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Decrease of SMAD3 protein, but not SMAD2 in DBA iPSCs.
Published 2015“…The nuclear p-SMAD2 decreased in <i>RPL5</i> mutant and corrected lines. …”
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Genes correlated with SARS-CoV-2 viral load over time are similarly expressed in independent datasets of SARS-CoV-2 infected lung and upper airway cells.
Published 2025“…<p><b>(a)</b> Differential expression patterns for the 112 genes correlated with SARS-CoV-2 viral load across our serial sampling cohort (p<0.001, from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0317033#pone.0317033.g003" target="_blank">Fig 3A</a>) were examined in two independent RNA-seq datasets of SARS-CoV-2 infection: one of lung cancer cell lines (A549 and Calu-3) infected with SARS-CoV-2 at multiplicity-of-Infection (MOI) of 2 for 24 hours (in biological triplicate)[<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0317033#pone.0317033.ref028" target="_blank">28</a>], and one of nasopharyngeal/oropharyngeal samples in 238 patients with COVID-19, other viral, or non-viral acute respiratory illnesses [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0317033#pone.0317033.ref029" target="_blank">29</a>]. …”
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A decrease in circulating CXCR5+CD4+ Tfh cells is associated with HCC progression, and CXCR5+CD4+ Tfh cells are decreased in tumor regions.
Published 2015“…<p>(A) The prevalence of CXCR5+CD4+ Tfh cells decreases with progressive stages in HCC. …”
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Image_5_Consecutive Hypoxia Decreases Expression of NOTCH3, HEY1, CC10, and FOXJ1 via NKX2-1 Downregulation and Intermittent Hypoxia-Reoxygenation Increases Expression of BMP4, NOTCH1, MKI67, OCT4, and MUC5AC via HIF1A Upregulation in Human Bronchial Epithelial Cells.TIF
Published 2020“…Inhibition of HIF1A or NKX2-1 expression by siRNA transfection respectively decreased BMP4/NOTCH1/MKI67/OCT4/MUC5AC and NOTCH3/HEY1/CC10/FOXJ1 expression in the HBE cells cultured under intermittent H/R to the same levels under normoxia. …”
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TUDCA decreases MPO with improved mitochondrial biogenesis, mitochondria-ER contact, and alveolar formation of HOX neonatal rat lungs.
Published 2022“…<p>(<b>A</b>) The increased MPO levels in HOX neonatal lungs are decreased by TUDCA treatment (0.1±0.1-fold; n = 6, p<0.05). …”
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474
Transaldolase deficiency causes a starvation-like response that decreases animal fat content and rewires lipid metabolism gene expression.
Published 2017“…<p><b>(A)</b> Intestinal fat staining decreases from RNAi knockdown of <i>tald-1</i> or <i>cco-1</i>. …”
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475
SIRT5 is a proviral factor.
Published 2022“…<b>E</b>. Decrease in cell-associated viral mRNA levels in A549-ACE2 cells infected with SARS-Cov-2 for 3 days at MOI = 0.1, and treated with SIRT5 and SIRT1 inhibitors Sirt5-i and Ex-527, as shown by RT-qPCR. …”
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