Lestaurtinib Inhibition of the JAK/STAT Signaling Pathway in Hodgkin Lymphoma Inhibits Proliferation and Induces Apoptosis by Tania Diaz (212468)

“…In addition, we have analyzed the effect of Lestaurtinib treatment in lymph nodes from four classic HL patients. We observed a decrease in cell viability at 24 hours of treatment in three patients (mean decrease of 27% at 300 nM). …”

Effect of stimulus discontinuity in the model. by Vinay Shirhatti (12872281)

“…White lines indicate the sublinear E and superlinear I response regime where increase in <i>iI</i> causes gamma amplitude to increase and frequency to decrease (this regime is absent in case 3). Oscillations weaken drastically in the network from case 1 to 2 and 3, even when the mean E and I responses do not change as much. …”

New Targets for Drug Discovery against Malaria by Guido Santos (171018)

“…The potential targets include: 1) increasing the death rate of the gametocytes, 2) decreasing the invasion rate of the red blood cells by the merozoites, 3) increasing the transformation of merozoites into gametocytes, 4) decreasing the activation of the immune system by the gametocytes, and finally 5) a combination of the previous target with decreasing the recycling rate of the red blood cells. …”

Reduction of trained cFL models. by Melody K. Morris (115320)

“…Thus, a selection threshold of 5×10⁻⁴ to 7.6×10⁻³ results in the models at the “filter points” noted in (a).…”

Effect of antidepressants on tegu sleep. by Paul-Antoine Libourel (561599)

“…S1 was scored automatically based on the decrease of the eye movement density associated with a low muscle tone, and S2 scored based on the 15-Hz oscillations. …”

Death-related down-regulated expression changes in WR99210-treated parasites. by Karthikeyan Ganesan (269200)

“…Twenty one genes showed a drug-dependent decrease in gene expression (see <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1000214#ppat.1000214.s009" target="_blank">Table S5</a> for PlasmoDB gene number).…”

Vaccine induced protection against leukopenia. by Simon P. Graham (59745)

“…<p>Leucokyte numbers remained at pre-vaccination levels throughout the experiment in animals vaccinated five days prior to challenge with A) UK2000/7.1 or B) CBR/93 (filled circles), whereas a significant (P<0.05) decrease occurred rapidly after challenge in unvaccinated animals (open circles) and animals vaccinated one day before challenge that developed clinical signs and were euthanized prior to the end of the experiment (open triangles). …”

Longitudinal evaluation of cell viability by <i>in vivo</i> BLI. by Annette Tennstaedt (834294)

“…(B) SBR (signal to background ratio) normalized to the first time point shows a decrease of cell viability within one week. (+) outliers at least 3x interquartile range.…”

The effect of rottlerin on MACC1 expression. by Manisha Juneja (4059493)

“…<p>(A–B) HCT116 cells were treated with increasing concentrations of rottlerin for 24 h (A) or a single dose of 2.5 μM rottlerin (B) for the time points indicated. …”

Mapping of serum neutralizing activity in high titer, protected RM using BG505 Env PV mutants. by Tysheena P. Charles (3385586)

“…The gray infectivity curves represent mutant PVs that did not reach the pre-defined threshold of a 0.5log10 fold increase or decrease in ID₅₀ compared to the parental BG505 Env. …”

Supplementary Material for: Tofacitinib as Induction and Maintenance Therapy in Japanese Patients with Active Ulcerative Colitis by Suzuki Y. (3596711)

“…In OCTAVE Sustain (NCT01458574), 39 patients with clinical response in OCTAVE Induction 1 were re-randomized to placebo, tofacitinib 5 mg, or 10 mg b.i.d. Efficacy endpoints included: remission (primary endpoint; total Mayo score ≤2; no individual subscore >1; rectal bleeding subscore 0); mucosal healing (Mayo endoscopic subscore ≤1); clinical response (≥30% and ≥3-point decrease from induction study baseline total Mayo score; decrease in rectal bleeding subscore ≥1 or absolute subscore ≤1). …”

Image_2_Chromosomal Aberrations in Blood Lymphocytes as Predictors of Respiratory Function After Stereotactic Lung Irradiation.tif by Zsuzsa S. Kocsis (8422800)

“…We also found connections between the in vitro and in vivo CA values (i.e., dicentrics plus rings after 3 Gy irradiation predicts dicentric-plus-ring value directly after the radiotherapy/V_54 Gy (p = 0.001 24.2%)).</p><p>We found that—after further validation—chromosome aberrations resulted from in vitro irradiation before radiotherapy can be a predictive marker of pulmonary function decrease after lung irradiation.…”

Image_1_Chromosomal Aberrations in Blood Lymphocytes as Predictors of Respiratory Function After Stereotactic Lung Irradiation.tif by Zsuzsa S. Kocsis (8422800)

“…We also found connections between the in vitro and in vivo CA values (i.e., dicentrics plus rings after 3 Gy irradiation predicts dicentric-plus-ring value directly after the radiotherapy/V_54 Gy (p = 0.001 24.2%)).</p><p>We found that—after further validation—chromosome aberrations resulted from in vitro irradiation before radiotherapy can be a predictive marker of pulmonary function decrease after lung irradiation.…”

Supplementary Material for: Cardiac Characteristics of the First Two Waves of COVID-19 in Denmark and the Prognostic Value of Echocardiography: The ECHOVID-19 Study by Christensen J. (14201357)

“…Methods: A total of 305 patients hospitalised with COVID-19 were prospectively included, 215 and 90 during the first and second wave, respectively. …”

DataSheet_1_Chromosomal Aberrations in Blood Lymphocytes as Predictors of Respiratory Function After Stereotactic Lung Irradiation.zip by Zsuzsa S. Kocsis (8422800)

“…We also found connections between the in vitro and in vivo CA values (i.e., dicentrics plus rings after 3 Gy irradiation predicts dicentric-plus-ring value directly after the radiotherapy/V_54 Gy (p = 0.001 24.2%)).</p><p>We found that—after further validation—chromosome aberrations resulted from in vitro irradiation before radiotherapy can be a predictive marker of pulmonary function decrease after lung irradiation.…”

Structural understanding versus numerical analysis of Turing patterns, by Selim Haj Ali (21222613)

“…(d), (e) and (f) represent the dispersion relation for a Gierer-Meinhardt model [<a href="https://journals.plos.org/complexsystems//article/info:doi/10.1371/journal.pcsy.0000044#pcsy.0000044.ref026" target="_blank">26</a>] with reaction parameters <i>a</i>₅ = 0.27 and <i>b</i>₅ = 1.57 and diffusion parameters and , zoomed into the three eigenmodes <i>S</i>, <i>M</i> and <i>U</i> around the Turing instability regime. …”

Temporal changes in mitochondrial density and structure in response to Myc. by J. Anthony Graves (164485)

“…<p>(<b>a</b>) <i>Mitochondrial Mass</i>. MycER cells were exposed to 4-HT for up to 35 d at which point 4-HT was removed. …”

Change in perceived lag in monkeys and humans over time. by Manivannan Subramaniyan (391693)

“…Error bars: 95% bootstrap percentile-based plug-in estimates of confidence intervals.(B) Each data point represents a single session for monkey B and up to three consecutive non-overlapping sessions for monkey H (sessions were pooled if necessary, to meet a criterion of a minimum of five trials per stimulus condition). …”

DataSheet_1_Healthcare resource utilization patterns in psoriasis patients using biologic and conventional treatments in Finland.pdf by Aino Vesikansa (18792124)

“…</p>Results<p>The results indicated a remarkable decrease in contacts with a dermatologist after the treatment initiation among patients starting biologic (mean annual number of contacts 5.4 per person before and 2.3 after the initiation), but not conventional (3.3 and 3.2) treatment. …”

OCM impairment is involved in ethanol impact on DNA repair in the PFC. by Anna-Kate Fowler (625791)

“…(B) DNA repair activity in the PFC of WT and <i>Mthfr+/−</i> mice exposed to acute and chronic ethanol. Values are means ± SEM; *p<0.01; **p<0.005; ***p<0.002. Note a decrease in DNA repair activity in the PFC following 3-week (3 w) and even more so following 5 week (5 w) exposure, compared with acute alcohol exposure and a significant exaggeration of this decrease by MTHFR deficiency.…”