Gap detection of the pre-pulse induced inhibition of the acoustic startle response (ASR) for Control (N = 6), Tinnitus(+) (N = 14), and Tinnitus(-) (N = 8) mice at baseline, and 1,... by Laetitia Mwilambwe-Tshilobo (793415)

“…Instead, Tinnitus(-) mice demonstrated gap detection deficits for BBN at 4 and 8 weeks post-exposure, and improved detection in the 6–8 kHz band at 8 weeks post-exposure. Each data point represents population mean ± SEM. *: p<0.05; **: p<.01.…”

Optogenetic suppression of M1/M2 axon terminals in POm. by Jia Qi (400499)

“…Top orange line indicates optogenetic stimulation. The data in S5C-S5E Fig can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3001896#pbio.3001896.s008" target="_blank">S1 Data</a>.…”

Scleral morphological changes in P84 APC^min mice and age-matched normal WT littermates. by Zhen Liu (74646)

“…All mRNA levels are normalized to the control level of WT in P84 (mean ± SD, n = 5, *<i>P</i> < 0.05, **<i>P</i> < 0.01).…”

Effect of PEG-8000 on EGFR, cyclin D1 and p21 expression in SCC-25 cells-For these studies, western blot analysis was performed on lysates obtained from SCC-25 cell treated for 24... by Ramesh K. Wali (305603)

“…<p>As shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0038047#pone-0038047-g005" target="_blank">Figure 5A</a>, consonant with the <i>in vivo</i> experiments PEG caused a significant decrease EGFR (∼45% compared to vehicle control; p<002) and cyclin D1 (∼57% compared to control vehicle; p<0.005) expression. …”

Transducer mechanisms activated by D1-like receptors. by Catalina Valdés-Baizabal (701863)

“…The use of H89 in the intracellular solution decreased the inhibitory effect of A-68930 from 29 ± 4% to 16 ± 5% at −10 mV (<i>P</i> = 0.08). …”

Evolutionary Consequences of Altered Atmospheric Oxygen in <em>Drosophila melanogaster</em> by Marc Charette (198776)

“…<div><p>Twelve replicate populations of <em>Drosophila melanogaster</em>, all derived from a common ancestor, were independently evolved for 34+ generations in one of three treatment environments of varying PO₂: hypoxia (5.0–10.1 kPa), normoxia (21.3 kPa), and hyperoxia (40.5 kPa). …”

Treatment of landfill leachate using Fenton Processes and Photo-Fenton Solar by Fábio Moraes da Costa (5376350)

“…These conditions led to a decrease in the toxicity of leachates' coefficient values to a degree equal to 50 % - for Aliivibrio fischeri greater than 50% - indicating a more suitable leachate for further biological treatment.…”

<i>Def6</i> RNA rescues the <i>def6</i> MO-induced phenotype. by Katerina Goudevenou (199855)

“…ANOVA single factor and two-tailed Student's <i>t</i>-tests showed a significant (p<0.001; three asterisks) increase in the angle after injection of 2.5 ng <i>def6</i> MO and a significant (p<0.001; three asterisks) decrease in the angle after addition of <i>def6</i> RNA. …”

Effect of ASM-024 on lung tissue resistance in response to methacholine. by Evelyne Israël Assayag (512451)

“…A single 5 minutes exposure to 1.5 mg/kg nebulized ASM-024 prior to the methacholine challenge significantly decreased airway resistance in OVA-sensitized mice; p<0.05 for 0.06, 0.125, 0.25 and 1 mg/kg methacholine (A). …”

Our motoneuron model demonstrates that synaptic input noise does not account for signal dependent noise in synaptic input. by Akira Nagamori (4743981)

“…Note that this relationship is expressed as <i>SD</i> ∝ <i>mean</i>^0.5. B) Motoneuron discharge rates as a function of synaptic currents with (blue line) and without hysteresis (orange line) in motoneuron discharges. …”

The F2-isoprostane approach allows for analysis of FOXO transcription factor control of endogenous oxidative stress. by Christiaan F. Labuschagne (485155)

“…DLD-1 and DL-23 cells were incubated with 4-OHT to activate FOXO3a for 24 hours, before treatment with PQ for another 8 hours. 5-iPF2α-VI levels were analyzed and data are represented as mean fold increase ± S.E.M (*p < 0.05, *** p < 0.001).…”

Effect of antenatal class attendance on fear of childbirth and antenatal stress by Selda Yörük (15298001)

“…Fear of childbirth score were not significantly different between the intervention group and the control group. The mean APSI score of pregnant women in the intervention group was 22.32 ± 6.12 before the training and 21.79 ± 5.97 after the training. …”

Activation of the UPR can override the inhibition of NF-κB by IKK inhibitors in cancer cells with elevated IKK activity. by Arvin B. Tam (124164)

“…A reduction in P-IκBα and increase in total IκBα were seen corresponding to a decrease in IKK activity. …”

Reconsolidation and extinction after different strengths of training. by Remus Osan (3639754)

“…Bars indicate freezing in vehicle (dark blue) and anisomycin (light blue) groups before (left set) and after (right set) reexposure with <i>t</i> = 4 (mean ± S.E.M. of 100 simulations). As occurs in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023113#pone-0023113-g003" target="_blank">Figure 3C</a>, freezing is decreased by anisomycin administration, indicating reconsolidation blockade. …”

Expression of miR-202-3p and its target Sufu mRNA in CLL cells. by Mosavar Farahani (819379)

“…<p><b>(A)</b> HS-5 cells incubated with MEC-1 exosomes for 24 hrs show increased expression of miR-202-3p by RT-qPCR analysis. …”

Automated gait analysis reveals early signs of motor defects in <i>Mecp2^stop/y</i> mice. by Kamal K. E. Gadalla (659748)

“…<i>Mecp2^stop/y</i> mice show a gradual phenotype score progression that is significantly different from WT (WT n = 7; <i>Mecp2^stop/y</i> n = 8 at 3–7 weeks, n = 7 at week 8, n = 5 at week 9 and n = 4 at week 10); decreasing numbers of <i>Mecp2^stop/y</i> mice are explained by early death of some mutant mice. …”

Pre-seeded scaffolds promote more effective tissue regeneration. by Paul P. Bonvallet (708039)

“…*Represents p<0.01 for all treatment groups that are significantly different from each other within the same time point. Also, all treatment groups significantly decreased over time (p<0.001).…”

The effect of dopamine on Δψ_m and [Ca²⁺]_c in midbrain neurons and astrocytes. by Sonia Gandhi (49260)

“…Figure bi demonstrates the increase in Rh123 fluorescence at 1 minute, 6 minutes and 12 minutes that reflects mitochondrial membrane depolarisation in PINK1 ko cells. c, d: Single cell traces of PINK1 ko neurons demonstrating that dopamine induced decrease in ΔΨ_m occurs independently of any change in [Ca²⁺]_c in some cells (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037564#pone-0037564-g001" target="_blank">Figure 1c</a>), whereas in other cells dopamine induced decrease in ΔΨ_m co-incides with a rise in [Ca²⁺]_c (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037564#pone-0037564-g001" target="_blank">Figure 1d</a>). e: Incubation with D1/D5 receptor antagonist SCH23390 (20 µM) did not alter the dopamine induced calcium signal or mitochondrial depolarisation in PINK1 ko neurons. f: Dopamine induced mitochondrial depolarisation was prevented by application of the PTP inhibitor 1 µM cyclosporine A.…”

Elimination testing with adapted scoring reduces guessing and anxiety in multiple-choice assessments, but does not increase grade average in comparison with negative marking by Jef Vanderoost (5108072)

“…The comparison is structured around seven hypotheses: in comparison with negative marking, elimination testing with adapted scoring leads to (1) a similar average score (no grade inflation); (2) students expressing their partial knowledge; (3) a decrease in the number of blank answers; (4) no gender bias in the number of blank answers; (5) a reduction in guessing; (6) a decrease in self-reported test anxiety; and finally (7) students preferring elimination testing with adapted scoring over negative marking.…”

Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stability-0 by Andreas Peth (85734)

“…Whereas the anti-CSN5 antibody revealed a reduction to 23% as compared to the control, there was no decrease of the CSN complex observed with the anti-CSN8 antibody. …”