Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Compound <b>4f</b> exhibited potent EGFR inhibitory activity with an IC₅₀ value of 61 nM compared to that of Tamoxifen (IC₅₀ value of 69 nM), with EGFR inhibition of 83 and 84%, respectively, at a concentration of 10 μM. Interestingly, <b>4f</b> showed remarkable PI3K/AKT/mTOR inhibitory activity with 0.18-, 0.27-, and 0.39-fold decrease in their concentration (reduction in controls from 6.64, 45.39, and 86.39 ng/mL to 1.24, 12.35, and 34.36 ng/mL, respectively). …”

Time concordance metrics for all TFs, pathways as well as genes using both a minimal |logFC| of 0.5 and 1. by Anika Liu (8411805)

vFLIP maintains intestinal barrier integrity in a short term model <i>in vivo</i>. by Barbara Ruder (8379354)

Gene specific primers used for <i>GmNN1/FT2a</i> fine mapping. by Xinxin Li (281237)

LuxR G37V has decreased DNA-binding activity. by Chelsea A. Simpson (9579303)

European eel, <i>Anguilla anguilla</i> embryos from each treatment were reared in upwelling, 2 L incubators (n = 3) connected to a recirculating aquaculture system (RAS). by Daniela E. Sganga (12427071)

Subjects:

Supplemental Table 2 Phosphokinase Array from Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocar... by Brittany L. Allen-Petersen (14935217)

AgLDL induce the decrease of ΔΨm and ATP in THP-1 macrophages, without mtROS or apoptosis. by Gabriela M. Sanda (10031559)

Proinflammatory signaling pathways were decreased in Ad26.COV2.S vaccinated compared to sham unvaccinated hamsters. by Malika Aid (7303874)

“…<p><b>(A)</b> Boxplots of SARS-CoV-2 transcripts normalized read counts across all animals, vaccinated hamsters are shown in blue and pink, and sham animals in green. …”

Targeted quantitation in aging worms and in an azyx-1a deletion mutant reveals age-dependent zyx-1 fold change and <i>cis</i> regulation by azyx-1. by Bhavesh S. Parmar (11603824)

“…(<b>A</b>) Fold change at day 1 (black) and day 8 (gray) of adulthood in comparison to L4 larval stage for all quantified peptides of AZYX-1 (7 peptides) and ZYX-1 (6 peptides) combined. …”

The I827K substitution destabilizes the 3D fold of E6AP^C-lobe (residues 761–875). by Steven A. Beasley (9099461)

“…<p>(A) The assigned ¹H-¹⁵N-HSQC spectrum of 3.5 mM human E6AP catalytic C-lobe (residues 761–875) using the one-letter amino acid code and residue number according to the human E6AP sequence. …”

Illustrations of the SeqFold2D network and the Stralign dataset. by Xiangyun Qiu (316117)

Relative Aggrecan mRNA expression levels, as measured by qPCR, in lentiviral-transduced control cells and 5 AggKD cell lines confirm decreased Aggrecan expression in the AggKD cell... by Juanita K. Hodax (6848540)

The deletion of the <i>pflB</i> gene led to decreased invasion efficiency in the Caco-2 cell line, which corresponded to a reduced organ burden in C57BL/6 mice five days after infection through oral gavaging. by Debapriya Mukherjee (9961289)

Decrease in vRNA in brain during antiretroviral therapy. by Sonny R. Elizaldi (9684796)

The decreasing rates of V_p with temperature. by Nazlı Tunar Özcan (14833635)

“…In this study, P-wave velocity (V_p), Brazilian tensile strength (σ_t), uniaxial compression strength (σ_c) of Çankırı rock salt were investigated under different temperatures ranging from 20°C to 250°C since the temperature is a factor that causes changes in some physical and geo-mechanical properties of rocks. …”

Phenotype and molecular identification of <i>GmNN1/FT2a</i> in stable transgenic soybean plants. by Xinxin Li (281237)

Video_5_Analog Models of Fold-and-Thrust Wedges in Progressive Arcs: A Comparison With the Gibraltar Arc External Wedge.MP4 by Alejandro Jiménez-Bonilla (8639379)

“…We present laboratory models of fold-and-thrust belts formed with a backstop that deforms in map view to simulate progressive arcs in a thin-skinned tectonic regime. …”

Inhibition of PKC or Rho protein kinase decreases Ad5 wild type replication <i>in vitro</i>. by Alice Liu (4814415)

DnaK inhibits protein synthesis in vivo and in vitro. by Carissa Chan (18310140)