Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists by Dilip K. Tosh (1668115)

“…While screening off-target effects of rigid (<i>N</i>)-methanocarba-adenosine 5′-methylamides as A₃ adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). …”

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists by Dilip K. Tosh (1668115)

“…While screening off-target effects of rigid (<i>N</i>)-methanocarba-adenosine 5′-methylamides as A₃ adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). …”

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists by Dilip K. Tosh (1668115)

“…While screening off-target effects of rigid (<i>N</i>)-methanocarba-adenosine 5′-methylamides as A₃ adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). …”

Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists by Dilip K. Tosh (1668115)

“…While screening off-target effects of rigid (<i>N</i>)-methanocarba-adenosine 5′-methylamides as A₃ adenosine receptor (AR) agonists, we discovered μM binding hits at the δ-opioid receptor (DOR) and translocator protein (TSPO). …”

Even a Chronic Mild Hyperglycemia Affects Membrane Fluidity and Lipoperoxidation in Placental Mitochondria in Wistar Rats - Fig 6 by María del Consuelo Figueroa-García (832711)

Polyfunctionality of <i>T</i>. <i>cruzi</i>-specific CD4⁺ T cells in patients with chronic Chagas disease with no sign of cardiomyopathy is improved after <i>in vitro</i... by María Ailén Natale (6843422)

Quisinostat-mediated HDAC inhibition results in a dissociation of the driving complex in synovial sarcoma. by Aimée N. Laporte (3617987)

“…<p>(A, B) Proximity ligation assay of SS18-SSX/TLE1 nuclear signal demonstrates a significant decrease in detectable protein co-localization following HDAC inhibition in SYO-1 synovial sarcoma cells. …”

Data Sheet 1_The “best practices for farming” successfully contributed to decrease the antibiotic resistance gene abundances within dairy farms.docx by Barbara Salerno (12894908)

“…ARGs (bla_TEM, ermB, sul2, and tetA) were initially screened by end-point PCR, followed by quantification using digital droplet PCR. …”

Nanotribological Properties of the h‑BN/Au(111) Interface: A DFT Study by Merve Baksi (7831742)

“…However, the interfaces between these two-dimensional materials and metals red from a tribological point of view, important for such applications as friction force microscopy, have yet to be thoroughly investigated. …”

Effect of induction of HO-1 (CoPP) and inhibition of HO (SnMP) in mice fed a high fructose diet for 8 weeks on hepatic lipogenesis and FFA levels. by Komal Sodhi (540891)

Bald thigh syndrome in sighthounds—Revisiting the cause of a well-known disease by Magdalena A. T. Brunner (4532341)

“…Further research is required to clarify whether the <i>IGFBP5</i> variant represents a predisposing genetic risk factor. …”

Comparison of the time course of the SARS-CoV-2 pandemic up to 7 November 2020 for the seven regions in England for the time-varying IFR model between using death within 28 days of... by Siyu Chen (278663)

Plots of all outcome measures within cortical (upper half) and subcortical (lower half) ROI's per group and time point. by Mirko Pham (93829)

“…This effect of CBF was paralleled by a decrease in cortical and subcortical ADC in controls, but stable cortical ADC in <i>anti-GPIb</i> treated mice and less severe subcortical ADC decrease in <i>anti-GPIb</i> treated mice as compared to controls (second column). …”

Synthesis, Crystal Structure, and Spectroscopic Characterization of a Series of Cubane-like Mo−Sb Clusters Containing a [Mo₃SbOS₃]⁷⁺ Core by Shao-Fang Lu (2974926)

“…Crystal data:  <b>1</b>, triclinic, <i>P</i>-1, <i>a</i> = 11.746(4) Å, <i>b</i> = 12.462(3) Å, <i>c</i> = 17.851(6) Å, α = 73.54(2)°, β = 75.06(3)°, γ = 88.11(3)°, <i>V</i> = 2419(3) ų, <i>Z</i> = 2, 4253 reflections, <i>R</i> = 0.055; <b>2</b>, triclinic, <i>P</i>-1, <i>a</i> = 12.76(1) Å, <i>b</i> = 17.86(1) Å, <i>c</i> = 11.882(4) Å, α = 75.05(4)°, β = 88.15(7)°, γ = 73.24(4)°, <i>V</i> = 2502(6) ų, <i>Z</i> = 2, 1849 reflections, <i>R</i> = 0.086; <b>3</b>, triclinic, <i>P</i>-1, <i>a</i> = 11.727(4) Å, <i>b</i> = 12.951(3) Å, <i>c</i> = 17.957(4) Å, α = 73.52(3)°, β = 76.22(3)°, γ = 89.00(2)°, <i>V</i> = 2536(3) ų, <i>Z</i> = 2, 6306 reflections, <i>R</i> = 0.053; <b>5</b>, triclinic, <i>P</i>-1, <i>a</i> = 13.261(4) Å, <i>b</i> = 13.529(4) Å, <i>c</i> = 12.535(8) Å, α = 101.54(3)°, β = 105.13(4)°, γ = 93.20(2)°, <i>V</i> = 2113(2) ų, <i>Z</i> = 2, 4104 reflections, <i>R</i> = 0.060.…”

Oligodendrocyte Kpna expression alters with differentiation. by Benjamin M. Laitman (825245)

“…<p><b>(A,B)</b> T3 and CNTF both induce differentiation of OL. …”

A 5-year trend in the use of sodium-glucose co-transporter 2 inhibitors and other oral antidiabetic drugs in a Middle Eastern country by Zaghloul, Nancy

Get full text
Get full text

Photographs of the left eye 5 years (A–D) and 8 years (E) after systemic corticosteroid therapy in a patient shown in Fig 2. by Saho Saito (731215)

Distribution of mCSM-PPI2 [13] predicted ΔΔG from in silico saturation mutagenesis of the ACE2-S interface in PDB 6vw1 [11]. by Stuart A. MacGowan (11326845)

S1 File - by Ștefan Andrei Neştian (14755581)

“…In addition, the results show that the number of accidents should decrease due to the fact that disposable gloves and footwear protection are used while performing AGPs on patients with COVID-19 and hand hygiene is practised before and after touching a patient with COVID-19 (regardless of glove wearing).…”

Model summary. by Ștefan Andrei Neştian (14755581)

“…In addition, the results show that the number of accidents should decrease due to the fact that disposable gloves and footwear protection are used while performing AGPs on patients with COVID-19 and hand hygiene is practised before and after touching a patient with COVID-19 (regardless of glove wearing).…”