Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. Interestingly, <b>4f</b> showed remarkable PI3K/AKT/mTOR inhibitory activity with 0.18-, 0.27-, and 0.39-fold decrease in their concentration (reduction in controls from 6.64, 45.39, and 86.39 ng/mL to 1.24, 12.35, and 34.36 ng/mL, respectively). …”

DnaK inhibits protein synthesis in vivo and in vitro. by Carissa Chan (18310140)

DnaK’s ATPase activity is stimulated by ribosomes and required to reduce protein synthesis. by Carissa Chan (18310140)

DnaK associates with intact ribosomes and not with dismantled ribosomes. by Carissa Chan (18310140)

GFP activity is decreased in DES. by Céline Portal (3876436)

“…AB—PAS and serial immunohistochemical section of the left eye, which received PBS, and paired-right eye which received BAK show a decrease in the number of conjunctival goblet cells producing Muc5b (blue arrows) and non-Muc5b producing (white arrows) cells. …”

Trigger factor hinders DnaK-mediated reduction of protein synthesis. by Carissa Chan (18310140)

Preparations of DnaK protein are pure. by Carissa Chan (18310140)

DnaK does not refold heat-denatured luciferase when incubated in the presence of ribosomes. by Carissa Chan (18310140)

HPV16 PsV infection decreases following SLPI treatment or anti-annexin A2 antibody inhibition of A2t. by Andrew W. Woodham (140650)

<i>Slc13a5</i>^<i>-/-</i> mice had decreased enamel volume as measured with μCT. by Armando R. Irizarry (422739)

Reduced follicles, decreased ovulation and decreased fertilization of female Meox-2-cre/Separase S1121A mutant mice. by Juan Xu (225010)

Table S1 - Human <i>NR5A1</i>/SF-1 Mutations Show Decreased Activity on BDNF (Brain-Derived Neurotrophic Factor), an Important Regulator of Energy Balance: Testing Impact of Novel SF-1 Mutations Beyond Steroidogenesis by Jana Malikova (615672)

Subjects:

Decrease of viral load and ALT at different time points under treatment according to NS5A-inhibitors and interferon administration. by Valeria Cento (103603)

Illustrations of the SeqFold2D network and the Stralign dataset. by Xiangyun Qiu (316117)

A DNA-PKcs-specific inhibitor decreases HBoV1 infection of HAE-ALI. by Xuefeng Deng (138723)

LuxR G37V has decreased DNA-binding activity. by Chelsea A. Simpson (9579303)

Data_Sheet_1_Decrease in wearable-based nocturnal sleep efficiency precedes epileptic seizures.PDF by Laura Gagliano (14378124)

“…Each standard deviation decrease in sleep efficiency and increase in wake after sleep onset was respectively associated with a 1.25-fold (95 % CI: 1.05 to 1.42, p < 0.05) and 1.49-fold (95 % CI: 1.17 to 1.92, p < 0.01) increased odds of seizure occurrence the following day. …”

The decrease of C/EBPα protein during apoptosis involves induction of protein degradation and inhibition of transcription. by Meng Zhao (54299)

“…Then, C/EBPα protein was detected with β-actin as a loading control. Folds of decrease of C/EBPα protein/β-actin ratios against untreated cells are shown as means±SD of three independent experiments. …”

Functional Annotation and pathway analysis of genes decreased more than 2-fold in Cr(VI) transformed cells. by Hong Sun (132232)

Increased relative abundance of GPS progenitors and decreased formation of endocrine cells in Cdk4–null mice. by Montse Garcia-Lavandeira (266392)