Influence of Thiolate Ligands on Reductive N−O Bond Activation. Probing the O₂⁻ Binding Site of a Biomimetic Superoxide Reductase Analogue and Examining the P... by Gloria Villar-Acevedo (2232583)

“…Like NO-bound <i>trans</i>-cysteinate-ligated SOR (SOR-NO), the rhombic <i>S</i> = 3/2 EPR signal of NO-bound <i>cis</i>-thiolate-ligated [Fe(S^Me₂N₄(tren)(NO)]⁺ (<b>2</b>; <i>g</i> = 4.44, 3.54, 1.97), the isotopically sensitive ν_NO(ν_¹⁵NO) stretching frequency (1685(1640) cm⁻¹), and the 0.05 Å decrease in Fe−S bond length are shown to be consistent with <i>the oxidative addition of NO to Fe(II)</i> to afford an Fe(III)−NO⁻ {FeNO}⁷ species containing high-spin (<i>S</i> = 5/2) Fe(III) antiferromagnetically coupled to NO⁻ (<i>S</i> = 1). …”

Influence of Thiolate Ligands on Reductive N−O Bond Activation. Probing the O₂⁻ Binding Site of a Biomimetic Superoxide Reductase Analogue and Examining the P... by Gloria Villar-Acevedo (2232583)

“…Like NO-bound <i>trans</i>-cysteinate-ligated SOR (SOR-NO), the rhombic <i>S</i> = 3/2 EPR signal of NO-bound <i>cis</i>-thiolate-ligated [Fe(S^Me₂N₄(tren)(NO)]⁺ (<b>2</b>; <i>g</i> = 4.44, 3.54, 1.97), the isotopically sensitive ν_NO(ν_¹⁵NO) stretching frequency (1685(1640) cm⁻¹), and the 0.05 Å decrease in Fe−S bond length are shown to be consistent with <i>the oxidative addition of NO to Fe(II)</i> to afford an Fe(III)−NO⁻ {FeNO}⁷ species containing high-spin (<i>S</i> = 5/2) Fe(III) antiferromagnetically coupled to NO⁻ (<i>S</i> = 1). …”

Juvenile demyelination leads to a decrease in axonal complexity of PFC PV interneurons. by Sara Hijazi (21656615)

“…</b> Quantification of the overall myelin intensity in PFC of both groups shows a clear loss of myelin in the juvenile demyelination group (<i>t test; n = 6/5 mice per group, ***p < 0.001</i>). …”

<b>When more isn’t better: Sperm competition decreases fertilization success and motile sperm in two sea urchin species</b> by Luisa Kumpitsch (20874095)

DataSheet_1_Inherited Tolerance in Cattle to the Apicomplexan Protozoan Theileria parva is Associated with Decreased Proliferation of Parasite-Infected Lymphocytes.docx by Perle Latre de Late (11497924)

“…We reveal here that first- and second-generation descendants of a single Bos indicus bull survived severe challenge with T. parva, (overall survival rate 57.3% compared to 8.7% for unrelated animals) in a series of five field studies. …”

siRNA-mediated APP-BP1 knock-down significantly decreases BrdU-incorporated fetal neural stem cells. by Yuyoung Joo (236048)

Identification and Characterization of a Leoligin-Inspired Synthetic Lignan as a TGR5 Agonist by Alexander F. Perhal (20946742)

“…However, the underlying molecular targets are still unknown. In this study, we identify the natural product-inspired synthetic structural analogue of leoligin, LT-188A (<b>1</b>), as a novel nonsteroidal TGR5 agonist. …”

B-THP-Ts decrease cellular ATP levels. by Lindsay B. Tulloch (1266861)

Cleavage of osmosensitive transcriptional factor NFAT5 by Coxsackieviral protease 2A promotes viral replication by Ye Qiu (363315)

“…In this study, we aimed to understand the mechanism by which NFAT5 interferes with infection of Coxsackievirus B3 (CVB3), a major cause of viral myocarditis. …”

Decrease in circulating iNKT cell activation during regadenoson (RA) infusion into patients with COVID-19. by Joseph Rabin (7399436)

Subjects:

Community weighted mean (CWM) of the three traits that we included in the measure of functional diversity for wood decomposing beetles captured around young (green) and veteran (br... by Ross Wetherbee (10326282)

Mapping Pathological Phenotypes in a Mouse Model of CDKL5 Disorder by Elena Amendola (565348)

“…Here we describe the physiological, molecular, and behavioral phenotyping of a <i>Cdkl5</i> conditional knockout mouse model of CDKL5 disorder. …”

Table_5_PRMT5 Interacting Partners and Substrates in Oligodendrocyte Lineage Cells.DOCX by David K. Dansu (12252515)

“…This analysis identified a similar number of peptides in the two subcellular fractions and a total number of 57 proteins with statistically decreased symmetric methylation of arginine residues in the CRISPR-PRMT5 knockdown compared to control. …”

Source data for Figs 2E, 3A, 4A and 5B. by Isabel Raposo (21615517)

“…To date, it remains unclear whether periodic and aperiodic temporal structure reflect distinct neural mechanisms. Here, we combined computational simulations with a multimodal approach encompassing five experiments, and three different variants of classic spatial attention paradigms, to differentiate aperiodic from oscillatory-based sampling. …”

<i>TBX5</i> R264K acts as a modifier to develop dilated cardiomyopathy in mice independently of T-box pathway by Nariaki Miyao (8655054)

“…We identified a <i>TBX5</i> variant (c.791G>A, p.Arg264Lys), that is over-represented in cardiomyopathy patients. …”

Video_5_Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder.avi by Valerio Laghi (12228728)

“…Bath exposure, as well as microinjection in the coelom, pericardium, brain ventricle, or bloodstream, resulted in a rapid decrease of SARS-CoV-2 RNA in wild-type larvae. …”

table5_Identification of Plitidepsin as Potent Inhibitor of SARS-CoV-2-Induced Cytopathic Effect After a Drug Repurposing Screen.pdf by Jordi Rodon (201558)

“…Here, we have screened existing drugs approved for human use in a variety of diseases, to compare how they counteract SARS-CoV-2-induced cytopathic effect and viral replication in vitro. …”

TCR-induced proximal signaling is decreased in <i>Gimap5</i> deficient T cells. by Xi-Lin Chen (803969)

ST2-104 decreases the Aβ_25-35-mediated increase in intracellular Ca²⁺. by Yingshi Ji (9013004)

JBPOS0101 decreased Amyloid Beta (Aβ) aggregates in the cortex and hippocampal regions in 5xFAD mouse brains. by Jihoon Jeong (4852690)