Gradual increase in the extent of γ-secretase saturation with its substrate leads to gradual changes from the biphasic to the standard dose-response curves. by Željko M. Svedružić (105215)

“…Further increase in the substrate (i.e. cDNAwtC99 >250 ng/mL) leads to decrease in Aβ 1–40 secretion (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050759#pone-0050759-t002" target="_blank">Table 2B</a>), which indicates that the substrate can also bind to the inhibition site (i.e. antagonism between complex <b><u>5</u></b> and complex <b><u>6</u></b>).…”

Loss of OPCs starts during the first postnatal week in the corpus callosum after genetic ablation of <i>C1ql1</i>-expressing OPCs. by Shayan Moghimyfiroozabad (19066182)

“…Data are represented as mean ± SEM. <i>C1ql1</i>^<i>wt</i><i>; Sox10</i>^<i>DTA</i>: <i>n</i> = 3–5 animals. …”

External bases do not catalyze some McLOV proteins. by Kaley K. El-Arab (733285)

“…In contrast, a Thr27Ile demonstrates spectra consistent with LOV chemistry (E) with a 100-fold decrease in the rate of adduct decay (F). …”

Involvement of calcium influx and intracellular stores in NH₄⁺/NH₃-induced calcium changes. by Nicole Haack (621328)

“…<p><b>(A)</b> Influence of combined removal of extracellular calcium with the NMDA-receptor blocker DLAP5 (“0Ca²⁺/100 µM DLAP5”; indicated by bar) on NH₄⁺/NH₃-induced calcium changes in a hippocampal astrocyte. …”

Combination of cetuximab and trametinib was more effective in the partially responsive group ex vivo. by Takahiro Tashiro (827031)

“…The drugs for which the relative ATP content was less than 0.5 are indicated. Mean values are shown. N = 4. …”

Lack of PRLR impaired brown adipose tissue development in newborns. by Say Viengchareun (39121)

“…Adipocyte cell surface was calculated using the Lucia software and a significant decreased was detected in PRLR KO mice (n = 5) <i>vs</i> controls (n = 5) (***p<0.001, n = 200 cells /group). …”

NMDA does not alter PPR but does potentiate postsynaptic responses to glycine. by Michelle L. Kloc (7359230)

“…<p>A. Paired pulse ratio does not decrease after NMDA-induced potentiation. …”

<i>In vitro</i> differentiation of <i>Mecp2</i> wild type ES cells is accompanied by large scale heterochromatin reorganization. by Bianca Bertulat (126768)

“…We noticed a highly significant (p<0.0001) decrease of mean chromocenter number per nucleus within the first two weeks of differentiation. …”

Image_1_Post-eastern Mediterranean Transient Oxygen Decline in the Deep Waters of the Southeast Mediterranean Sea Supports Weakening of Ventilation Rates.jpeg by Guy Sisma-Ventura (6504992)

“…<p>Long-term trends in oxygen, salinity, and nutrients were followed in the Southeastern Mediterranean (SEMS) deep waters from 2002 to 2020. Results show a net decrease in oxygen since 2008 of −0.5 ± 0.1 μmol kg⁻¹ yr⁻¹ in the bathypelagic depths (1,200–2,000 m). …”

Effect of breathing hypoxic gas on vascular oxygenation of 4T1 and 4T07 tumors. by Narasimhan Rajaram (474255)

“…</b> 24 hours after breathing hypoxic gas, there was a significant decrease in SO₂ of the 4T1 tumors (n = 4; p = 0.04), which had returned to a mean value close to pre-hypoxia baseline. 1 animal had to be censored before the 24 hours post-hypoxia measurement. …”

Application of bar-code to cell counting studies. by Irina Krylova (585893)

“…Growth measurements are shown as the mean +/− sd from 8 (Fig. 5B) or 16 (Fig. 5D) wells for each treatment condition. *, statistically significant (p<0.01) increases or decrease in cell number relative to vehicle-treated cells; #, statistically significant (p<0.01) increase in cell number of DHT/actinomycin D treated wells relative to actinomycin D-treated wells.…”

Reelin is secreted by GABAergic neurons. by Cecilia Gonzalez Campo (264260)

“…Treatment with BFA did not change the proportion of intense reelin IR neurons: 21.1±1.2% before treatment (n = 8) and 21.0±1.9% after 16 hours (n = 6), whereas it caused a significant decrease in the fraction of punctate reelin IR neurons. …”

Blink-induced error and microsaccade properties. by Francisco M. Costela (647619)

“…<p>(<b>A</b>) Normalized magnitude distributions of blink-induced fixation errors, post-blink microsaccades, and post-blink drifts across non-human primates. …”

Cell Proliferation and Death by Maria Jaramillo (178403)

“…<p>Morphological analysis of the cells after <b>(A)</b> DE induction showing heterogeneous populations under all conditions (Scale bar: 12.5 µM), and <b>(B)</b> Cell death after 24 h of DE treatment. …”

Beclin-1 haploinsufficiency extends lifespan in AR113Q males. by Zhigang Yu (201128)

“…Age of disease onset as measured by a decrease of 5% or more in forelimb grip strength (not significant by log rank analysis).…”

Platelet count 20 hours after CASP surgery. by Julia van der Linde (8786333)

“…<p>Untreated mice had a mean platelet count of 7.1 (1.76 IQR) × 10⁹/ml, white column. …”

NFHp immunolabeling. by Damián Dorfman (293002)

“…In SE-housed animals, experimental diabetes induced a significant decrease in these parameters in the distal (but not proximal) ON which was prevented by EE housing. …”

SB204741 restricts motion of pSRC. by James D. West (849663)

“…Eularian analysis of fluorescently labeled tubulin and SRC in endothelial cells shows elevated motility in vehicle treated mutant cells, as well as a significant decrease in motility in mutants cells treated with SB204741. …”

Ryanodine-sensitive Ca²⁺ stores. by Ilanit Itzhaki (225708)

“…(<b>D</b>) Dose-response curve for the effects of ryanodine (5, 10, 15 and 20 µM) on whole-cell [Ca²⁺]_i transients amplitude displayed as the percentage of decrease from baseline values. …”

Normal learning and extinction in the model. by Remus Osan (3639754)

“…Freezing increases after learning of memory 2 (red bar), but decreases again (blue bar) after extinction learning (corresponding to a single reexposure session with <i>t</i> = 10). …”