Transfection of human primary adipocytes in suspension with siRNA is associated with decreased expression of targeted proteins. by Gail Kilroy (370499)

PLD1 inhibition decreases the c-Myc-dependent dNTP biosynthetic transcriptional program. by Harry E. Taylor (596259)

WT1 (+KTS) decreases basal and GnRH-stimulated LHβ promoter activity. by Debalina Bagchi (686046)

Decreased Variability of the 6-Minute Walk Test by Heart Rate Correction in Patients with Neuromuscular Disease by Kira P. Prahm (670305)

“…</p><p>Results</p><p>Successive standard 6-minute walk tests showed considerable learning effects between Tests 1 and 2 (4.9%; <i>P</i> = 0.026), and Tests 2 and 3 (4.5%; <i>P</i> = 0.020) in patients. …”

Blocking VIP-signaling decreased inflammation and necrosis in the liver and lung of mCMV-infected mice. by Jian-Ming Li (319425)

ML246 and voluntary exercise decrease cerebral amyloid plaques and ameliorate memory deficits in 5XFAD AD mice. by Altea Rocchi (3278457)

Removal of the blue component of light significantly decreases retinal damage after high intensity exposure by Javier Vicente-Tejedor (4966858)

“…<div><p>Light causes damage to the retina (phototoxicity) and decreases photoreceptor responses to light. The most harmful component of visible light is the blue wavelength (400–500 nm). …”

Positive modulation of mGluR5 decreases spine density in the nucleus accumbens but not in the dorsal striatum. by Kellie S. Gross (3115299)

“…<p>(A) Twenty-four hours after systemic administration, CDPPB (5–10 mg/kg, <i>n</i> = 18 animals) decreased dendritic spine density and frequency of small head diameter spines (0.2 μm bin) compared to vehicle control (<i>n</i> = 8) in the nucleus accumbens core. …”

Oral PTCTS (Particulated Transialidase) Removes Serum Microparticles and Decreases Inflammation in Atherosclerotic Plaques of Rabbits by Garavelo, Sherrira M.

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Decreased endothelial function in a subfailure overstretch RA model was restored with apyrase and P2X7R antagonists FCF and A740003. by Padmini Komalavilas (402160)

Overexpression of ZnT3 and ZnT10 decreases ROS and prevents Ang II-induced senescence. by Nikolay Patrushev (179006)

Simulated response to Ach at activated NALCN channels and decreased phosphodiesterase (PDE) activity in low glucose. by Leonid E. Fridlyand (2636968)

“…<p>(A) PM potentials (V_p); (B) [Ca²⁺]_c and [Ca²⁺]_ER; (C) Cytoplasmic cAMP and IP₃ concentrations. …”

Alp5a and Alp5b are not individually required for asexual blood stage propagation, but simultaneously, they are indispensable for parasite viability. by Aastha Varshney (22601181)

“…<p><b>(A)</b> Parasites transfected with constructs targeting Alp5a and Alp5b, tagged with mCherry and GFP respectively, predominantly gave rise to single knockout populations expressing only one of the two fluorophores. …”

miR-214 decreased the number of viable cells and induced apoptosis in HSA cell lines. by Kazuki Heishima (791938)

“…<p>(A) Cell viability was assessed by performing the MTT assay. miR-214-transfection decreased the number of viable cells in HSA cell lines and that of control EC. …”

Ba₂NaClP₂O₇: Unprecedented Phase Matchability Induced by Symmetry Breaking and Its Unique Fresnoite-Type Structure by Jie Chen (5892)

“…Herein, we report a unique Ba₂NaClP₂O₇ representing the first phase-matchable example of the fresnoite family, which exhibits excellent NLO properties, including short absorption edge (<176 nm, ca. 7.0 eV), strong second-harmonic generations at the incident lasers of 850–1110 nm (obv. 0.9–1.3 × KDP; cal. …”

Structure–Activity Relationship of 3‑Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors by Mirko Scortichini (4007366)

“…We now expand the structure–activity relationship of pyrimidine nucleotides as human CD73 inhibitors. 4-Chloro (MRS4598 <b>16</b>; <i>K</i>_i = 0.673 nM) and 4-iodo (MRS4620 <b>18</b>; <i>K</i>_i = 0.436 nM) substitution of the <i>N</i>⁴-benzyloxy group decreased <i>K</i>_i by ∼20-fold. …”

Structure–Activity Relationship of 3‑Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors by Mirko Scortichini (4007366)

“…We now expand the structure–activity relationship of pyrimidine nucleotides as human CD73 inhibitors. 4-Chloro (MRS4598 <b>16</b>; <i>K</i>_i = 0.673 nM) and 4-iodo (MRS4620 <b>18</b>; <i>K</i>_i = 0.436 nM) substitution of the <i>N</i>⁴-benzyloxy group decreased <i>K</i>_i by ∼20-fold. …”

Structure–Activity Relationship of 3‑Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors by Mirko Scortichini (4007366)

“…We now expand the structure–activity relationship of pyrimidine nucleotides as human CD73 inhibitors. 4-Chloro (MRS4598 <b>16</b>; <i>K</i>_i = 0.673 nM) and 4-iodo (MRS4620 <b>18</b>; <i>K</i>_i = 0.436 nM) substitution of the <i>N</i>⁴-benzyloxy group decreased <i>K</i>_i by ∼20-fold. …”

UV dose responses by sequential UV-A followed by UV-C exposure for (A) MS2 and (B) E. coli K-12 in PBS and NOM. by Daniel Ma (12698752)

A PPARα Promoter Variant Impairs ERR-Dependent Transactivation and Decreases Mortality after Acute Coronary Ischemia in Patients with Diabetes by Sharon Cresci (53599)

“…Consistent with previous descriptions of PPARα in experimental models and human disease, we describe a novel <em>PPARA</em> promoter SNP that decreases transcriptional activation of <em>PPARA</em> and protects against mortality in diabetic patients after ACS.…”