Computational structural assessment of BReast CAncer type 1 susceptibility protein (BRCA1) and BRCA1-Associated Ring Domain protein 1 (BARD1) mutations on the protein-protein inter... حسب Thirumal Kumar, D.

"…From the analysis, we observed the highest deviation with lowest compactness and a decrease in the intramolecular h-bonds in the BRCA1-BARD1 protein complex with the V11G mutation compared to the native complex or the complexes with other mutations. 2022 Elsevier Inc.…"
احصل على النص الكامل
احصل على النص الكامل

Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2. حسب P, Sneha

"…Molecular docking analysis revealed a decrease in interaction between the protein and ATP in all the 3 mutations, and molecular dynamic simulations of 50 ns showed a loss of stability and compactness in the mutant proteins. …"
احصل على النص الكامل
احصل على النص الكامل

CLINICAL AND ECONOMIC IMPACT OF GENETIC AND NON-GENETIC FACTORS ON INR NORMALIZATION IN PRE-OPERATIVE MANAGEMENT OF WARFARIN PATIENTS حسب ELJILANY, ISLAM AHMED SAYED AHMED

"…To optimize the period of preprocedural warfarin interruption to decrease the incidence of bleeding in case of bridging and the incidence of thromboembolism in case of non-bridging, a study was conducted to determine the influence of CYP2C9, VKORC1, CYP4F2, FII, and FVII genetic polymorphisms and non-genetic factors on INR decline in a cohort of Arabs undergoing a procedure that requires warfarin interruption and developing an algorithm to tailor the duration of warfarin interruption before the procedure. …"
احصل على النص الكامل

Pd nanocrystals encapsulated in MOF-derived Ni/N-doped hollow carbon nanosheets for efficient thermal CO oxidation: unveiling the effect of porosity حسب Ipadeola, Adewale K.

"…This is evidenced in the great ability of Pd/Ni-MOF-HNC to utterly oxidize CO at a lower complete conversion temperature (T100) of 114.5 °C compared with Pd/Ni-MOF-NC (153.8 °C) and Pd/C (201.5 °C) under atmospheric pressure. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Effects of Climate and Atmospheric Nitrogen Deposition on Early to Mid-Term Stage Litter Decomposition Across Biomes حسب Kwon, Taeoh

"…We assessed how macroclimate and atmospheric inorganic N deposition under current and predicted scenarios (RCP 2.6, RCP 8.5) might affect litter mass loss measured after 3 and 12 months. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Origanum Syriacum Inhibits Proliferation, Migration, Invasion and Induces Differentiation of Human Aortic Smooth Muscle Cells حسب AlDisi, Sara

"…Cardiovascular diseases (CVDs) are still the number one cause of morbidity and mortality both in Qatar and worldwide. A major risk factor of CVDs is atherosclerosis, the hardening of blood vessels caused by decreased diameter and formation of plaque. …"
احصل على النص الكامل
احصل على النص الكامل

Flight Scheduling in the Airspace حسب Msakni, Mohamed Kais

"…In this study, we developed a scatter search (SS) to deal with larger instances. …"
احصل على النص الكامل
احصل على النص الكامل

Pharmacoeconomic evaluation of voriconazole vs. liposomal amphotericin B in empiric treatment of invasive fungal infections in Turkey حسب Turner, Stuart J.

"…Univariate sensitivity analysis highlighted that increasing the duration of voriconazole by >1.2 days or decreasing LAmB by >1.0 days changes the result. Monte Carlo Simulation resulted in 69.4% of simulations favouring voriconazole per patient treated.Conclusion: There is a strong likelihood that voriconazole is economically more favourable than LAmB in the empiric treatment of IFI in Turkey.…"
احصل على النص الكامل
احصل على النص الكامل

Service Ethnocentrism: A Conceptual Model (An Abstract) حسب Maher, Amro A.

احصل على النص الكامل
احصل على النص الكامل

Effect of Magnetic Baffles and Magnetic Nanofluid on Thermo-Hydraulic Characteristics of Dimple Mini Channel for Thermal Energy Applications حسب Souayeh, Basma

"…The increment changed to 1.82%, 8.16%, and 22.31% for a pitch = 5 mm and 1.01%, 5.96%, and 21.38% for a pitch = 2.5 mm. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Effect of outdoor temperature on the power-conversion efficiency of newly synthesized organic photosensitizer based dye-sensitized solar cells حسب Mehmood U.

احصل على النص الكامل
احصل على النص الكامل

Trilemma of life cycle carbon, employment, and costs of trucking industry's shift toward automation and electrification حسب Mandouri, Jafar

"…According to the results, while enhanced fuel economy due to autonomous systems can lead up to a 18% and 41% reduction in emissions and costs, electrification of diesel trucks shows remarkable potential, achieving up to a 40% decline in emissions and a 12% saving in life cycle costs. Autonomy and electrification combined could lead to a 50% decrease in emissions and 46% savings in life cycle costs. …"
احصل على النص الكامل
احصل على النص الكامل

Non-linear relationship between real commodity price volatility and real effective exchange rate: The case of commodity-exporting countries حسب Boubakri, Salem

احصل على النص الكامل

The cost associated with the development of the antimicrobial stewardship program in the adult general medicine setting in Qatar حسب Abushanab, Dina

"…The operational costs decreased with the developed ASP. Whereas antimicrobial consumption and resource utilisation, and their associated costs, appear to have declined with the developed ASP, with a cost saving of QAR458 (US$125) per 100-patient beds, the avoided cost was negative, by QAR4,807 (US$1,317) per 100-patient beds, adding to a total QAR4,224 (US$1,160) increase in the 100-patient beds cost after ASP development. …"
احصل على النص الكامل
احصل على النص الكامل

Simulation of thermal comfort and energy demand in buildings of sub-Himalayan eastern India - Impact of climate change at mid (2050) and distant (2080) future حسب Thapa, Samar

احصل على النص الكامل
احصل على النص الكامل

Nutritional quality and health risk of pepper fruit as affected by magnesium fertilization. حسب Lu, Ming

"…As a result, Mg fertilization decreased the comprehensive nutrition level of pepper by 16.6%. …"
احصل على النص الكامل
احصل على النص الكامل

Effects of financial turmoil on financial integration and risk premia in emerging markets حسب Boubakri, Salem

"…The aim of this article is to analyze how financial crises affect the dynamics of international financial integration and of the risk premia in emerging markets. Accordingly, we estimate a variant of the International Asset Pricing Model developed by Carrieri et al. (2007), allowing for time-varying stock market integration, in which we include the foreign currency risk. …"
احصل على النص الكامل
احصل على النص الكامل

Regulation of NKG2D by RKIP: Implications on NK-mediated cytotoxicity and cytokine production حسب Galal, Youssef

احصل على النص الكامل
احصل على النص الكامل

Modification of Pd/CeO2 catalyst by Atomic Layer Deposition of ZrO2 حسب Onn, Tzia Ming

"…Methane-oxidation rates in 0.5% CH4 and 5% O2 were slightly lower on the ZrO2-covered catalyst when both materials were calcined at 673 K but the activity of the ZrO2-modified catalyst did not decrease with catalyst calcination temperature. …"
احصل على النص الكامل
احصل على النص الكامل

Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes حسب Patel, J. P.

"…Experimental hyperlipidemia has shown to decrease cytochrome P450 3A4 and 2C11 expression and to increase liver concentrations and the plasma protein binding of halofantrine (HF) enantiomers. …"
احصل على النص الكامل
احصل على النص الكامل