Loss of virulence in the SIN kinase mutants is characterized by decreased fungal burden and host response to infection. by Ana Camila Oliveira Souza (8180958)

“…**p = 0.0024 for (B); **p = 0.0031 for (C). An <i>in vitro</i> IL-1β release assay uncovered decreased induction of inflammasome activation by the SIN kinase mutants. …”

NgR1 KO mice exhibited an increase in excitatory synapses and a decrease in inhibitory synapses, indicating an imbalance of synaptic transmission. by Jinwei Zhang (462455)

“…The inhibitory synaptic density of NgR1 mice showed a significant decrease when compared to WT mice (***P <  0.001). …”

The combination of LPS and PFC caused faster clot initiation and decreased clot strength. by Heather F. Pidcoke (9023789)

“…By RM ANOVA, the time effects were obscured by interaction with group: SAL-SAL, p = NS; LPS-SAL, MA increases with time; T0 v T72 and T96, p≤0.05; SAL-PFC: MA drops @ T96, p≤0.05; LPS-PFC: T0 v all others, p≤0.05 with a recovery at T96, (p≤0.05 compared to T72); SAL-PFC: no significant change, p = NS. …”

Suction-electrode recordings from WT and <i>TrUx;GapOx</i> rods. by Ala Morshedian (4165957)

eIF5a interacts with Mfn1 and preserves mitochondrial integrity. by Dong Ma (584680)

Subjects:

Decreased cellular iron uptake increases the <i>P</i>. <i>chabaudi</i> pathogen burden. by Sarah K. Wideman (17118275)

<i>Ang1</i>-deficient mice develop significantly fewer tumors compared to WT mice following AOM-DSS. by Alexander Hu (14755811)

Decreased virulence observed during <i>in planta</i> infection with <i>ΔFgknr4</i>. by Erika Kroll (20537020)

“…In wheat inoculated with <i>ΔFgknr4</i> compared to WT, decreased host colonisation is observed, evidenced by (i) reduced fungal hyphae proliferation, particularly in the thicker adaxial cell layer, (ii) collapsed air spaces in wheat cells, and (iii) increased polymer deposition at the wheat cell walls (black arrows), indicating an enhanced defence response. …”

Loss of ASAP1 results in decreased numbers of neonatal subcutaneous adipocytes and reduced body weight. by Caroline Schreiber (383327)

Ifit2 deficiency decreases CX3CR1 expression in microglia following infection. by Jayasri Das Sarma (652473)

An enhanced clot growth rate before in vitro fertilization decreases the probability of pregnancy by A. N. Balandina (6729380)

Reduction of OPL and decreased number of horizontal cells in P18 Oc-deficient mice. by Michaela Kreplova (9239560)

Summary of structural dynamics of WT and mutant RhoGAPs-RhoA complexes. by Zen Kouchi (14898435)

Subjects:

Activating cAMP synthesis decreases liberation of propionyl-CoA from cholesterol. by Kaley M. Wilburn (12060476)

eIF5a is up-regulated in unruptured AAAs and decreased in ruptured AAAs. by Dong Ma (584680)

Subjects:

Hypomyelination and demyelination in the spinal cord of <i>taiep</i> rats. by Jose R. Eguibar (8563227)

“…<b>E)</b> In the dorsal column a significant decrease in red the myelin fluorescence intensity in <i>taiep</i> rats (blue bar; <i>P<</i> 0.0001, Mann-Whitney U test) with respect to WT rats (black bar). …”

Five genes involved in piRNA biosynthesis were commonly down-regulated in the two <i>enok</i> mutants as compared with the WT control, while the expression levels of <i>piwi</i>, <i>AGO3</i> and <i>aub</i> were not decreased in <i>enok</i> mutants. by Shih-Ying Tsai (3576587)

Delphinidin alters VEGF-A splicing to increase VEGF-A₁₆₅b and decrease total VEGF-A expression. by Megan Stevens (3964886)

“…<p><b>A)</b> Treatment of podocytes with delphinidin chloride (10 μg/ml) under normal glucose (NG; 5 mM glucose + 25 mM mannitol) and high glucose (HG; 30 mM glucose, 1 ng/ml TNFα, 1 ng/ml IL-6, and 100 nM insulin) for 48 hrs increased the protein expression of VEGF-A₁₆₅b relative to total VEGF-A₁₆₅ (quantified in <b>B</b>; *p<0.05 vs NG, †p<0.05 vs HG; n = 3 biological repeats; One-way ANOVA with Bonferroni post-hoc test for comparison between pairs; <b>A</b>—the same blot was first probed with VEGF-A₁₆₅b before stripping and reprobing with panVEGF-A). …”

Etesevimab in combination with JS026 neutralizing SARS-CoV-2 and its variants by Fengze Wang (10452968)

“…A cocktail of etesevimab and JS026 increased neutralizing efficacy against both wild-type SARS-CoV-2 and the recent emergence of Alpha, Beta, Gamma, and Delta variants. …”

Stability parameters for SpGrx3 WT and mutants. by Trang Van Tran (16913946)

“…Hydrophilic-to-hydrophobic substitutions were made in the aromatic cluster, in β1 (E5V and Y7F), adjacent β2 (Y32F and Y32L), both β1 and β2 (E5V/Y32L), and short α2 (R47F). …”