Image 1_Volumetric modulated arc therapy total body irradiation improves toxicity outcomes compared to 2D total body irradiation.jpeg by Caressa Hui (19676509)

“…However, there is limited evidence of whether improved organ sparing translates to decreases in toxicities and how its toxicities compare to those of the 2D technique. …”

Epigenetic Inactivation of Notch-Hes Pathway in Human B-Cell Acute Lymphoblastic Leukemia by Shao-Qing Kuang (217209)

“…Aberrant methylation of Notch3 and Hes5 in B-ALL was associated with gene silencing and was accompanied by decrease of H3K4 trimethylation and H3K9 acetylation and gain of H3K9 trimethylation and H3K27 trimethylation. 5-aza-2′-deoxycytidine treatment restored Hes5 expression and decreased promoter hypermethylation in most leukemia cell lines and primary B-ALL samples. …”

Evaluation of cell damage and modulation of cytokines TNF-α, IL-6 and IL-10 in macrophages exposed to PpIX-mediated photodynamic therapy by R. D. R. Tiveron (7451870)

“…PDT increased TNF-α and IL-10, particularly in the presence of LPS, and decreased the production of IL-6 to 10-fold. PDT causes cellular stress, induces NO radicals and leads to DNA degradation, generating a cytotoxic microenvironment. …”

Evaluation of cell damage and modulation of cytokines TNF-α, IL-6 and IL-10 in macrophages exposed to PpIX-mediated photodynamic therapy by R. D. R. Tiveron (7451870)

“…PDT increased TNF-α and IL-10, particularly in the presence of LPS, and decreased the production of IL-6 to 10-fold. PDT causes cellular stress, induces NO radicals and leads to DNA degradation, generating a cytotoxic microenvironment. …”

Glycolytic inhibitor 2-DG alters downstream AMPK and mTOR signaling, and neuronal gene expression, but does not affect Wnt signaling. by Roaya S. Alqurashi (11243136)

“…The levels of activated AMPK and activated P70S6K were detected by quantitative western blot from extract of the hippocampus from 5 days post SE mice, in the presences and absence of 2DG (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0252282#sec016" target="_blank">Methods</a>). …”

TNF-Tg male mice have greater tissue area compared to WT litter mates measured via histomorphometry. by Richard D. Bell (4752660)

“…Interestingly, when normalized to total area, there was a significant decrease in the White area at 3, 4, and 5.5 months in TNF-Tg mice compared to WT littermates (<b>K;</b> *p<0.0125, **p<0.01, ***p<0.001, M±SD, n = 4–6).…”

In vitro analysis of virulence-attenuated Tn mutants. by Joanne Cummins (457912)

“…The mariner mutants in <i>prfB</i> and lmoH7858_0137 have a decreased ability to grow in a high salt environment compared to the wild-type strain. …”

Comparison of MDA levels of hippocampal between different groups. by Hamideh Asadi nejad (18563628)

“…<p>Treatment with a high dose (5mg/kg) but not a low dose (0.5mg/kg) of lutein decreased the MDA level in 2-vessel occluded (2VO) rats. …”

Analysis of the Phospholipid Profile of Metaphase II Mouse Oocytes Undergoing Vitrification by Jaehun Jung (600064)

“…The intensities of phosphatidylinositol (PI) {18∶2/16∶0} [M−H]− and phosphatidylglycerol (PG) {14∶0/18∶2} [M−H]− were decreased the most with fold changes of 30.5 and 19.1 in negative ion mode, respectively. …”

Effects of silencing BRCA1 in MCF-7 cells on Smad3 and Smad4. by Huchun Li (370357)

“…<p>(A) si-BRCA1 decreases Smad3-Smad4-mediated transcriptional activation of p3TP-Lux reporter in MCF7 cells. …”

Graph to show numbers of cells observed on the articular cartilage surface by Frances MD Henson (78253)

“…At day 11 and day 20 there was a significant decrease in the number of cells on the cartilage surface in the samples cultured in the presence of 100 ng/ml BMP-2 (*) compared to both control and SIL sections.…”

Outcomes of curtailing fishing for penguins by SSMU. by Emily S. Klein (4811307)

“…Points below the dashed 1:1 line indicate a decrease in depletion risk owing to a cessation in fishing. …”

Treatment of xenograft tumors by chemotherapy. by Wolfgang Jäger (394799)

“…<p>A. Mice bearing UM-UC13 luc tumors showed a remarkable decrease in tumor volume after systemic therapy with a combination of gemcitabine and cisplatin starting on day #28 after inoculation, compared to PBS control (** = P<0.01). …”

Temporal changes of TH levels in the striatum of PD-induced rats. by Gabriela P. Chaves-Kirsten (468145)

“…<p>TH levels in striatum of rats submitted to unilateral intrastriatal injections of 6-OHDA after 1, 5, 10, 20, and 60 days post-lesion (DPL). (A) Digital images of coronal sections of the dorsolateral striatum shows a decrease in the expression of TH on the 6-OHDA side, with a peak in 10 DPL (B) Digital images of coronal sections of the dorsolateral striatum at 60 DPL; the arrow indicates the site of infusion. …”

Perceived effort for motor control and decision-making - Fig 1 by Ignasi Cos (838096)

“…<p><b>(A)</b> Utility function traces (solid traces) resulting from trading off benefits (black solid trace) minus their associated costs (dashed-dot traces) as a function of movement time (T) for reaching movements of path distance (D) between 5 and 25 cm. …”

Development of lymphangioma in PAI-1 WT or PAI-1^−/− mice. by Françoise Bruyère (4734)

“…<p>A macroscopic decrease of lymphangioma is observed in PAI-1^−/− as compared to WT (A). …”

ATP and phosphocreatine in FVB and Mb hearts after TAC or sham surgery. by Jianxun Wang (290485)

“…TAC decreased the content of ATP (A) and PCr (B), however, the differences between FVB and Mb were not significant. …”

Graph to show numbers of cells captured in 3D gelatin scaffold ('Gelfoam') by Frances MD Henson (78253)

“…At day 11 and day 20 there were significantly reduced numbers of chondrocytes in the Gelfoam in the samples cultured in the presence of 100 ng/ml BMP-2 (*). At day 20 there was a significant decrease in cell numbers in all three experimental conditions.…”

Graph to show numbers of cells extruding out of the articular cartilage surface by Frances MD Henson (78253)

“…At day 11 there was a significant decrease in the number of cells extruding from the cartilage surface in the samples cultured in the presence of 100 ng/ml BMP-2 (*) compared to both control and SIL sections.…”

Transmission and perception of substrate-borne vibrations along <i>Aechmea magdalenae</i>, the roost plant of the katydid <i>D. gigliotosi</i>. by Heiner Römer (52699)

“…<p>When one leaf of the plant is stimulated with a sinusoidal stimulus at 10 Hz (at the position indicated by the large arrowhead), the induced vibrations of the plant differ substantially close to the source (distance 5 cm) and at a distance of 150 cm. …”