Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…The triazolo­[1,5-<i>a</i>]­pyrimidine may be a promising scaffold for developing more potent ABCB1 modulators.…”

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…The triazolo­[1,5-<i>a</i>]­pyrimidine may be a promising scaffold for developing more potent ABCB1 modulators.…”

Datasheet1_MiR-125a-5p regulates the radiosensitivity of laryngeal squamous cell carcinoma via HK2 targeting through the DDR pathway.pdf by Qiwei Wang (246825)

“…Additionally, HK2 exhibited high expression in LSCC and the biological function was opposite to miR-125a-5p. Western blotting analysis revealed that miR-125a-5p increased rH2AX levels and decreased H2AX levels, conversely, HK2 had the opposite effect on miR-125a-5p. …”

Blood concentrations of VEGF-A121, VEGF-A165, and VEGF-A pre- and post-bevacizumab administration. by Masashi Okawa (8951294)

Image_5_CircFAM114A2 Promotes Cisplatin Sensitivity via miR-222-3p/P27 and miR-146a-5p/P21 Cascades in Urothelial Carcinoma.png by Jiancheng Lv (464636)

“…</p>Conclusion<p>CircFAM114A2 could inhibit progression and promote cisplatin sensitivity in urothelial carcinoma through novel circFAM114A2/miR-222-3p/P27 and circFAM114A2/miR-146a-5p/P21 pathways. …”

Principal Coordinate Analysis (PCoA) based on (A) Unweighted UniFrac, (B) Weighted UniFrac, (C) Bray-Curtis dissimilarity, and (D) Jaccard similarity. by Manal Ali Ahmad (16868808)

Measuring instrument (a) Armored thermal resistance for high voltage and waterproof ground (b) Thermal resistance of measuring the inlet and outlet water temperature (c) Turbine fl... by Rui Zhang (13940)

The top 100 TCs with highest excess deaths from all-cause, CVDs, and RDs. by Wenzhong Huang (538470)

Zaprinast reduces eEPSC amplitude at CA3→CA1 synapse in a PDE5-and cGMP-indipendent manner. by Rolando Berlinguer-Palmini (491113)

“…<p><b>A</b> and <b>C</b>) Time course of the zaprinast-induced decrease in eEPSC amplitude alone (<i>A</i>) and in the presence of Rp-8-Br (a cGMP-dependent protein kinase-PKG- inhibitor). …”

Catalytic Four-Electron Reduction of Oxygen to Water by a Molecular Cobalt Complex Consisting of a Proton Exchanging Site at the Secondary Coordination Sphere by Avijit Das (4491220)

“…The overpotential (η) of H₂O formation (ca. 0.8–0.65 V) decreased proportionally with increasing pH in PBS and ABS. …”

Catalytic Four-Electron Reduction of Oxygen to Water by a Molecular Cobalt Complex Consisting of a Proton Exchanging Site at the Secondary Coordination Sphere by Avijit Das (4491220)

“…The overpotential (η) of H₂O formation (ca. 0.8–0.65 V) decreased proportionally with increasing pH in PBS and ABS. …”

Intrinsic Functional Connectivity Alterations of the Primary Visual Cortex in Primary Angle-Closure Glaucoma Patients before and after Surgery: A Resting-State fMRI Study by Shenghong Li (3697315)

“…</p><p>Conclusions</p><p>The primary findings have demonstrated a gradual decrease in visual information integration in the left V1-V2 pathway and VA-related functional compensation in the pre-PACG patients, generating further evidence of functional restoration in post-PACG patients.…”

Serum concentrations of FGF23 at baseline and at week 40 in patients that achieved a serum phosphate concentration of <4.5 mg/dL and >4.5 mg/dL). by Cristian Rodelo-Haad (5607911)

“…Bars represent median and interquartile range. Serum iFGF23 decreased from 581.0 pg/mL (491.2–886.0) to 238.5 pg/mL (116.7–443.5) [median percent change of 63.8% (-75.2–5.40) in patients that achieved the target of phosphate <4.5 mg/dL. …”

Nanobody 19 stabilizes PRL-3 structure at two sites and destabilizes PRL-3 at one interaction point. by Caroline N. Smith (15852909)

EFFECT OF STEEL PLATE THICKNESSES AND FLUID FLOW CHARACTERISTICS OF AN IMPINGING AIR JET ON HEAT TRANSFER AT THE STAGNATION POINT by K. Jeyajothi (7032425)

“…The effect of thickness of a steel plate on heat transfer characteristics with an impinging air jet at the stagnation point was studied. …”

Nanobody 26 stabilizes PRL-3 structure at two sites and destabilizes PRL-3 at one interaction point. by Caroline N. Smith (15852909)

Efficacy of mouthrinses in reducing oral SARS-COV-2 load: a review by Claudio Mendes PANNUTI (5790461)

“…However, the majority of these trials failed to demonstrate a significant inter-group difference between active groups and the control group relative to the decrease in salivary SARS-CoV-2 loads. …”

DataSheet_1_Decreased Survival of Invasive Ductal Breast Cancer Patients With Two Macrometastatic Lymph Nodes Among Few Resected Ones: Should Current Sentinel-Lymph-Node Guidelines... by Felipe A. C. Luz (11153445)

“…The positive-to-analyzed LN proportion demonstrated a strong prognostic factor for a low rate (1 positive to ≤1.5 analyzed) [HR = 1.567 (1.156–2.126), p = 0.004], and analysis derived from the results demonstrated that a “negative LN margin” improves survival. …”

DataSheet_1_Decreased Survival of Invasive Ductal Breast Cancer Patients With Two Macrometastatic Lymph Nodes Among Few Resected Ones: Should Current Sentinel-Lymph-Node Guidelines... by Felipe A. C. Luz (11153445)

“…The positive-to-analyzed LN proportion demonstrated a strong prognostic factor for a low rate (1 positive to ≤1.5 analyzed) [HR = 1.567 (1.156–2.126), p = 0.004], and analysis derived from the results demonstrated that a “negative LN margin” improves survival. …”

RMSD graphs for the backbone of WT PARG1, I845V and T622M mutants. by Zen Kouchi (14898435)