Bortezomib in combination with the PLK1 inhibitor BI 2536 induces a significant downregulation of the total levels and phosphorylation of Bcr-Abl, a decrease of downstream phosphorylated STAT5 and a caspase-dependent cell death in TKIs-resistant and –sensitive K562 cell lines. by Octavian Bucur (470431)

“…K562 and K562-R cells were treated with 9nM bortezomib and 8nM BI 2536 for 60h, followed by the detection of Bcr-Abl and phosphorylated STAT5. The combined treatment resulted in a marked decrease of the total levels of Bcr-Abl, which correlates with a decrease in the phosphorylation of the downstream STAT5 protein, in both K562 and K562-R cells. β-Actin was used as an internal loading control. …”

Experiment 1: Comparison of effort and delay discounting. by Miriam C. Klein-Flügge (713481)

“…The sigmoidal model was included because it fulfills two particular features: it can obtain initially concave shapes, in line with work showing that the sense of effort increases as a power function of the target force with decreasing sensitivity at lower effort levels; and it entails a turning point after which effort discounting becomes progressively less steep. …”

(R+S) and (R)-albuterol decrease NF-κB activity by Marcela A Ferrada (41716)

“…After transfection, (R)-albuterol (R), (S)-albuterol (S), or racemic albuterol (R+ S) were added to cells pre-activated with (ConA, 5 μg/ml) and (PMA, 100 ng/ml) (CP) and then treated with (R)-, (S)-, or (R+S)-albuterol (Fig. 6). …”

Treatment of serine protease inhibitor (AEBSF) in the uterus decreases the number of sperm in the oviduct. by Shuai Li (65944)

Spatial training decreases the association between Ndfip1 and Nedd4 and decreases endogenous Beclin 1 ubiquitination in the hippocampus. by Wei-Lun Hsu (1756123)

“…Endogenous Beclin 1 ubiquitination level is decreased in Nedd4 siRNA-transfected rats (t_1,6 = 5.78, <i>p</i> = 0.001). …”

D120, E124 and E127 in the VPS52 CC interact with RNF41 resulting in decreased RNF41 oligomerization. by Delphine Masschaele (4040204)

Breathing Rate decreases over time during prolonged anesthesia. by Lucie A. Low (328214)

Tumor volume decreases with increasing <i>Salmonella</i> dosage. by Robert A. Kazmierczak (3140379)

5-HT supplementation inhibits mitophagy. by Li Gao (131516)

Expression of SPDEF in TRAMP C2 prostate adenocarcinoma cells decreased cell growth, reduced migration and colony formation on soft agar. by Xin-Hua Cheng (154368)

“…Control and SPDEF-expressed TRAMP C2 cells were seeded in triplicates and counted at different time points using hemocytometer. <b>C</b>. Overexpression of SPDEF decreased migration of TRAMP C2 adenocarcinoma cells <i>in vitro</i>. …”

PEITC activates leptin signaling in differentiated SH-SY5Y cells. by Miho Yagi (5921252)

Decrease of p38 MAPK phosphorylation in HL60 and KG1a cells exposed to 5-Fluorouridine (FUrd) after cell pretreatment with p38 MAPK pathway inhibitor SB202190. by Sabine Matou-Nasri (2938941)

Exogenous IL-15 decreases the fraction but not the absolute number of CD25^High CD4⁺ T cells. by Tom L. Van Belle (306406)

ABCC3 overexpression decreases the retention of anti-cancer agents. by Sai A. Balaji (1452556)

(R)-albuterol decreases cytokine protein levels in activated T cells by Marcela A Ferrada (41716)

“…</p><p></p> (R)-albuterol, (S)-albuterol or racemic albuterol (R + S) at a dose (10M) were added to T (EL-4) cells pre-activated with mitogens Concanavalin A (Con A, 5 μg/ml) and phorbol myristate acetate (PMA, 100 ng/ml) (CP). …”

(R)-albuterol decreases cytokine levels in activated murine splenocytes by Marcela A Ferrada (41716)

“…</p><p></p> (R)-albuterol (R), (S)-albuterol (S) or racemic albuterol (R + S) at a dose (10M) were added to murine splenocytes pre-activated with mitogens Concanavalin A (Con A, 5 μg/ml) and phorbol myristate acetate (PMA, 100 ng/ml) (CP), (Fig 3 A, B). …”

Dexamethasone decreases PGC-1α protein expression and transcription. by Jill A. Rahnert (2872766)

“…<p>(A) Treatment of L6 myotubes with Dex (100nM, 48hrs) decreased PGC-1α protein expression (p = 0.01). n = 3/treatment from 3 experiments. …”

Dexamethasone decreases CRTC1 and CRTC2 nuclear localization. by Jill A. Rahnert (2872766)

“…<p>Treatment of L6 myotubes with Dex (100nM, 48hrs) decreased (A) total CRTC1 (p = 0.004 and CRTC2 protein (p = 0.0007). n = 9/treatment from 3 experiments. …”

Decreasing mean transistor size since 2000. by David Burg (8209752)

Establishment of PANC-1 clone cells. by Noriko Kawai (6694010)