Down-regulation of BRCA1 in developing mouse retina implicates the attenuation of DNA repair. by Pei Chen (252989)

“…BRCA1 in retina significantly and gradually decreased with the age of the animal. <b>C,</b> DNA end joining efficiency was detected by rejoining the linearized plasmid [pcDNA3–1-His] with 5′ overhang [EcoRI] and blunt [EcoRV] ends in the presence of the nuclear protein extracts from retinal neurocytes. …”

Platelet thrombus formation on immobilized VWF in the presence of HbS. by Gowtham K. Annarapu (2622811)

“…Further the thrombus was decreased in presence of 5 μM AA1-50 <b>(B3)</b> but not in presence of control peptide <b>(B4)</b>.…”

Plumes in uniform flow with two-layer stratification by Iran Eduardo Lima Neto (4662052)

Plumes in uniform flow with two-layer stratification by Iran Eduardo Lima Neto (4662052)

Preparation and Characterization of Homologous Diiron Dithiolato, Diselenato, and Ditellurato Complexes: [FeFe]-Hydrogenase Models by Mohammad K. Harb (2331892)

“…Treatment of Fe₃(CO)₁₂ with 3,3-bis(thiocyanatomethyl)oxetane (<b>1</b>) or a mixture of 2-oxa-6,7-dithiaspiro[3.4]octane (<b>2a</b>) and 2-oxa-6,7,8-trithiaspiro[3.5]nonane (<b>2b</b>) in toluene at reflux afforded the model compound Fe₂(μ-S₂C₅H₈O)(CO)₆ (<b>3</b>). …”

Identifying the groups becomes harder when the degradation chain is long, especially for groups catalyzing upstream reactions. by Yuanchen Zhao (12905580)

“…As the chain becomes longer, the ability to recover the most upstream group drops quickly, whereas the direct producers are adequately recovered up to length 5. In both panels, shading indicates the standard error of the mean over 50 synthetic datasets, circles indicate data points for Metropolis while triangles for random groupings.…”

Data_Sheet_2_Pharmacokinetics and tolerability of the dual TORC1/2 inhibitor sapanisertib in combination with the MEK inhibitor trametinib in dogs.docx by Bih-Rong Wei (369553)

“…Animals were monitored for PK following single dose and 17-day repeat dosing, and by clinical observations, hematology, serum biochemistry, coagulation studies and urinalyses. A single trametinib dose (0.025 mg/kg), sulfated as dimethyl sulfoxide which enhanced its absorption, reached mean maximum concentration (C_max) 0.64 ng/mL [18% coefficient of variation (CV)] at a median time to maximum concentration (T_max) of 1.5 h (hr), and mean area under the concentration-time curve (AUC) 16.8 hr^*ng/mL (14%CV), which were similar when given alone or in combination with sapanisertib. …”

Data_Sheet_1_Pharmacokinetics and tolerability of the dual TORC1/2 inhibitor sapanisertib in combination with the MEK inhibitor trametinib in dogs.docx by Bih-Rong Wei (369553)

“…Animals were monitored for PK following single dose and 17-day repeat dosing, and by clinical observations, hematology, serum biochemistry, coagulation studies and urinalyses. A single trametinib dose (0.025 mg/kg), sulfated as dimethyl sulfoxide which enhanced its absorption, reached mean maximum concentration (C_max) 0.64 ng/mL [18% coefficient of variation (CV)] at a median time to maximum concentration (T_max) of 1.5 h (hr), and mean area under the concentration-time curve (AUC) 16.8 hr^*ng/mL (14%CV), which were similar when given alone or in combination with sapanisertib. …”

Spatial and temporal coordination of traction forces in one-dimensional cell migration by Sangyoon J. Han (2936559)

Direct Visualization of the Feedback Pulse by Leor S Weinberger (274196)

“…</p> <p>(E) A replotting of regression fit from <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0050009#pbio-0050009-g005" target="_blank">Figure 5</a>C but with the simulation for Tat included, showing that the model predicts both an exponential/quadratic increase in GFP and a pulse of Tat_A with a peak at 6–8 h.…”

Myotonia-causing mutations and the putative binding pocket of the 9-AC inhibitor. by Kaituo Wang (6193994)

“…Therefore, the phenotype may reflect a decreased chloride affinity of an extracellularly accessible site. …”

Image_1_Fluctuations in emergency department visits related to acute otitis media are associated with extreme meteorological conditions.pdf by Michael Nieratschker (14765098)

“…Prolonged extreme weather conditions over three days, however, significantly increased the cRR for AOM-related EVs to 3.15 [1.26–7.88; p = 0.014] and 2.14 [1.14–4.04; p = 0.018] at mean temperatures of −4°C (1^st-percentile - p₁) and 0°C (p₅) on the same day. …”

Table_1_Fluctuations in emergency department visits related to acute otitis media are associated with extreme meteorological conditions.docx by Michael Nieratschker (14765098)

“…Prolonged extreme weather conditions over three days, however, significantly increased the cRR for AOM-related EVs to 3.15 [1.26–7.88; p = 0.014] and 2.14 [1.14–4.04; p = 0.018] at mean temperatures of −4°C (1^st-percentile - p₁) and 0°C (p₅) on the same day. …”

Data_Sheet_1_Impact of pesticide regulations on mortality from suicide by pesticide in China: an interrupted time series analysis.PDF by Yongfu Yan (16927830)

“…</p>Results<p>The standardized pesticide suicide rate decreased by 60.5% from 6.50 in 2006 to 2.56 per 100,000 in 2018. …”

DataSheet_1_An integrative multi-omic analysis defines gut microbiota, mycobiota, and metabolic fingerprints in ulcerative colitis patients.docx by Matteo Scanu (13197234)

“…</p>Results<p>In the UC cohort, we reported the increase of Streptococcus, Bifidobacterium, Enterobacteriaceae, TM7-3, Granulicatella, Peptostreptococcus, Lactobacillus, Veillonella, Enterococcus, Peptoniphilus, Gemellaceae, and phenylethyl alcohol; and we also reported the decrease of Akkermansia; Ruminococcaceae; Ruminococcus; Gemmiger; Methanobrevibacter; Oscillospira; Coprococus; Christensenellaceae; Clavispora; Vishniacozyma; Quambalaria; hexadecane; cyclopentadecane; 5-hepten-2-ol, 6 methyl; 3-carene; caryophyllene; p-Cresol; 2-butenal; indole, 3-methyl-; 6-methyl-3,5-heptadiene-2-one; 5-octadecene; and 5-hepten-2-one, 6 methyl. …”

LGR4 is required for RSPO1-induced Wnt/β-catenin signaling. by Heinz Ruffner (150990)

“…(b) Expression of LGR4, LGR5 and LGR6 rescue LGR4 siRNA-elicited decrease in RSPO1-induced STF reporter activation. …”

Table_1_The Extent of Alcohol-Related Problems Among College and University Students in Norway Prior to and During the COVID-19 Pandemic.DOCX by Ove Heradstveit (10307177)

“…</p>Findings<p>37.0% of male students and 24.1% of female students reported either risky, harmful, or dependent alcohol use in 2021, compared with 55.0% of male students and 43.6% of female students in 2018. This decrease in alcohol-related problems was most pronounced for dependent alcohol use, where we observed a 57% relative reduction among male students (from 3.5% in 2018 to 1.5% in 2021) and a 64% relative reduction among female students (from 1.4% in 2018 to 0.5% in 2021).…”

Effect of positive end-expiratory pressure (PEEP) on left ventricular (LV) filling by Thomas Luecke (62130)

data.zip by Dapang Rao (11031348)

“…</a> In addition, INPP4B、HPGD、IGFBP5 and IL1R2 genes were upregulated, and PRKACB、TMSB4X and CCND1 downregulated in DOCK1 knockout cells. …”

Data_Sheet_1_Screening Deep Eutectic Solvents for CO2 Capture With COSMO-RS.ZIP by Yanrong Liu (537906)

“…To improve the performance of COSMO-RS, 502 data points of CO₂ solubility in the DESs (1:2, 1:3, 1:4, 1:5) were used for correcting COSMO-RS with a temperature-pressure dependent parameter, and the CO₂ solubility in the DES (1:6) was predicted to further verify the performance of the corrected model. …”