Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2‑Aminoquinoline Inhibitors by Maris A. Cinelli (1309419)

“…We previously developed a class of membrane-permeable 2-aminoquinoline inhibitors and later rearranged the scaffold to decrease off-target binding. …”

CcnA mutation of Loop A decreases the interaction with the 5′ UTR of P2-<i>ctrA</i> mRNA and 5′ UTR of <i>gcrA</i> mRNA. by Wanassa Beroual (5314028)

Mutation of Thr235 to alanine decreases sumoylation of C/EBPbeta1. by Allison A. Atwood (343105)

Data Sheet 2_Circulating prostaglandin E2 concentrations decrease at birth in premature lambs.docx by Timothy J. R. Panneflek (22702136)

“…As PGE₂ suppresses breathing, PGE₂ concentrations must decrease after birth, but the timing and mechanisms behind this decrease are unknown. …”

A Y45F mutation in hepatitis C virus NS4A causes a decrease in infectious viral titer. by Allison E. Roder (6312761)

The novel <i>carboxylesterase 1</i> variant c.662A>G may decrease the bioactivation of oseltamivir in humans by Jaeseong Oh (3947381)

“…A novel <i>CES1</i> c.662A>G single nucleotide polymorphism (SNP) was predicted to decrease CES1 enzymatic activity in an <i>in silico</i> analysis. …”

Decreased pulmonary cell inflammatory response in FI-A2 and G-A2 peptide vaccinated mice after RSV challenge. by Gertrud U. Rey (501694)

<i>btuE</i> expression results in decreased intracellular ROS. by Felipe A. Arenas (23050)

(R)-albuterol decreases cytokine mRNA levels in activated T cells by Marcela A Ferrada (41716)

“…</p><p></p> (R)-albuterol, (S)-albuterol or racemic albuterol (R + S) at a dose (10M) were added to T (EL-4) cells pre-activated with mitogens Concanavalin A (Con A, 5 μg/ml) and phorbol myristate acetate (PMA, 100 ng/ml) (CP). …”

<i>jun-1</i> mutants are highly susceptible to both Bt strains, while <i>elt-2</i> silencing decreased survival on Bt679 but increased survival on Bt247. by Alejandra Zárate-Potes (9415842)

CC-1⁺ immunostained cell numbers decrease by 2 days after TBI and return to control levels by 5 weeks. by Krista A. Dent (709531)

“…Panels show contralateral (Contra) and ipsilateral (Ipsi) external capsule (EC) at (A,B) 2 days (2d), (C,D) 2 weeks (2w) and (E,F) 5 weeks (5w) (G) In the external capsule numbers of CC-1⁺ oligodendrocytes were decreased by 2d after injury, remained decreased at 2 weeks and returned to normal levels by 5 weeks. …”

Levels of the antioxidant enzyme, MnSOD are decreased in the cortical and hippocampal microvessels. by Susan A. Austin (768265)

UGGT activity decreases in <i>uggt-1(RNAi)</i> worms but no decrease was observed in <i>uggt-2 (RNAi)</i> worms. by Lucila I. Buzzi (198284)

Specific inhibition of ATG5 and ATG7 decrease low glucose-induced LC3-II accumulation. by Delphine Balmer (458897)

“…<p>Lentiviruses expressing specific shRNA were used to decrease the expression of ATG5 and ATG7 as described in material & methods, then each clonal cell colony was treated and cultured as mentioned in material & methods. …”

Decrease in intracellular lipid accumulation in 3T3-L1 cells by baicalein. by Yukari Nakao (3138795)

VH14PEST decreases the toxicity of α-Syn as measured by a proteostatic assay with mhttex1-72QGFP. by David C. Butler (261919)

Increased AHP Amplitude and decreased AP firing in the presence of kainic acid is dependent on the GluR5 subunit. by Barbara Gisabella (330774)

Decreased brain-derived neurotrophic factor plasma levels in psoriasis patients by A.R. Brunoni (5694239)

Proteinuria increases in proportion to podocyte number per glomerular tuft and podocyte density decrease. by Larysa Wickman (3169548)

Respective increase and decrease in Myc and NRF1/TFAM in kidneys from rats administered Tl. by Sho Sugahara (11895828)