Figure 2 by Kazuo Konishi (195884)

“…<p>A) DNA methylation status of thirteen cancer-specific or age-related genes/CpG islands in 16 primary CRCs and matched liver metastasis. …”

Results of MC simulations of VO and agonist infusion. by Johane H. Bracamonte (12883844)

“…<p>Top panels show normalized growth in CellArea for 100 representative simulations (gray lines), with terminal values indicated by black circles; adjacent boxplots reflect the mean, CI50, and CI90 of terminal values for 1000 simulations of a) Untreated VO, c) ISO infusion, and e) AngII infusion. …”

Treatment of gp130^757FF mice with WP1066 reduces tumour size. by Louise M. Judd (185660)

“…Antral tumours in 8 week untreated mice (A) and 10 week DMSO-treated vehicle controls (B) were no different in mean area, however WP1066 treatment resulted in ∼50% smaller tumours (C). …”

Co-expression of PGRN rescues the axonopathy induced by Mt TDP-43 but not Mt SOD1. by Angela S. Laird (360986)

“…<p>A) Staining of primary motor axons with an anti-synaptic vesicle 2 revealed a decrease in axonal length and increase in aberrant branching in embryos expressing Mt TDP-43 compared with Wt TDP-43. …”

Increase of intrinsic apoptosis in irradiated HNSCC cancer stem cells. by Anthony Boivin (298008)

“…<p>After cell sorting, two sub-populations were obtained from the SQ20B carcinoma cell line: CD44⁺ cancer stems cells (A, C, E) and a CD44⁻ side population (B, D, F) which were grown in the SQ20B culture medium for 10 days. …”

Characterization of lipid rafts isolated from the nerve trunks and their role in the organization of GIR. by Caroline Fasano (76332)

“…The low density fraction (3) exhibited high cholesterol content and low protein/cholesterol ratio compared to the high density fractions. b, c, Western blot analysis of the gradient fractions showed the enrichment of the fraction 3 in ganglioside GM1 and annexin II. c, d, decrease in annexin II (Western blot) in the rafts fraction isolated from the nerve trunks and depletion of cholesterol by 10 mM MβCD (mean of four assays from one experiment, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0000612#s4" target="_blank">methods</a>). …”

Extension, twist and writhe changes of DNA during nucleosome-wrapping. by Chunhong Long (6858428)

“…(B) The mean extension increment resulting from nucleosome wrapping is a function of supercoil and stretching force. …”

Echocardiographic characteristics by patient group based on initial qualitative RV assessment of “normal”, “mild/mod” and “severe” RV enlargement. by Chad S. Weldy (9628603)

“…<p>(A) RV end diastolic area (cm²) (RVEDA) and (B) RV end systolic area (cm²) (RVESA) increased with mild-moderate and severe RV enlargement, (C) right atrial area (cm²) increased with severe RV enlargement, (D) RV fractional area change (RVFAC) showed a trend toward a decrease with severe RV enlargement, (E) RV free wall Lagrangian longitudinal strain (RVLS) showed a trend toward an increase with severe RV enlargement, and (F) LV ejection fraction (LVEF%) was similar in all groups, N = 4-11/group. …”

TSLPR-deficiency and IL-7R blockade alter numbers of thymocytes and splenocytes. by Maarten R. Hillen (760783)

“…Total numbers of splenocytes were decreased in anti-IL-7R treated TSLPR-/- mice compared to PBS treated WT mice (C), associated with a decrease in CD4+ and CD8+ T-cells in the anti-IL-7R treated TSLPR-/- mice (D). …”

Whole-cell [Ca²⁺]_i transients in hiPSC-CMs and their requirement for Ca²⁺ influx via L-type Ca²⁺ channels. by Ilanit Itzhaki (225708)

“…<p>(<b>A</b>) Confocal line-scan images showing changes in intracellular Ca²⁺ in a fluo-4 loaded hiPSC-CM (derived from the hIH1 line). …”

Modeling limb enhancers sequence composition and its integration with chromatin information. by Remo Monti (4379632)

“…(<b>B</b>) Same as (A) but showing AUPRC. (<b>C</b>) Bar plot showing the average coefficient from the LASSO models for those sequence features selected in 9/10 of splits during LASSO training and reported in the top 25% in terms of mean decrease in accuracy, as estimated during RF training. …”

Altered Responses to Homeostatic Cytokines in Patients with Idiopathic CD4 Lymphocytopenia by Florence Bugault (278171)

“…The induction of phospho-STAT5 after IL-7 stimulation was decreased in memory CD4⁺ T cells of some ICL patients, which correlated with a decreased expression of the IL-7Rα receptor chain (R = 0.74, p<0.005) and with lower CD4⁺ T cell counts (R = 0.69, p<0.005). …”

An automated quantitative analysis of cell, nucleus and focal adhesion morphology by Antonetta B. C. Buskermolen (5043563)

Image1_Identification of miRNAs related to osteoporosis by high-throughput sequencing.jpeg by Jiachun Huang (19350616)

“…The qRT-PCR results showed that miR-140-5p, miR-127-3p, miR-199b-5p, miR-181a-5p, miR-181d-5p, and miR-542-3p exhibited a decrease of 2.27-, 3.00-, 3.48-, 2.67-, 2.41-, and 1.98-fold (all P < 0.05) in osteoporosis compared to controls. …”

Synaptic potentiation reduces AP onset, threshold and AHPs. by Sung-Cherl Jung (261358)

“…Examples of APs traces recorded before (black) and 30 min (red) after conditioning stimulation are given for paired and unpaired conditions. Scale bars: 40 mV, 200 ms. (right panel) Pooled data. The threshold to fire the first AP was lowered initially after LTP induction and this decrease persisted throughout the recording episode. …”

Assessments of the Inhibitory Effects of YC-1 on hRMVECs. by Michael DeNiro (297385)

“…The effects of addition of VEGF, DMSO, SN50M, SN50, and YC-1 on EC lumen formation over the time course of 24 hours, with the bar graph highlighting EC lumens per high power field [HPF] at 24 hour time point. SN50 and YC-1 treatments significantly [***P<0.001] decreased the number of lumen formed in hRMVECs as compared to their respective controls, SN50M and DMSO, respectively. …”

Introduction of FOXA1 into AB32 cells alters progestin response. by Christine L. Clarke (169388)

“…Red - increased log fold expression, green - decreased log fold expression. (B) FOXA1 protein expression in AB32 cells and parent MCF-10A cells before and after viral transduction, compared with endogenous expression in T-47D cells. …”

HMGB1 induces Src activation. by Mengchen Zou (725646)

“…EA.hy926 cells were plated in the upper part of transwell chambers until the formation of a tight monolayer. The cells were preincubated with 1, 2.5, 5, 10 or 20μM PP2 (upper) or 0.5, 1, 2.5, 5 or 10 μM CGP77675 (lower) for 1 h, respectively. …”

Immune Profiles to Predict Response to Desensitization Therapy in Highly HLA-Sensitized Kidney Transplant Candidates by Julie M. Yabu (3174753)

“…Responders to desensitization therapy were defined as 5% or greater decrease in cumulative calculated panel reactive antibody (cPRA) levels, and non-responders had 0% decrease in cPRA. …”

Dopamine Neurons Change the Type of Excitability in Response to Stimuli by Ekaterina O. Morozova (3386927)

“…Furthermore, we analyzed how excitability type of the DA neuron model is influenced by changes in the intrinsic current composition. A subthreshold sodium current is necessary for a continuous frequency decrease during application of a negative current, and the low-frequency “balanced” state during simultaneous activation of NMDA and GABA receptors. …”