Image1_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.TIF by Ádám István Horváth (15443678)

“…Introduction<p>Monoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under clinical development for neuropathic pain and characterized the mouse model through complex functional, in vivo imaging, and morphological techniques.…”

Table1_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.docx by Ádám István Horváth (15443678)

“…Introduction<p>Monoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under clinical development for neuropathic pain and characterized the mouse model through complex functional, in vivo imaging, and morphological techniques.…”

Image3_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.TIF by Ádám István Horváth (15443678)

“…Introduction<p>Monoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under clinical development for neuropathic pain and characterized the mouse model through complex functional, in vivo imaging, and morphological techniques.…”

Image2_Novel multitarget analgesic candidate SZV-1287 demonstrates potential disease-modifying effects in the monoiodoacetate-induced osteoarthritis mouse model.TIF by Ádám István Horváth (15443678)

“…Introduction<p>Monoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under clinical development for neuropathic pain and characterized the mouse model through complex functional, in vivo imaging, and morphological techniques.…”

Long-term use of cover crops and no-till shift soil microbial community life strategies in agricultural soil by Radomir Schmidt (1956940)

“…In long-term experimental plots at the West Side Research and Extension Center in California’s Central Valley, we characterized soil microbial communities in the presence or absence of physical disturbance due to tillage, in the presence or absence of cover crops, and at three depths: 0–5, 5–15 and 15–30 cm. …”

Over-expression of NF-Y or USF increases <i>Miwi</i>-luciferase activity. by Yu Hou (164094)

“…All transfection experiments were repeated at least three times and the data are shown as the fold increase or decrease over the luciferase activity of pGL3-5M4. …”

CYP dosing conditions differentially altered PLCβ2 expression in circumvallate taste buds. by Eugene R. Delay (405477)

“…<p>(A). PLCβ2+ cells (magenta) in taste buds after saline injections (Saline, top row), a single injection of 75 mg/kg CYP (1CYP, middle row), or five injections of 15 mg/kg CYP (5CYP, bottom row) at 2 days (left column), 6 days (middle column), and 10 days (right column) post injection. …”

Text S1 - Down-Regulating Sphingolipid Synthesis Increases Yeast Lifespan by Xinhe Huang (185390)

“…Figure S2: Myriocin treatment decreases cell size. DBY746 cells were grown with and without myriocin (Myr) as in a CLS assay using SDC medium (pH 4.5, 3X iron). …”

Table_1_Validation and analysis of expression, prognosis and immune infiltration of WNT gene family in non-small cell lung cancer.docx by Jianglin Wang (1569508)

“…Compared with that of normal tissues, WNT2/2B/3A/4/7A/9A/9B/11 expressions decreased, while WNT3/5B/6/7B/8B/10A/10B/16 expressions increased in lung adenocarcinoma (LUAD); WNT2/3A/7A/11 expressions were lessened, while WNT2B/3/5A/5B/6/7B/10A/10B/16 expressions were enhanced in squamous cell lung cancer (LUSC). …”

McDonald versus Shirodkar cervical cerclage for the prevention of preterm birth: impact of body mass index by Reinaldo Figueroa (5432579)

“…</p> <p><b>Results:</b> Of 95 women, 47 (49.5%) received a Shirodkar, and 48 (50.5%) a McDonald cerclage. 16 women (16.8%) were categorized as normal weight, 35 (36.8%) as overweight, and 44 (46.3%) as obese. …”

Table_2_Validation and analysis of expression, prognosis and immune infiltration of WNT gene family in non-small cell lung cancer.docx by Jianglin Wang (1569508)

“…Compared with that of normal tissues, WNT2/2B/3A/4/7A/9A/9B/11 expressions decreased, while WNT3/5B/6/7B/8B/10A/10B/16 expressions increased in lung adenocarcinoma (LUAD); WNT2/3A/7A/11 expressions were lessened, while WNT2B/3/5A/5B/6/7B/10A/10B/16 expressions were enhanced in squamous cell lung cancer (LUSC). …”

NHERF1 protein levels are reduced by both high and low-risk E6 proteins. by Camille M. Drews (4721175)

“…Titrations of the indicated E6 proteins were co-transfected with FLAG_E6AP_WT (1 ug), HA_GFP (0.02 ug), and either HA_NHERF1 (0.5 ug) or p53 (0.5 ug) in murine 8B9 cells. With increased E6 expression, NHERF1 decreased for each E6 protein parallel with p53. …”

Data_Sheet_1_Identification of Valerate as Carrying Capacity Modulator by Analyzing Lactiplantibacillus plantarum Colonization of Colonic Microbiota in vitro.docx by Julia Isenring (3533741)

“…However, extensive knowledge about host-independent microbe-microbe interactions is lacking. Here, we investigated such colonization process using a derivative of the model probiotic Lactiplantibacillus plantarum WCFS1 into continuously cultivated gut microbiota in the intestinal PolyFermS fermentation model inoculated with five independently immobilized human adult fecal microbiota. …”

Regulation of Cyclin E by transcription factors of the naïve pluripotency network in mouse embryonic stem cells by Fabrice Gonnot (7323194)

“…We observed that mESCs express a low level of miR-15a and that transfection of a miR-15a mimic decreases <i>Cyclin E</i> mRNA level. …”

S1 Dataset - by Chenyi Xia (11283023)

“…Our results showed elevated H₂O₂ levels and monoamine oxidase (MAO) activity, and conversely, a decrease in the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the hippocampus of AD rats. …”

Schematic overview of ERS signaling pathways under basal and <i>E</i>. <i>multilocularis</i> infection stressed conditions. by Michael Weingartner (11949789)

“…During ERS, increased levels of miR-1839-5p potentially control the expression of the IRE1α gene, which contains a predicted target site in its 3’-UTR for this miR, thereby affecting the cellular ERS response. …”

WSSV-induced saturated LCFAs activate <i>Chi2</i> expression. by Xin-Xin Wang (135520)

“…The saturated LCFAs were administered to the shrimp hemocoel at 5 μg per shrimp. DMSO was used as a control. <i>Chi2</i> expression was detected 12 h later using qRT-PCR. …”

Contractile proteins, leiomodin1 (LMOD1), myocardin (MYOCD) and MEF2C are downregulated in pulmonary artery smooth muscle cells (hPASMCs) in pulmonary arterial hypertension (PAH). by Sanghamitra Sahoo (2657638)

“…Images from lung sections showed a marked decrease in LMOD1 expression (red fluorescence) in the vessel wall, primarily the media, of PAH samples compared to non-PAH group; DAPI nuclear staining (blue), (<b>A</b>). …”

Quantification of Cre recombinase efficiency. by Rosa-Eva Huettl (113537)

“…Quantification (J) shows a 2-fold decrease in the numbers of <i>Npn-1</i> expressing sensory neurons (positive for Isl-1) in mutant embryos to 10.4%±0.8% at brachial and 13.5%±0.4% at lumbar levels (<i>n</i> = 3, <i>p</i>^brachial<0.005; <i>p</i>^lumbar<0.0005). …”

Chronic treatment with rosiglitazone (10–20 mg/kg/day) normalized hyperglycemia and improved glucose tolerance in <i>db</i>/<i>db</i> mice. by Harshita Chodavarapu (408580)

“…Repeated measures two-way ANOVA using a Bonferroni’s posthoc test showed that treatment with rosiglitazone caused a significant decrease in blood glucose levels of <i>db</i>/<i>db</i> mice [F (3, 54) = 176.04], <i>p</i><0.0001. …”