5 to 50, we show that larger groups are less polarized than smaller groups. …”

The average distance between the the most frequent phenotypes and the patchiness of the visible phenotypic subspace. by Elhanan Borenstein (68815)

“…We also calculate which fraction of all visible phenotypes are included in these phenotypes (solid line). …”

Influence of an elevated CO2 level on life history parameters and hormone pathway or vitellogenin metabolism of the brown planthopper.zip by Yanhui Wang (11324715)

“…We have demonstrated that elevated CO₂ could accelerate the development and improve reproduction of <i>N. lugens</i>, which is related to the transcription levels of JH, MH and Vg.…”

Image_3_Creation of Early Flowering Germplasm of Soybean by CRISPR/Cas9 Technology.png by Jianan Han (7911278)

“…In addition, no off-target effects were observed by predicting and analyzing the potential off-target sites of E1 targets. Significant decreased E1 gene expression of two novel mutants showed that the truncated E1 protein disinhibited GmFT2a/5a and increasing GmFT2a/5a gene expressions resulted obvious early flowering. …”

DataSheet_1_Turbulence affects larval vertical swimming in the cold-water coral Lophelia pertusa.pdf by Vilhelm Fagerström (14234933)

“…Larval movement and water flow were simultaneously recorded, allowing for analysis of individual larval swimming velocities. We showed that the upwards directed swimming speed generally decreased with increasing turbulence, dropping to non-significant in turbulence levels occurring near ocean boundaries. …”

Supplementary file 1_Transspinal stimulation preceding assisted step training reorganizes neuronal excitability and function of inhibitory networks in spinal cord injury: a randomi... by Abdullah M. Sayed Ahmad (18592582)

“…</p>Methods<p>Fourteen participants with chronic SCI received an average of 40 sessions with 30 Hz transspinal stimulation delivered for 30 min during standing (active: n = 4; sham: n = 5) or supine (active: n = 5) followed by 30-min of robotic assisted step training. …”

Data_Sheet_1_Ion Channel Targeted Mechanisms of Anti-arrhythmic Chinese Herbal Medicine Xin Su Ning.PDF by Taiyi Wang (6305579)

“…Our main findings are: (1) On ECG recorded in isolated rat, in the presence of XSN the amplitude of R wave was significantly decreased and the amplitude of T wave was increased significantly; (2) XSN blocked hNaV1.5 channel stably transfected cell line in a dose-dependent manner with an IC₅₀ of 0.18 ± 0.02 g/L; and (3) XSN suppresses hERG channels in a dose-dependent manner with an IC₅₀ of 0.34 ± 0.01 g/L. …”

Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier Bricks by Sofia Benfeito (4345591)

“…Although the lipophilic triphenylphosphonium (TPP⁺) cation is widely used to target antioxidants to mitochondria, TPP⁺-based derivatives have shown cytotoxicity in several biological <i>in vitro</i> models. We confirmed that <b>Mito.TPP</b> is cytotoxic to both human neuronal (SH-SY5Y) and hepatic (HepG2) cells, decreasing intracellular adenosine triphosphate (ATP) levels, leading to mitochondrial membrane depolarization and reduced mitochondrial mass after 24 h. …”

Image_6_Creation of Early Flowering Germplasm of Soybean by CRISPR/Cas9 Technology.png by Jianan Han (7911278)

“…In addition, no off-target effects were observed by predicting and analyzing the potential off-target sites of E1 targets. Significant decreased E1 gene expression of two novel mutants showed that the truncated E1 protein disinhibited GmFT2a/5a and increasing GmFT2a/5a gene expressions resulted obvious early flowering. …”